Kristen Ambrose

CIK: 0001856587

Transaction Breakdown

Open Market Buys (P)0 (0.0%)

High conviction signal

Open Market Sales (S)8 (34.8%)

Position reduction

Option Exercises (M)0 (0.0%)

Derivative conversions

Awards (A)7 (30.4%)

Compensation grants

Other (G, F, J, C, D, …)8 (34.8%)

Gifts, tax withholding, conversions, dispositions to the issuer and other codes

Companies & Roles (1)

VRTX

VERTEX PHARMACEUTICALS INC / MA

Officer

Discretionary Trading P&L

Holdings

Transaction History (23 total)

VRTX
VERTEX PHARMACEUTICALS INC / MA
Aug 28, 2026
Award(A)
Direct
5K shares-
VRTX
VERTEX PHARMACEUTICALS INC / MA
Feb 26, 2026
Sale(S)
Direct
357 shares at avg. $483.36$173K
VRTX
VERTEX PHARMACEUTICALS INC / MA
Feb 25, 2026
Sale(S)
Direct
223 shares at avg. $486.35$108K
VRTX
VERTEX PHARMACEUTICALS INC / MA
Feb 24, 2026
Tax Payment(F)
Direct
546 shares at avg. $485.11$265K
VRTX
VERTEX PHARMACEUTICALS INC / MA
Feb 18, 2026
Sale(S)
Direct
638 shares at avg. $473.68$302K
VRTX
VERTEX PHARMACEUTICALS INC / MA
Feb 17, 2026
Tax Payment(F)
Direct
598 shares at avg. $483.75$289K
VRTX
VERTEX PHARMACEUTICALS INC / MA
Feb 17, 2026
Sale(S)
Direct
1.6K shares at avg. $489.46$762K
VRTX
VERTEX PHARMACEUTICALS INC / MA
Feb 17, 2026
Award(A)
Direct
1.8K shares-
VRTX
VERTEX PHARMACEUTICALS INC / MA
Feb 13, 2026
Tax Payment(F)
Direct
1.4K shares at avg. $487.76$679K
VRTX
VERTEX PHARMACEUTICALS INC / MA
Feb 11, 2026
Sale(S)
Direct
1.4K shares at avg. $460.43$634K
VRTX
VERTEX PHARMACEUTICALS INC / MA
Feb 10, 2026
Tax Payment(F)
Direct
592 shares at avg. $468.41$277K
VRTX
VERTEX PHARMACEUTICALS INC / MA
Jan 22, 2026
Award(A)
Direct
1.3K shares-
VRTX
VERTEX PHARMACEUTICALS INC / MA
Jan 22, 2026
Award(A)
Direct
3K shares-
VRTX
VERTEX PHARMACEUTICALS INC / MA
Feb 26, 2025
Tax Payment(F)
Direct
1.2K shares at avg. $479.61$595K
VRTX
VERTEX PHARMACEUTICALS INC / MA
Feb 25, 2025
Sale(S)
Direct
884 shares at avg. $480.95$425K
VRTX
VERTEX PHARMACEUTICALS INC / MA
Feb 24, 2025
Tax Payment(F)
Direct
828 shares at avg. $483.28$400K
VRTX
VERTEX PHARMACEUTICALS INC / MA
Feb 18, 2025
Sale(S)
Direct
671 shares at avg. $455.06$305K
VRTX
VERTEX PHARMACEUTICALS INC / MA
Feb 14, 2025
Tax Payment(F)
Direct
564 shares at avg. $463.46$261K
VRTX
VERTEX PHARMACEUTICALS INC / MA
Feb 12, 2025
Award(A)
Direct
2.1K shares-
VRTX
VERTEX PHARMACEUTICALS INC / MA
Feb 11, 2025
Sale(S)
Direct
1.4K shares at avg. $459.83$633K
VRTX
VERTEX PHARMACEUTICALS INC / MA
Feb 10, 2025
Tax Payment(F)
Direct
591 shares at avg. $467.98$277K
VRTX
VERTEX PHARMACEUTICALS INC / MA
Feb 4, 2025
Award(A)
Direct
1.9K shares-
VRTX
VERTEX PHARMACEUTICALS INC / MA
Feb 4, 2025
Award(A)
Direct
2.6K shares-

		Type	Shares	Price		Ownership
Aug 28, 2026	VRTX VERTEX PHARMACEUTICALS INC / MA	Award(A)	5,000	-	$0	Direct
Feb 26, 2026	VRTX VERTEX PHARMACEUTICALS INC / MA	Sale(S)	357	$483.36	$172,560	Direct
Feb 25, 2026	VRTX VERTEX PHARMACEUTICALS INC / MA	Sale(S)	223	$486.35	$108,456	Direct
Feb 24, 2026	VRTX VERTEX PHARMACEUTICALS INC / MA	Tax Payment(F)	546	$485.11	$264,870	Direct
Feb 18, 2026	VRTX VERTEX PHARMACEUTICALS INC / MA	Sale(S)	638	$473.68	$302,208	Direct
Feb 17, 2026	VRTX VERTEX PHARMACEUTICALS INC / MA	Tax Payment(F)	598	$483.75	$289,283	Direct
Feb 17, 2026	VRTX VERTEX PHARMACEUTICALS INC / MA	Sale(S)	1,557	$489.46	$762,089	Direct
Feb 17, 2026	VRTX VERTEX PHARMACEUTICALS INC / MA	Award(A)	1,809	-	$0	Direct
Feb 13, 2026	VRTX VERTEX PHARMACEUTICALS INC / MA	Tax Payment(F)	1,393	$487.76	$679,450	Direct
Feb 11, 2026	VRTX VERTEX PHARMACEUTICALS INC / MA	Sale(S)	1,376	$460.43	$633,552	Direct
Feb 10, 2026	VRTX VERTEX PHARMACEUTICALS INC / MA	Tax Payment(F)	592	$468.41	$277,299	Direct
Jan 22, 2026	VRTX VERTEX PHARMACEUTICALS INC / MA	Award(A)	1,300	-	$0	Direct
Jan 22, 2026	VRTX VERTEX PHARMACEUTICALS INC / MA	Award(A)	2,950	-	$0	Direct
Feb 26, 2025	VRTX VERTEX PHARMACEUTICALS INC / MA	Tax Payment(F)	1,241	$479.61	$595,196	Direct
Feb 25, 2025	VRTX VERTEX PHARMACEUTICALS INC / MA	Sale(S)	884	$480.95	$425,160	Direct
Feb 24, 2025	VRTX VERTEX PHARMACEUTICALS INC / MA	Tax Payment(F)	828	$483.28	$400,156	Direct
Feb 18, 2025	VRTX VERTEX PHARMACEUTICALS INC / MA	Sale(S)	671	$455.06	$305,345	Direct
Feb 14, 2025	VRTX VERTEX PHARMACEUTICALS INC / MA	Tax Payment(F)	564	$463.46	$261,391	Direct
Feb 12, 2025	VRTX VERTEX PHARMACEUTICALS INC / MA	Award(A)	2,080	-	-	Direct
Feb 11, 2025	VRTX VERTEX PHARMACEUTICALS INC / MA	Sale(S)	1,376	$459.83	$632,726	Direct
Feb 10, 2025	VRTX VERTEX PHARMACEUTICALS INC / MA	Tax Payment(F)	591	$467.98	$276,576	Direct
Feb 4, 2025	VRTX VERTEX PHARMACEUTICALS INC / MA	Award(A)	1,854	-	-	Direct
Feb 4, 2025	VRTX VERTEX PHARMACEUTICALS INC / MA	Award(A)	2,566	-	-	Direct

1-23 of 23 transactions

About Ambrose Kristen

Ambrose Kristen (SEC CIK 0001856587) files insider reports with the SEC as SVP & Chief Accounting Officer of VERTEX PHARMACEUTICALS INC / MA (VRTX).

Signal8 holds 13 ownership filings by Ambrose Kristen, all Form 4s, filed between Feb 6, 2025 and Sep 1, 2026. Those filings report 23 transactions, from Feb 4, 2025 to Aug 28, 2026. Signal8's Form 4 history starts in Sep 2024.

The business address on Ambrose Kristen's filings is in BOSTON, MA.

Recent filings by Ambrose Kristen

Aug 28, 2026: Grant or award of VRTX shares (Form 4, code A).
Feb 26, 2026: Open-market sale of VRTX shares (Form 4, code S).
Feb 25, 2026: Open-market sale of VRTX shares (Form 4, code S).
Feb 24, 2026: Tax withholding of VRTX shares (Form 4, code F).
Feb 18, 2026: Open-market sale of VRTX shares (Form 4, code S).

Other insiders filing for VERTEX PHARMACEUTICALS INC / MA (VRTX)

Brennan Daniel J., Director
SACHS BRUCE I, Director
Garber Alan M, Director
van Grunsven Jasper, EVP, CP and NPPO
Tatsis Ourania, EVP, Chief Reg. & Quality Off.
Sachdev Amit, EVP Chief Patient & Ext Af Off

How to read Form 4 transaction codes