Opaleye Management Inc.

CIK: 0001595855

Transaction Breakdown

Open Market Buys (P)182 (75.8%)

High conviction signal

Open Market Sales (S)58 (24.2%)

Position reduction

Option Exercises (M)0 (0.0%)

Derivative conversions

Awards (A)0 (0.0%)

Compensation grants

Other (G, F, J, C, D, …)0 (0.0%)

Gifts, tax withholding, conversions, dispositions to the issuer and other codes

Companies & Roles (8)

ACOG

Alpha Cognition Inc.

10% Owner

GRCE

Grace Therapeutics, Inc.

10% Owner

SLGL

Sol-Gel Technologies Ltd.

10% Owner

ETON

Eton Pharmaceuticals, Inc.

10% Owner

SNWV

SANUWAVE Health, Inc.

10% Owner

HROW

HARROW, INC.

10% Owner

CDXS

CODEXIS, INC.

10% Owner

TARA

Protara Therapeutics, Inc.

10% Owner

Discretionary Trading P&L

Holdings

Transaction History (240 total)

GRCE
Grace Therapeutics, Inc.
Oct 26, 2026
Purchase(P)
Indirect
66.4K shares at avg. $1.77$117K
ACOG
Alpha Cognition Inc.
Oct 23, 2026
Purchase(P)
Indirect
15K shares at avg. $8.23$123K
GRCE
Grace Therapeutics, Inc.
Oct 22, 2026
Purchase(P)
Indirect
21.4K shares at avg. $1.93$41K
ACOG
Alpha Cognition Inc.
Oct 22, 2026
Purchase(P)
Indirect
17.1K shares at avg. $8.33$143K
GRCE
Grace Therapeutics, Inc.
Oct 19, 2026
Purchase(P)
Indirect
4.3K shares at avg. $1.88$8K
ACOG
Alpha Cognition Inc.
Oct 16, 2026
Purchase(P)
Indirect
14.3K shares at avg. $8.23$118K
GRCE
Grace Therapeutics, Inc.
Oct 16, 2026
Purchase(P)
Indirect
36.3K shares at avg. $1.89$69K
ACOG
Alpha Cognition Inc.
Oct 15, 2026
Purchase(P)
Indirect
22.7K shares at avg. $8.43$191K
GRCE
Grace Therapeutics, Inc.
Oct 15, 2026
Purchase(P)
Indirect
23.5K shares at avg. $1.95$46K
GRCE
Grace Therapeutics, Inc.
Oct 14, 2026
Purchase(P)
Indirect
11.2K shares at avg. $1.93$22K
GRCE
Grace Therapeutics, Inc.
Oct 12, 2026
Purchase(P)
Indirect
7.2K shares at avg. $2.02$15K
GRCE
Grace Therapeutics, Inc.
Oct 9, 2026
Purchase(P)
Indirect
5.3K shares at avg. $2.04$11K
GRCE
Grace Therapeutics, Inc.
Oct 8, 2026
Purchase(P)
Indirect
2.1K shares at avg. $2.02$4K
GRCE
Grace Therapeutics, Inc.
Oct 5, 2026
Purchase(P)
Indirect
1.7K shares at avg. $2.06$3K
GRCE
Grace Therapeutics, Inc.
Oct 2, 2026
Purchase(P)
Indirect
20K shares at avg. $2.07$41K
GRCE
Grace Therapeutics, Inc.
Oct 1, 2026
Purchase(P)
Indirect
38.8K shares at avg. $2.04$79K
ACOG
Alpha Cognition Inc.
Oct 1, 2026
Purchase(P)
Indirect
19.1K shares at avg. $8.69$166K
GRCE
Grace Therapeutics, Inc.
Sep 29, 2026
Purchase(P)
Indirect
7.8K shares at avg. $2.09$16K
ACOG
Alpha Cognition Inc.
Sep 25, 2026
Purchase(P)
Indirect
13.4K shares at avg. $8.47$114K
ACOG
Alpha Cognition Inc.
Sep 24, 2026
Purchase(P)
Indirect
18.3K shares at avg. $8.57$157K
GRCE
Grace Therapeutics, Inc.
Sep 23, 2026
Purchase(P)
Indirect
5.3K shares at avg. $2.10$11K
GRCE
Grace Therapeutics, Inc.
Sep 21, 2026
Purchase(P)
Indirect
9.8K shares at avg. $2.10$21K
ACOG
Alpha Cognition Inc.
Sep 16, 2026
Purchase(P)
Indirect
53K shares at avg. $8.57$455K
ACOG
Alpha Cognition Inc.
Sep 16, 2026
Purchase(P)
Indirect
27.1K shares at avg. $8.40$228K
ACOG
Alpha Cognition Inc.
Sep 15, 2026
Purchase(P)
Indirect
3.4K shares at avg. $8.54$29K

		Type	Shares	Price		Ownership
Oct 26, 2026	GRCE Grace Therapeutics, Inc.	Purchase(P)	66,411	$1.77	$117,408	Indirect
Oct 23, 2026	ACOG Alpha Cognition Inc.	Purchase(P)	14,973	$8.23	$123,294	Indirect
Oct 22, 2026	GRCE Grace Therapeutics, Inc.	Purchase(P)	21,390	$1.93	$41,193	Indirect
Oct 22, 2026	ACOG Alpha Cognition Inc.	Purchase(P)	17,117	$8.33	$142,526	Indirect
Oct 19, 2026	GRCE Grace Therapeutics, Inc.	Purchase(P)	4,256	$1.88	$8,001	Indirect
Oct 16, 2026	ACOG Alpha Cognition Inc.	Purchase(P)	14,283	$8.23	$117,602	Indirect
Oct 16, 2026	GRCE Grace Therapeutics, Inc.	Purchase(P)	36,347	$1.89	$68,758	Indirect
Oct 15, 2026	ACOG Alpha Cognition Inc.	Purchase(P)	22,657	$8.43	$190,974	Indirect
Oct 15, 2026	GRCE Grace Therapeutics, Inc.	Purchase(P)	23,485	$1.95	$45,685	Indirect
Oct 14, 2026	GRCE Grace Therapeutics, Inc.	Purchase(P)	11,233	$1.93	$21,735	Indirect
Oct 12, 2026	GRCE Grace Therapeutics, Inc.	Purchase(P)	7,215	$2.02	$14,574	Indirect
Oct 9, 2026	GRCE Grace Therapeutics, Inc.	Purchase(P)	5,340	$2.04	$10,918	Indirect
Oct 8, 2026	GRCE Grace Therapeutics, Inc.	Purchase(P)	2,077	$2.02	$4,190	Indirect
Oct 5, 2026	GRCE Grace Therapeutics, Inc.	Purchase(P)	1,694	$2.06	$3,490	Indirect
Oct 2, 2026	GRCE Grace Therapeutics, Inc.	Purchase(P)	20,000	$2.07	$41,368	Indirect
Oct 1, 2026	GRCE Grace Therapeutics, Inc.	Purchase(P)	38,796	$2.04	$78,961	Indirect
Oct 1, 2026	ACOG Alpha Cognition Inc.	Purchase(P)	19,050	$8.69	$165,634	Indirect
Sep 29, 2026	GRCE Grace Therapeutics, Inc.	Purchase(P)	7,849	$2.09	$16,404	Indirect
Sep 25, 2026	ACOG Alpha Cognition Inc.	Purchase(P)	13,426	$8.47	$113,718	Indirect
Sep 24, 2026	ACOG Alpha Cognition Inc.	Purchase(P)	18,337	$8.57	$157,082	Indirect
Sep 23, 2026	GRCE Grace Therapeutics, Inc.	Purchase(P)	5,318	$2.10	$11,168	Indirect
Sep 21, 2026	GRCE Grace Therapeutics, Inc.	Purchase(P)	9,771	$2.10	$20,519	Indirect
Sep 16, 2026	ACOG Alpha Cognition Inc.	Purchase(P)	53,029	$8.57	$454,607	Indirect
Sep 16, 2026	ACOG Alpha Cognition Inc.	Purchase(P)	27,141	$8.40	$227,984	Indirect
Sep 15, 2026	ACOG Alpha Cognition Inc.	Purchase(P)	3,375	$8.54	$28,831	Indirect

1-25 of 240 transactions

…

About Opaleye Management Inc.

Opaleye Management Inc. (SEC CIK 0001595855) files insider reports with the SEC as 10% Owner of Alpha Cognition Inc. (ACOG), 10% Owner of Grace Therapeutics, Inc. (GRCE) and 10% Owner of Sol-Gel Technologies Ltd. (SLGL). Signal8 also holds filings tied to 5 other companies.

Signal8 holds 117 ownership filings by Opaleye Management Inc. (4 Form 3, 113 Form 4), filed between Sep 10, 2024 and Oct 26, 2026. Those filings report 240 transactions, from Sep 9, 2024 to Oct 26, 2026. Signal8's Form 4 history starts in Sep 2024.

The business address on Opaleye Management Inc.'s filings is in BOSTON, MA.

Recent filings by Opaleye Management Inc.

Oct 26, 2026: Open-market purchase of GRCE shares (Form 4, code P).
Oct 23, 2026: Open-market purchase of ACOG shares (Form 4, code P).
Oct 22, 2026: Open-market purchase of GRCE shares (Form 4, code P).
Oct 22, 2026: Open-market purchase of ACOG shares (Form 4, code P).
Oct 19, 2026: Open-market purchase of GRCE shares (Form 4, code P).

Other insiders filing for Alpha Cognition Inc. (ACOG)

Wills Robert James, Director
D'Angelo Lauren, Chief Operating Officer
Sensenig Bethany, Director
MERTZ PHILLIP JOSEPH, Director
MERTZ LEONARD POWELL, Director
CAWKELL KENNETH ANTHONY, Director

How to read Form 4 transaction codes