Brian Birchler

CIK: 0001970151

Transaction Breakdown

Open Market Buys (P)0 (0.0%)

High conviction signal

Open Market Sales (S)8 (30.8%)

Position reduction

Option Exercises (M)6 (23.1%)

Derivative conversions

Awards (A)7 (26.9%)

Compensation grants

Other (G, F, J, C, D, …)5 (19.2%)

Gifts, tax withholding, conversions, dispositions to the issuer and other codes

Companies & Roles (1)

IONS

IONIS PHARMACEUTICALS INC

Officer

Discretionary Trading P&L

Holdings

Transaction History (26 total)

IONS
IONIS PHARMACEUTICALS INC
Aug 31, 2026
Other(J)
Direct
58 shares at avg. $51.31$3K
IONS
IONIS PHARMACEUTICALS INC
Apr 16, 2026
Sale(S)
Direct
973 shares at avg. $75.04$73K
IONS
IONIS PHARMACEUTICALS INC
Apr 15, 2026
Exercise(M)
Direct
1.9K shares-
IONS
IONIS PHARMACEUTICALS INC
Feb 27, 2026
Other(J)
Direct
351 shares at avg. $48.87$17K
IONS
IONIS PHARMACEUTICALS INC
Jan 30, 2026
Sale(S)
Direct
6.2K shares at avg. $83.03$513K
IONS
IONIS PHARMACEUTICALS INC
Jan 29, 2026
Award(A)
Direct
12K shares-
IONS
IONIS PHARMACEUTICALS INC
Jan 16, 2026
Sale(S)
Direct
8.5K shares at avg. $75.11$637K
IONS
IONIS PHARMACEUTICALS INC
Jan 15, 2026
Award(A)
Restricted Stock Unit
Direct
9.7K shares-
IONS
IONIS PHARMACEUTICALS INC
Jan 15, 2026
Exercise(M)
Direct
20.1K shares-
IONS
IONIS PHARMACEUTICALS INC
Jan 15, 2026
Award(A)
Performance Restricted Stock Units
Direct
25.8K shares-
IONS
IONIS PHARMACEUTICALS INC
Jan 2, 2026
Award(A)
Non-Qualified Stock Option (right to buy)
Direct
19.4K shares-
IONS
IONIS PHARMACEUTICALS INC
Nov 6, 2025
Sale(S)
Direct
8K shares at avg. $76.17$609K
IONS
IONIS PHARMACEUTICALS INC
Oct 15, 2025
Exercise(M)
Direct
12.4K shares at avg. $53.77$668K
IONS
IONIS PHARMACEUTICALS INC
Oct 15, 2025
Sale(S)
Direct
12.4K shares at avg. $72.23$897K
IONS
IONIS PHARMACEUTICALS INC
Oct 14, 2025
Sale(S)
Direct
11.5K shares at avg. $72.03$827K
IONS
IONIS PHARMACEUTICALS INC
Oct 14, 2025
Exercise(M)
Direct
11.5K shares at avg. $53.77$617K
IONS
IONIS PHARMACEUTICALS INC
Aug 29, 2025
Other(J)
Direct
166 shares at avg. $27.71$5K
IONS
IONIS PHARMACEUTICALS INC
Apr 16, 2025
Sale(S)
Direct
680 shares at avg. $28.37$19K
IONS
IONIS PHARMACEUTICALS INC
Apr 15, 2025
Exercise(M)
Direct
1.9K shares-
IONS
IONIS PHARMACEUTICALS INC
Feb 28, 2025
Other(J)
Direct
414 shares at avg. $28.21$12K
IONS
IONIS PHARMACEUTICALS INC
Jan 16, 2025
Sale(S)
Direct
5.4K shares at avg. $32.70$177K
IONS
IONIS PHARMACEUTICALS INC
Jan 15, 2025
Award(A)
Performance Restricted Stock Units
Direct
22K shares-
IONS
IONIS PHARMACEUTICALS INC
Jan 15, 2025
Award(A)
Restricted Stock Unit
Direct
33K shares-
IONS
IONIS PHARMACEUTICALS INC
Jan 15, 2025
Exercise(M)
Direct
14.3K shares-
IONS
IONIS PHARMACEUTICALS INC
Jan 2, 2025
Award(A)
Non-Qualified Stock Option (right to buy)
Direct
22K shares-

		Type	Shares	Price		Ownership
Aug 31, 2026	IONS IONIS PHARMACEUTICALS INC	Other(J)	58	$51.31	$2,976	Direct
Apr 16, 2026	IONS IONIS PHARMACEUTICALS INC	Sale(S)	973	$75.04	$73,016	Direct
Apr 15, 2026	IONS IONIS PHARMACEUTICALS INC	Exercise(M)	1,875	-	$0	Direct
Feb 27, 2026	IONS IONIS PHARMACEUTICALS INC	Other(J)	351	$48.87	$17,152	Direct
Jan 30, 2026	IONS IONIS PHARMACEUTICALS INC	Sale(S)	6,179	$83.03	$513,048	Direct
Jan 29, 2026	IONS IONIS PHARMACEUTICALS INC	Award(A)	11,991	-	$0	Direct
Jan 16, 2026	IONS IONIS PHARMACEUTICALS INC	Sale(S)	8,480	$75.11	$636,933	Direct
Jan 15, 2026	IONS IONIS PHARMACEUTICALS INC	Award(A) Restricted Stock Unit	9,675	-	-	Direct
Jan 15, 2026	IONS IONIS PHARMACEUTICALS INC	Exercise(M)	20,089	-	$0	Direct
Jan 15, 2026	IONS IONIS PHARMACEUTICALS INC	Award(A) Performance Restricted Stock Units	25,800	-	-	Direct
Jan 2, 2026	IONS IONIS PHARMACEUTICALS INC	Award(A) Non-Qualified Stock Option (right to buy)	19,350	-	-	Direct
Nov 6, 2025	IONS IONIS PHARMACEUTICALS INC	Sale(S)	8,000	$76.17	$609,379	Direct
Oct 15, 2025	IONS IONIS PHARMACEUTICALS INC	Exercise(M)	12,425	$53.77	$668,092	Direct
Oct 15, 2025	IONS IONIS PHARMACEUTICALS INC	Sale(S)	12,425	$72.23	$897,398	Direct
Oct 14, 2025	IONS IONIS PHARMACEUTICALS INC	Sale(S)	11,475	$72.03	$826,589	Direct
Oct 14, 2025	IONS IONIS PHARMACEUTICALS INC	Exercise(M)	11,475	$53.77	$617,011	Direct
Aug 29, 2025	IONS IONIS PHARMACEUTICALS INC	Other(J)	166	$27.71	$4,600	Direct
Apr 16, 2025	IONS IONIS PHARMACEUTICALS INC	Sale(S)	680	$28.37	$19,292	Direct
Apr 15, 2025	IONS IONIS PHARMACEUTICALS INC	Exercise(M)	1,875	-	-	Direct
Feb 28, 2025	IONS IONIS PHARMACEUTICALS INC	Other(J)	414	$28.21	$11,680	Direct
Jan 16, 2025	IONS IONIS PHARMACEUTICALS INC	Sale(S)	5,400	$32.70	$176,580	Direct
Jan 15, 2025	IONS IONIS PHARMACEUTICALS INC	Award(A) Performance Restricted Stock Units	22,000	-	-	Direct
Jan 15, 2025	IONS IONIS PHARMACEUTICALS INC	Award(A) Restricted Stock Unit	33,000	-	-	Direct
Jan 15, 2025	IONS IONIS PHARMACEUTICALS INC	Exercise(M)	14,283	-	$0	Direct
Jan 2, 2025	IONS IONIS PHARMACEUTICALS INC	Award(A) Non-Qualified Stock Option (right to buy)	22,000	-	-	Direct

1-25 of 26 transactions

About Birchler Brian

Birchler Brian (SEC CIK 0001970151) files insider reports with the SEC as EVP, Corp and Development Ops of IONIS PHARMACEUTICALS INC (IONS).

Signal8 holds 14 ownership filings by Birchler Brian, all Form 4s, filed between Sep 4, 2024 and Sep 2, 2026. Those filings report 26 transactions, from Aug 30, 2024 to Aug 31, 2026. Signal8's Form 4 history starts in Sep 2024.

The business address on Birchler Brian's filings is in CARLSBAD, CA.

Recent filings by Birchler Brian

Aug 31, 2026: Other transaction of IONS shares (Form 4, code J).
Apr 16, 2026: Open-market sale of IONS shares (Form 4, code S).
Apr 15, 2026: Option exercise of IONS shares (Form 4, code M).
Feb 27, 2026: Other transaction of IONS shares (Form 4, code J).
Jan 30, 2026: Open-market sale of IONS shares (Form 4, code S).

Other insiders filing for IONIS PHARMACEUTICALS INC (IONS)

Devers Shannon L., EVP, Chief Human Resources Ofc
Swayze Eric, EVP Research
BENNETT C FRANK, EVP, Chief Scientific Officer
O'NEIL PATRICK R., EVP CLO & General Counsel
Monia Brett P, Chief Executive Officer
Hayden Michael R, Director

How to read Form 4 transaction codes