Fmr LLC

CIK: 0000315066

Transaction Breakdown

Open Market Buys (P)0 (0.0%)

High conviction signal

Open Market Sales (S)34 (53.1%)

Position reduction

Option Exercises (M)0 (0.0%)

Derivative conversions

Awards (A)0 (0.0%)

Compensation grants

Other (G, F, J, C, D, …)30 (46.9%)

Gifts, tax withholding, conversions, dispositions to the issuer and other codes

Companies & Roles (7)

GPCR

Structure Therapeutics Inc.

10% Owner

BEAM

Beam Therapeutics Inc.

10% Owner

AVLN

Avalyn Pharma Inc.

10% Owner

RLYB

Rallybio Corp

10% Owner

MTSR

Metsera, Inc.

10% Owner

SANA

Sana Biotechnology, Inc.

10% Owner

BCAX

Bicara Therapeutics Inc.

Discretionary Trading P&L

Holdings

Transaction History (64 total)

GPCR
Structure Therapeutics Inc.
Jul 22, 2026
Sale(S)
American Depositary Shares
Indirect
1.4K shares at avg. $50.07-
GPCR
Structure Therapeutics Inc.
Jul 22, 2026
Sale(S)
American Depositary Shares
Indirect
16.1K shares at avg. $50.07-
BEAM
Beam Therapeutics Inc.
Jun 26, 2026
Sale(S)
Indirect
251.5K shares at avg. $35.26$8.9M
BEAM
Beam Therapeutics Inc.
Jun 25, 2026
Sale(S)
Indirect
33.4K shares at avg. $35.12$1.2M
AVLN
Avalyn Pharma Inc.
May 1, 2026
Conversion(C)
Indirect
225.8K shares-
AVLN
Avalyn Pharma Inc.
May 1, 2026
Conversion(C)
Indirect
872.9K shares-
AVLN
Avalyn Pharma Inc.
May 1, 2026
Conversion(C)
Indirect
377.9K shares-
AVLN
Avalyn Pharma Inc.
May 1, 2026
Conversion(C)
Indirect
727.6K shares-
AVLN
Avalyn Pharma Inc.
May 1, 2026
Conversion(C)
Indirect
80.3K shares-
GPCR
Structure Therapeutics Inc.
Apr 14, 2026
Sale(S)
American Depositary Shares
Indirect
16.1K shares at avg. $55.07-
GPCR
Structure Therapeutics Inc.
Apr 14, 2026
Sale(S)
American Depositary Shares
Indirect
1.4K shares at avg. $55.07-
GPCR
Structure Therapeutics Inc.
Jan 15, 2026
Sale(S)
American Depositary Shares
Indirect
6.5K shares at avg. $84.22-
GPCR
Structure Therapeutics Inc.
Jan 15, 2026
Sale(S)
American Depositary Shares
Indirect
230 shares at avg. $85.04-
GPCR
Structure Therapeutics Inc.
Jan 15, 2026
Sale(S)
American Depositary Shares
Indirect
330 shares at avg. $83.35-
GPCR
Structure Therapeutics Inc.
Jan 15, 2026
Sale(S)
American Depositary Shares
Indirect
5.5K shares at avg. $82.10-
GPCR
Structure Therapeutics Inc.
Jan 15, 2026
Sale(S)
American Depositary Shares
Indirect
465 shares at avg. $82.10-
GPCR
Structure Therapeutics Inc.
Jan 15, 2026
Sale(S)
American Depositary Shares
Indirect
552 shares at avg. $84.22-
GPCR
Structure Therapeutics Inc.
Jan 15, 2026
Sale(S)
American Depositary Shares
Indirect
20 shares at avg. $85.04-
GPCR
Structure Therapeutics Inc.
Jan 15, 2026
Sale(S)
American Depositary Shares
Indirect
3.9K shares at avg. $83.35-
GPCR
Structure Therapeutics Inc.
Dec 8, 2025
Sale(S)
American Depositary Shares
Indirect
709 shares at avg. $92.52-
GPCR
Structure Therapeutics Inc.
Dec 8, 2025
Sale(S)
American Depositary Shares
Indirect
183 shares at avg. $94.00-
GPCR
Structure Therapeutics Inc.
Dec 8, 2025
Sale(S)
American Depositary Shares
Indirect
8.3K shares at avg. $92.52-
GPCR
Structure Therapeutics Inc.
Dec 8, 2025
Sale(S)
American Depositary Shares
Indirect
5.6K shares at avg. $94.61-
GPCR
Structure Therapeutics Inc.
Dec 8, 2025
Sale(S)
American Depositary Shares
Indirect
16.6K shares at avg. $61.05-
GPCR
Structure Therapeutics Inc.
Dec 8, 2025
Sale(S)
American Depositary Shares
Indirect
15.5K shares at avg. $61.45-

		Type	Shares	Price		Ownership
Jul 22, 2026	GPCR Structure Therapeutics Inc.	Sale(S) American Depositary Shares	1,367	$50.07	-	Indirect
Jul 22, 2026	GPCR Structure Therapeutics Inc.	Sale(S) American Depositary Shares	16,085	$50.07	-	Indirect
Jun 26, 2026	BEAM Beam Therapeutics Inc.	Sale(S)	251,488	$35.26	$8,867,467	Indirect
Jun 25, 2026	BEAM Beam Therapeutics Inc.	Sale(S)	33,372	$35.12	$1,172,025	Indirect
May 1, 2026	AVLN Avalyn Pharma Inc.	Conversion(C)	225,843	-	$0	Indirect
May 1, 2026	AVLN Avalyn Pharma Inc.	Conversion(C)	872,868	-	$0	Indirect
May 1, 2026	AVLN Avalyn Pharma Inc.	Conversion(C)	377,948	-	$0	Indirect
May 1, 2026	AVLN Avalyn Pharma Inc.	Conversion(C)	727,585	-	$0	Indirect
May 1, 2026	AVLN Avalyn Pharma Inc.	Conversion(C)	80,291	-	$0	Indirect
Apr 14, 2026	GPCR Structure Therapeutics Inc.	Sale(S) American Depositary Shares	16,085	$55.07	-	Indirect
Apr 14, 2026	GPCR Structure Therapeutics Inc.	Sale(S) American Depositary Shares	1,367	$55.07	-	Indirect
Jan 15, 2026	GPCR Structure Therapeutics Inc.	Sale(S) American Depositary Shares	6,498	$84.22	-	Indirect
Jan 15, 2026	GPCR Structure Therapeutics Inc.	Sale(S) American Depositary Shares	230	$85.04	-	Indirect
Jan 15, 2026	GPCR Structure Therapeutics Inc.	Sale(S) American Depositary Shares	330	$83.35	-	Indirect
Jan 15, 2026	GPCR Structure Therapeutics Inc.	Sale(S) American Depositary Shares	5,477	$82.10	-	Indirect
Jan 15, 2026	GPCR Structure Therapeutics Inc.	Sale(S) American Depositary Shares	465	$82.10	-	Indirect
Jan 15, 2026	GPCR Structure Therapeutics Inc.	Sale(S) American Depositary Shares	552	$84.22	-	Indirect
Jan 15, 2026	GPCR Structure Therapeutics Inc.	Sale(S) American Depositary Shares	20	$85.04	-	Indirect
Jan 15, 2026	GPCR Structure Therapeutics Inc.	Sale(S) American Depositary Shares	3,880	$83.35	-	Indirect
Dec 8, 2025	GPCR Structure Therapeutics Inc.	Sale(S) American Depositary Shares	709	$92.52	-	Indirect
Dec 8, 2025	GPCR Structure Therapeutics Inc.	Sale(S) American Depositary Shares	183	$94.00	-	Indirect
Dec 8, 2025	GPCR Structure Therapeutics Inc.	Sale(S) American Depositary Shares	8,337	$92.52	-	Indirect
Dec 8, 2025	GPCR Structure Therapeutics Inc.	Sale(S) American Depositary Shares	5,589	$94.61	-	Indirect
Dec 8, 2025	GPCR Structure Therapeutics Inc.	Sale(S) American Depositary Shares	16,635	$61.05	-	Indirect
Dec 8, 2025	GPCR Structure Therapeutics Inc.	Sale(S) American Depositary Shares	15,535	$61.45	-	Indirect

1-25 of 64 transactions

About FMR LLC

FMR LLC (SEC CIK 0000315066) files insider reports with the SEC as 10% Owner of Structure Therapeutics Inc. (GPCR), 10% Owner of Beam Therapeutics Inc. (BEAM) and 10% Owner of Avalyn Pharma Inc. (AVLN). Signal8 also holds filings tied to 4 other companies.

Signal8 holds 26 ownership filings by FMR LLC (6 Form 3, 20 Form 4), filed between Sep 12, 2024 and Jul 24, 2026. Those filings report 64 transactions, from Sep 16, 2024 to Jul 22, 2026. Signal8's Form 4 history starts in Sep 2024.

The business address on FMR LLC's filings is in BOSTON, MA.

Recent filings by FMR LLC

Jul 22, 2026: Open-market sales of GPCR derivative securities (2 lines, Form 4, code S).
Jun 26, 2026: Open-market sale of BEAM shares (Form 4, code S).
Jun 25, 2026: Open-market sale of BEAM shares (Form 4, code S).
May 1, 2026: Conversions of AVLN shares (5 lines, Form 4, code C).
Apr 14, 2026: Open-market sales of GPCR derivative securities (2 lines, Form 4, code S).

Other insiders filing for Structure Therapeutics Inc. (GPCR)

Coll Crespo Blas, CHIEF MEDICAL OFFICER
Lin Xichen, CHIEF SCIENTIFIC OFFICER
Berrios John Joseph, Chief Commercial Officer
Russell Angus C., Director
LOVE TED W, Director
Waldstreicher Joanne, Director

How to read Form 4 transaction codes