Manke Isaac
SEC insider (Form 3/4/5 filer). CIK 0001622769. Director at Addex Therapeutics Ltd. (ADXN) and 3 other issuers. 23 reported Form 4/5 transactions since Sep 2024; latest on Sep 2, 2026. Located in DORADO, PR.
Companies Manke Isaac has filed insider reports for
- Addex Therapeutics Ltd. (ADXN): Director
- Rainier Acquisition Corp (RNAQ): Director
- OnKure Therapeutics, Inc. (OKUR): Director
- Q32 Bio Inc. (QTTB): Director
Manke Isaac
CIK: 0001622769
Transaction Breakdown
High conviction signal
Position reduction
Derivative conversions
Compensation grants
Gifts, tax withholding, conversions, dispositions to the issuer and other codes
Discretionary Trading P&L
Holdings
Transaction History (23 total)
- Sep 2, 2026ADXN
Addex Therapeutics Ltd.
DispositionDirect219.6K shares- - Sep 2, 2026ADXN
Addex Therapeutics Ltd.
AwardDirect219.6K shares- - Aug 7, 2026OKUR
OnKure Therapeutics, Inc.
AwardDirectStock Option (right to buy)
15.3K shares- - Aug 7, 2026OKUR
OnKure Therapeutics, Inc.
DispositionDirectStock Option (right to buy)
15.3K shares- - Aug 7, 2026OKUR
OnKure Therapeutics, Inc.
AwardDirectStock Option (right to buy)
300K shares- - Jun 30, 2026QTTB
Q32 Bio Inc.
ExerciseDirect53.5K shares at avg. $2.80$150K - Jun 12, 2026QTTB
Q32 Bio Inc.
AwardDirectStock Option (Right to Buy)
10.8K shares- - Jun 12, 2026QTTB
Q32 Bio Inc.
AwardDirectStock Option (Right to Buy)
9.8K shares- - Dec 31, 2025OKUR
OnKure Therapeutics, Inc.
AwardDirect5.3K shares- - Oct 23, 2025QTTB
Q32 Bio Inc.
AwardDirectStock Option (Right to Buy)
53.5K shares-
| Type | Shares | Price | Ownership | |||
|---|---|---|---|---|---|---|
| Sep 2, 2026 |  ADXN Addex Therapeutics Ltd. | Disposition | 219,561 | - | $0 | Direct |
| Sep 2, 2026 | ADXN Addex Therapeutics Ltd. | Award | 219,561 | - | $0 | Direct |
| Aug 7, 2026 |  OKUR OnKure Therapeutics, Inc. | Award Stock Option (right to buy) | 15,300 | - | - | Direct |
| Aug 7, 2026 | OKUR OnKure Therapeutics, Inc. | Disposition Stock Option (right to buy) | 15,300 | - | - | Direct |
| Aug 7, 2026 | OKUR OnKure Therapeutics, Inc. | Award Stock Option (right to buy) | 300,000 | - | - | Direct |
| Jun 30, 2026 |  QTTB Q32 Bio Inc. | Exercise | 53,521 | $2.80 | $149,859 | Direct |
| Jun 12, 2026 | QTTB Q32 Bio Inc. | Award Stock Option (Right to Buy) | 10,826 | - | - | Direct |
| Jun 12, 2026 | QTTB Q32 Bio Inc. | Award Stock Option (Right to Buy) | 9,810 | - | - | Direct |
| Dec 31, 2025 | OKUR OnKure Therapeutics, Inc. | Award | 5,258 | - | $0 | Direct |
| Oct 23, 2025 | QTTB Q32 Bio Inc. | Award Stock Option (Right to Buy) | 53,521 | - | - | Direct |
1-10 of 23 transactions