Isaac Manke
CIK: 0001622769
Transaction Breakdown
High conviction signal
Position reduction
Derivative conversions
Compensation grants
Gifts, tax withholding, conversions, dispositions to the issuer and other codes
Discretionary Trading P&L
Holdings
Transaction History (23 total)
- Sep 2, 2026ADXN
Addex Therapeutics Ltd.
Disposition(D)Direct219.6K shares- - Sep 2, 2026ADXN
Addex Therapeutics Ltd.
Award(A)Direct219.6K shares- - Aug 7, 2026OKUR
OnKure Therapeutics, Inc.
Award(A)DirectStock Option (right to buy)
300K shares- - Aug 7, 2026OKUR
OnKure Therapeutics, Inc.
Award(A)DirectStock Option (right to buy)
15.3K shares- - Aug 7, 2026OKUR
OnKure Therapeutics, Inc.
Disposition(D)DirectStock Option (right to buy)
15.3K shares- - Jun 30, 2026QTTB
Q32 Bio Inc.
Exercise(M)Direct53.5K shares at avg. $2.80$150K - Jun 12, 2026QTTB
Q32 Bio Inc.
Award(A)DirectStock Option (Right to Buy)
10.8K shares- - Jun 12, 2026QTTB
Q32 Bio Inc.
Award(A)DirectStock Option (Right to Buy)
9.8K shares- - Dec 31, 2025OKUR
OnKure Therapeutics, Inc.
Award(A)Direct5.3K shares- - Oct 23, 2025QTTB
Q32 Bio Inc.
Award(A)DirectStock Option (Right to Buy)
53.5K shares- - Sep 30, 2025OKUR
OnKure Therapeutics, Inc.
Award(A)Direct5.5K shares- - Jun 30, 2025OKUR
OnKure Therapeutics, Inc.
Award(A)Direct6.3K shares- - May 28, 2025OKUR
OnKure Therapeutics, Inc.
Award(A)DirectStock Option (right to buy)
7.7K shares- - Mar 31, 2025OKUR
OnKure Therapeutics, Inc.
Award(A)Direct3.5K shares- - Feb 24, 2025QTTB
Q32 Bio Inc.
Award(A)DirectStock Option (Right to Buy)
12.8K shares- - Feb 24, 2025QTTB
Q32 Bio Inc.
Disposition(D)DirectStock Option (Right to Buy)
2.6K shares- - Feb 24, 2025QTTB
Q32 Bio Inc.
Disposition(D)DirectStock Option (Right to Buy)
12.8K shares- - Feb 24, 2025QTTB
Q32 Bio Inc.
Award(A)DirectStock Option (Right to Buy)
2.6K shares- - Feb 24, 2025QTTB
Q32 Bio Inc.
Disposition(D)DirectStock Option (Right to Buy)
19K shares- - Feb 24, 2025QTTB
Q32 Bio Inc.
Award(A)DirectStock Option (Right to Buy)
19K shares- - Jan 15, 2025QTTB
Q32 Bio Inc.
Award(A)DirectStock Option (Right to Buy)
19K shares- - Oct 4, 2024OKUR
OnKure Therapeutics, Inc.
Award(A)DirectStock Option (right to buy)
15.3K shares- - Apr 1, 2024QTTB
Q32 Bio Inc.
Award(A)DirectStock Option (Right to Buy)
2.6K shares at avg. $13.42-
| Type | Shares | Price | Ownership | |||
|---|---|---|---|---|---|---|
| Sep 2, 2026 |  ADXN Addex Therapeutics Ltd. | Disposition(D) | 219,561 | - | $0 | Direct |
| Sep 2, 2026 | ADXN Addex Therapeutics Ltd. | Award(A) | 219,561 | - | $0 | Direct |
| Aug 7, 2026 |  OKUR OnKure Therapeutics, Inc. | Award(A) Stock Option (right to buy) | 300,000 | - | - | Direct |
| Aug 7, 2026 | OKUR OnKure Therapeutics, Inc. | Award(A) Stock Option (right to buy) | 15,300 | - | - | Direct |
| Aug 7, 2026 | OKUR OnKure Therapeutics, Inc. | Disposition(D) Stock Option (right to buy) | 15,300 | - | - | Direct |
| Jun 30, 2026 |  QTTB Q32 Bio Inc. | Exercise(M) | 53,521 | $2.80 | $149,859 | Direct |
| Jun 12, 2026 | QTTB Q32 Bio Inc. | Award(A) Stock Option (Right to Buy) | 10,826 | - | - | Direct |
| Jun 12, 2026 | QTTB Q32 Bio Inc. | Award(A) Stock Option (Right to Buy) | 9,810 | - | - | Direct |
| Dec 31, 2025 | OKUR OnKure Therapeutics, Inc. | Award(A) | 5,258 | - | $0 | Direct |
| Oct 23, 2025 | QTTB Q32 Bio Inc. | Award(A) Stock Option (Right to Buy) | 53,521 | - | - | Direct |
| Sep 30, 2025 | OKUR OnKure Therapeutics, Inc. | Award(A) | 5,545 | - | - | Direct |
| Jun 30, 2025 | OKUR OnKure Therapeutics, Inc. | Award(A) | 6,311 | - | - | Direct |
| May 28, 2025 | OKUR OnKure Therapeutics, Inc. | Award(A) Stock Option (right to buy) | 7,650 | - | - | Direct |
| Mar 31, 2025 | OKUR OnKure Therapeutics, Inc. | Award(A) | 3,469 | - | - | Direct |
| Feb 24, 2025 | QTTB Q32 Bio Inc. | Award(A) Stock Option (Right to Buy) | 12,767 | - | - | Direct |
| Feb 24, 2025 | QTTB Q32 Bio Inc. | Disposition(D) Stock Option (Right to Buy) | 2,627 | - | - | Direct |
| Feb 24, 2025 | QTTB Q32 Bio Inc. | Disposition(D) Stock Option (Right to Buy) | 12,767 | - | - | Direct |
| Feb 24, 2025 | QTTB Q32 Bio Inc. | Award(A) Stock Option (Right to Buy) | 2,627 | - | - | Direct |
| Feb 24, 2025 | QTTB Q32 Bio Inc. | Disposition(D) Stock Option (Right to Buy) | 19,008 | - | - | Direct |
| Feb 24, 2025 | QTTB Q32 Bio Inc. | Award(A) Stock Option (Right to Buy) | 19,008 | - | - | Direct |
| Jan 15, 2025 | QTTB Q32 Bio Inc. | Award(A) Stock Option (Right to Buy) | 19,008 | - | - | Direct |
| Oct 4, 2024 | OKUR OnKure Therapeutics, Inc. | Award(A) Stock Option (right to buy) | 15,300 | - | - | Direct |
| Apr 1, 2024 | QTTB Q32 Bio Inc. | Award(A) Stock Option (Right to Buy) | 2,627 | $13.42 | - | Direct |
1-23 of 23 transactions
About Manke Isaac
Manke Isaac (SEC CIK 0001622769) files insider reports with the SEC as Director of Addex Therapeutics Ltd. (ADXN), Director of Rainier Acquisition Corp (RNAQ) and Director of OnKure Therapeutics, Inc. (OKUR). Signal8 also holds filings tied to 1 other company.
Signal8 holds 18 ownership filings by Manke Isaac (3 Form 3, 15 Form 4), filed between Sep 30, 2024 and Sep 4, 2026. Those filings report 23 transactions, from Apr 1, 2024 to Sep 2, 2026. Signal8's Form 4 history starts in Sep 2024.
The business address on Manke Isaac's filings is in DORADO, PR.
Recent filings by Manke Isaac
- Sep 2, 2026: Disposition to issuer transaction of ADXN shares (Form 4, code D).
- Sep 2, 2026: Grant or award of ADXN shares (Form 4, code A).
- Aug 7, 2026: Grants or awards of OKUR derivative securities (2 lines, Form 4, code A).
- Aug 7, 2026: Disposition to issuer transaction of OKUR derivative securities (Form 4, code D).
- Jun 30, 2026: Option exercise of QTTB shares (Form 4, code M).
Other insiders filing for Addex Therapeutics Ltd. (ADXN)
- Teyssedou Lenaic Nathanael, PRINCIPAL ACCOUNTING OFFICER
- Kalinichev Mikhail, HEAD OF TRANSLATIONAL SCIENCE
- Nunn Jason Raleigh, Director
- Mills Roger, CHIEF MEDICAL OFFICER
- Lawton Vincent Michael, Director
- Hill Raymond George, Director