Perceptive Advisors LLC

CIK: 0001224962

Transaction Breakdown

Open Market Buys (P)7 (14.6%)

High conviction signal

Open Market Sales (S)18 (37.5%)

Position reduction

Option Exercises (M)1 (2.1%)

Derivative conversions

Awards (A)19 (39.6%)

Compensation grants

Other (G, F, J, C, D, …)3 (6.3%)

Gifts, tax withholding, conversions, dispositions to the issuer and other codes

Companies & Roles (12)

LONA

LeonaBio, Inc.

Director10% Owner

IMTX

Immatics N.V.

Director

YARW

Yarrow Bioscience, Inc.

10% Owner

FRNM

Freenome, Inc.

10% Owner

KARD

Kardigan, Inc.

Director

MGTX

MeiraGTx Holdings plc

Director10% Owner

SLDB

Solid Biosciences Inc.

Director10% Owner

LYRA

Lyra Therapeutics, Inc.

10% Owner

ADGM

Adagio Medical Holdings, Inc.

Director10% Owner

OBIO

Orchestra BioMed Holdings, Inc.

10% Owner

ACRV

Acrivon Therapeutics, Inc.

10% Owner

ALDX

Aldeyra Therapeutics, Inc.

10% Owner

Discretionary Trading P&L

Holdings

Transaction History (48 total)

LONA
LeonaBio, Inc.
Oct 26, 2026
Exercise(M)
Indirect
776.6K shares at avg. $0.00$776.648
IMTX
Immatics N.V.
Aug 26, 2026
Purchase(P)
Indirect
863.1K shares at avg. $8.69$7.5M
FRNM
Freenome, Inc.
Jul 20, 2026
Award(A)
Indirect
5.5M shares at avg. $10.00$55.0M
LONA
LeonaBio, Inc.
Jun 23, 2026
Award(A)
Stock Option (Right to Buy)
Indirect
28K shares-
KARD
Kardigan, Inc.
Jun 17, 2026
Award(A)
Indirect
20.7K shares-
IMTX
Immatics N.V.
Jun 16, 2026
Award(A)
Stock Option (Right to Buy)
Indirect
48K shares-
MGTX
MeiraGTx Holdings plc
Jun 11, 2026
Award(A)
Restricted Share Units
Indirect
60K shares-
SLDB
Solid Biosciences Inc.
Jun 10, 2026
Award(A)
Director Stock Option (Right to Buy)
Indirect
77.5K shares-
MGTX
MeiraGTx Holdings plc
Apr 17, 2026
Award(A)
Indirect
555.6K shares at avg. $9.00$5.0M
LONA
LeonaBio, Inc.
Apr 9, 2026
Award(A)
Stock Option (Right to Buy)
Indirect
28K shares-
MGTX
MeiraGTx Holdings plc
Mar 25, 2026
Disposition(D)
Warrant (Right to Buy)
Indirect
400K shares-
MGTX
MeiraGTx Holdings plc
Mar 25, 2026
Disposition(D)
Warrant (Right to Buy)
Indirect
300K shares-
MGTX
MeiraGTx Holdings plc
Mar 25, 2026
Award(A)
Warrant (Right to Buy)
Indirect
400K shares-
MGTX
MeiraGTx Holdings plc
Mar 25, 2026
Award(A)
Warrant (Right to Buy)
Indirect
300K shares-
SLDB
Solid Biosciences Inc.
Mar 9, 2026
Award(A)
Pre-Funded Warrant (right to buy)
Indirect
8.9M shares at avg. $5.61-
MGTX
MeiraGTx Holdings plc
Dec 31, 2025
Disposition(D)
Indirect
2.3M shares at avg. $7.91$18.2M
ATHA
Athira Pharma, Inc.
Dec 23, 2025
Award(A)
Indirect
989.3K shares at avg. $6.35$6.3M
ATHA
Athira Pharma, Inc.
Dec 23, 2025
Award(A)
Indirect
329.8K shares at avg. $6.35$2.1M
LYRA
Lyra Therapeutics, Inc.
Nov 13, 2025
Sale(S)
Indirect
28.6K shares at avg. $3.90$112K
LYRA
Lyra Therapeutics, Inc.
Nov 13, 2025
Sale(S)
Indirect
3.2K shares at avg. $3.90$13K
LYRA
Lyra Therapeutics, Inc.
Nov 12, 2025
Sale(S)
Indirect
883 shares at avg. $4.06$4K
LYRA
Lyra Therapeutics, Inc.
Nov 12, 2025
Sale(S)
Indirect
7.9K shares at avg. $4.06$32K
LYRA
Lyra Therapeutics, Inc.
Nov 11, 2025
Sale(S)
Indirect
4.8K shares at avg. $4.31$21K
LYRA
Lyra Therapeutics, Inc.
Nov 11, 2025
Sale(S)
Indirect
537 shares at avg. $4.31$2K
LYRA
Lyra Therapeutics, Inc.
Nov 10, 2025
Sale(S)
Indirect
16.6K shares at avg. $4.54$76K

		Type	Shares	Price		Ownership
Oct 26, 2026	LONA LeonaBio, Inc.	Exercise(M)	776,648	$0.00	$777	Indirect
Aug 26, 2026	IMTX Immatics N.V.	Purchase(P)	863,060	$8.69	$7,499,991	Indirect
Jul 20, 2026	FRNM Freenome, Inc.	Award(A)	5,500,000	$10.00	$55,000,000	Indirect
Jun 23, 2026	LONA LeonaBio, Inc.	Award(A) Stock Option (Right to Buy)	28,000	-	-	Indirect
Jun 17, 2026	KARD Kardigan, Inc.	Award(A)	20,706	-	$0	Indirect
Jun 16, 2026	IMTX Immatics N.V.	Award(A) Stock Option (Right to Buy)	48,000	-	-	Indirect
Jun 11, 2026	MGTX MeiraGTx Holdings plc	Award(A) Restricted Share Units	60,000	-	-	Indirect
Jun 10, 2026	SLDB Solid Biosciences Inc.	Award(A) Director Stock Option (Right to Buy)	77,500	-	-	Indirect
Apr 17, 2026	MGTX MeiraGTx Holdings plc	Award(A)	555,555	$9.00	$4,999,995	Indirect
Apr 9, 2026	LONA LeonaBio, Inc.	Award(A) Stock Option (Right to Buy)	28,000	-	-	Indirect
Mar 25, 2026	MGTX MeiraGTx Holdings plc	Disposition(D) Warrant (Right to Buy)	400,000	-	-	Indirect
Mar 25, 2026	MGTX MeiraGTx Holdings plc	Disposition(D) Warrant (Right to Buy)	300,000	-	-	Indirect
Mar 25, 2026	MGTX MeiraGTx Holdings plc	Award(A) Warrant (Right to Buy)	400,000	-	-	Indirect
Mar 25, 2026	MGTX MeiraGTx Holdings plc	Award(A) Warrant (Right to Buy)	300,000	-	-	Indirect
Mar 9, 2026	SLDB Solid Biosciences Inc.	Award(A) Pre-Funded Warrant (right to buy)	8,912,655	$5.61	-	Indirect
Dec 31, 2025	MGTX MeiraGTx Holdings plc	Disposition(D)	2,300,000	$7.91	$18,193,000	Indirect
Dec 23, 2025	ATHA Athira Pharma, Inc.	Award(A)	989,270	$6.35	$6,281,865	Indirect
Dec 23, 2025	ATHA Athira Pharma, Inc.	Award(A)	329,756	$6.35	$2,093,951	Indirect
Nov 13, 2025	LYRA Lyra Therapeutics, Inc.	Sale(S)	28,597	$3.90	$111,531	Indirect
Nov 13, 2025	LYRA Lyra Therapeutics, Inc.	Sale(S)	3,213	$3.90	$12,531	Indirect
Nov 12, 2025	LYRA Lyra Therapeutics, Inc.	Sale(S)	883	$4.06	$3,584	Indirect
Nov 12, 2025	LYRA Lyra Therapeutics, Inc.	Sale(S)	7,862	$4.06	$31,915	Indirect
Nov 11, 2025	LYRA Lyra Therapeutics, Inc.	Sale(S)	4,783	$4.31	$20,637	Indirect
Nov 11, 2025	LYRA Lyra Therapeutics, Inc.	Sale(S)	537	$4.31	$2,317	Indirect
Nov 10, 2025	LYRA Lyra Therapeutics, Inc.	Sale(S)	16,633	$4.54	$75,510	Indirect

1-25 of 48 transactions

About PERCEPTIVE ADVISORS LLC

PERCEPTIVE ADVISORS LLC (SEC CIK 0001224962) files insider reports with the SEC as Director of LeonaBio, Inc. (LONA), Director of Immatics N.V. (IMTX) and 10% Owner of Yarrow Bioscience, Inc. (YARW). Signal8 also holds filings tied to 9 other companies.

Signal8 holds 29 ownership filings by PERCEPTIVE ADVISORS LLC (4 Form 3, 25 Form 4), filed between Nov 19, 2024 and Oct 26, 2026. Those filings report 48 transactions, from Aug 2, 2022 to Oct 26, 2026. Signal8's Form 4 history starts in Sep 2024.

The business address on PERCEPTIVE ADVISORS LLC's filings is in NEW YORK, NY.

Recent filings by PERCEPTIVE ADVISORS LLC

Oct 26, 2026: Option exercise of LONA shares (Form 4, code M).
Aug 26, 2026: Open-market purchase of IMTX shares (Form 4, code P).
Jul 20, 2026: Grant or award of FRNM shares (Form 4, code A).
Jun 23, 2026: Grant or award of LONA derivative securities (Form 4, code A).
Jun 17, 2026: Grant or award of KARD shares (Form 4, code A).

Other insiders filing for LeonaBio, Inc. (LONA)

Portman David J., 10% Owner
Callori Fred, Director
Holles Natalie C., Director
Silverman Peter B., Director
Panzara Michael A., Director
Romano Kelly A, Director

How to read Form 4 transaction codes