HighVista Strategies LLC
CIK: 1335325
Holdings (147)
Q2 2026 13F, quarter ended Jun 30, 2026, filed Aug 14, 2026
- DBC
INVESCO DB COMMDY INDX TRCK
$28.19M
1.06M sh6.43%+0.0% - ABVX
ABIVAX SA
$15.06M
113,031 sh3.43%-0.2% - RVMD
REVOLUTION MEDICINES INC
$12.54M
66,983 sh2.86%-3.4% - DFTX
DEFINIUM THERAPEUTICS INC
$11.43M
242,884 sh2.60%+30.7% - IMVT
IMMUNOVANT INC
$10.71M
277,873 sh2.44%+23.4% - PRAX
PRAXIS PRECISION MEDICINES I
$10.11M
30,210 sh2.31%+14.8% - RLAY
RELAY THERAPEUTICS INC
$9.47M
506,235 sh2.16%+20.0% - ALKS
ALKERMES PLC
$9.39M
179,256 sh2.14%+144.9% - PCVX
VAXCYTE INC
$8.7M
149,739 sh1.98%+20.1% - TNGX
TANGO THERAPEUTICS INC
$8.13M
260,070 sh1.85%+149.6% - LQDA
LIQUIDIA CORPORATION
$7.81M
97,896 sh1.78%-1.9% - COGT
COGENT BIOSCIENCES INC
$7.31M
188,780 sh1.67%-4.2% - GPCR
STRUCTURE THERAPEUTICS INC
$7.02M
130,784 sh1.60%+5.5% - ELVN
ENLIVEN THERAPEUTICS INC
$7M
137,866 sh1.60%+88.6% - AMLX
AMYLYX PHARMACEUTICALS INC
$6.93M
386,080 sh1.58%+9.7% - SYRE
SPYRE THERAPEUTICS INC
$6.91M
77,807 sh1.57%-46.8% - LBRX
LB PHARMACEUTICALS INC
$6.86M
211,511 sh1.57%+21.8% - CYTK
CYTOKINETICS INC
$6.65M
78,003 sh1.52%+33.0% - CCCC
C4 THERAPEUTICS INC
$6.3M
1.35M sh1.44%New - TYRA
TYRA BIOSCIENCES INC
$5.9M
184,774 sh1.35%+40.7% - ALMS
ALUMIS INC
$5.63M
199,968 sh1.28%+77.1% - PHVS
PHARVARIS N V
$5.55M
160,494 sh1.27%+64.0% - TARS
TARSUS PHARMACEUTICALS INC
$5.48M
87,060 sh1.25%+65.9% - CMPS
COMPASS PATHWAYS PLC
$5.25M
371,120 sh1.20%+1.9% - DNTH
DIANTHUS THERAPEUTICS INC
$4.98M
51,125 sh1.14%+43.7% - NRIX
NURIX THERAPEUTICS INC
$4.94M
203,739 sh1.13%-10.1% - AXSM
AXSOME THERAPEUTICS INC.
$4.94M
20,183 sh1.13%-1.2% - TVTX
TRAVERE THERAPEUTICS INC
$4.9M
86,233 sh1.12%+137.4% - VERA
VERA THERAPEUTICS INC
$4.54M
105,907 sh1.04%+53.0% - NVDA
NVIDIA CORPORATION
$4.36M
21,792 sh0.99%-2.8% - GHRS
GH RESEARCH PLC
$4.27M
158,770 sh0.97%-25.5% - PALI
PALISADE BIO INC
$4.24M
2.03M sh0.97%+0.6% - ARGX
ARGENX SE
$4.23M
4,561 sh0.96%-7.3% - MAZE
MAZE THERAPEUTICS INC
$4.08M
136,572 sh0.93%+36.8% - OCUL
OCULAR THERAPEUTIX INC
$4.01M
408,534 sh0.91%-7.5% - ORKA
ORUKA THERAPEUTICS INC
$3.99M
41,902 sh0.91%-46.9% - DYN
DYNE THERAPEUTICS INC
$3.82M
171,961 sh0.87%-6.0% - EWTX
EDGEWISE THERAPEUTICS INC
$3.7M
90,996 sh0.84%-1.0% - MLTX
MOONLAKE IMMUNOTHERAPEUTICS
$3.66M
187,946 sh0.83%-3.1% - INSM
INSMED INC
$3.33M
31,256 sh0.76%+28.5% - CLDX
CELLDEX THERAPEUTICS INC NEW
$3.24M
86,964 sh0.74%-2.7% - AMZN
AMAZON COM INC
$3.19M
13,397 sh0.73%-40.2% - IVA
INVENTIVA SA
$3.14M
831,442 sh0.72%+35.0% - TLN
TALEN ENERGY CORP
$3.13M
8,148 sh0.71%+161.3% - RLMD
RELMADA THERAPEUTICS INC
$3.08M
445,799 sh0.70%New - PTGX
PROTAGONIST THERAPEUTICS INC
$3M
24,460 sh0.68%-27.7% - ERAS
ERASCA INC
$2.94M
160,328 sh0.67%-11.4% - VRDN
VIRIDIAN THERAPEUTICS INC
$2.94M
159,885 sh0.67%+19.1% - HPE
HEWLETT PACKARD ENTERPRISE C
$2.67M
59,081 sh0.61%-34.3% - MLYS
MINERALYS THERAPEUTICS INC
$2.32M
86,085 sh0.53%+84.0%
| Security | Shares | Value | Change | Weight | Period |
|---|---|---|---|---|---|
 DBC INVESCO DB COMMDY INDX TRCK | 1.06M | $28.19M | +0.0% | 6.43% | Q2 2026 |
 ABVX ABIVAX SA | 113,031 | $15.06M | -0.2% | 3.43% | Q2 2026 |
 RVMD REVOLUTION MEDICINES INC | 66,983 | $12.54M | -3.4% | 2.86% | Q2 2026 |
 DFTX DEFINIUM THERAPEUTICS INC | 242,884 | $11.43M | +30.7% | 2.60% | Q2 2026 |
 IMVT IMMUNOVANT INC | 277,873 | $10.71M | +23.4% | 2.44% | Q2 2026 |
 PRAX PRAXIS PRECISION MEDICINES I | 30,210 | $10.11M | +14.8% | 2.31% | Q2 2026 |
 RLAY RELAY THERAPEUTICS INC | 506,235 | $9.47M | +20.0% | 2.16% | Q2 2026 |
 ALKS ALKERMES PLC | 179,256 | $9.39M | +144.9% | 2.14% | Q2 2026 |
 PCVX VAXCYTE INC | 149,739 | $8.7M | +20.1% | 1.98% | Q2 2026 |
 TNGX TANGO THERAPEUTICS INC | 260,070 | $8.13M | +149.6% | 1.85% | Q2 2026 |
 LQDA LIQUIDIA CORPORATION | 97,896 | $7.81M | -1.9% | 1.78% | Q2 2026 |
 COGT COGENT BIOSCIENCES INC | 188,780 | $7.31M | -4.2% | 1.67% | Q2 2026 |
 GPCR STRUCTURE THERAPEUTICS INC | 130,784 | $7.02M | +5.5% | 1.60% | Q2 2026 |
 ELVN ENLIVEN THERAPEUTICS INC | 137,866 | $7M | +88.6% | 1.60% | Q2 2026 |
 AMLX AMYLYX PHARMACEUTICALS INC | 386,080 | $6.93M | +9.7% | 1.58% | Q2 2026 |
 SYRE SPYRE THERAPEUTICS INC | 77,807 | $6.91M | -46.8% | 1.57% | Q2 2026 |
 LBRX LB PHARMACEUTICALS INC | 211,511 | $6.86M | +21.8% | 1.57% | Q2 2026 |
 CYTK CYTOKINETICS INC | 78,003 | $6.65M | +33.0% | 1.52% | Q2 2026 |
 CCCC C4 THERAPEUTICS INC | 1.35M | $6.3M | New | 1.44% | Q2 2026 |
 TYRA TYRA BIOSCIENCES INC | 184,774 | $5.9M | +40.7% | 1.35% | Q2 2026 |
 ALMS ALUMIS INC | 199,968 | $5.63M | +77.1% | 1.28% | Q2 2026 |
 PHVS PHARVARIS N V | 160,494 | $5.55M | +64.0% | 1.27% | Q2 2026 |
 TARS TARSUS PHARMACEUTICALS INC | 87,060 | $5.48M | +65.9% | 1.25% | Q2 2026 |
 CMPS COMPASS PATHWAYS PLC | 371,120 | $5.25M | +1.9% | 1.20% | Q2 2026 |
 DNTH DIANTHUS THERAPEUTICS INC | 51,125 | $4.98M | +43.7% | 1.14% | Q2 2026 |
 NRIX NURIX THERAPEUTICS INC | 203,739 | $4.94M | -10.1% | 1.13% | Q2 2026 |
 AXSM AXSOME THERAPEUTICS INC. | 20,183 | $4.94M | -1.2% | 1.13% | Q2 2026 |
 TVTX TRAVERE THERAPEUTICS INC | 86,233 | $4.9M | +137.4% | 1.12% | Q2 2026 |
 VERA VERA THERAPEUTICS INC | 105,907 | $4.54M | +53.0% | 1.04% | Q2 2026 |
 NVDA NVIDIA CORPORATION | 21,792 | $4.36M | -2.8% | 0.99% | Q2 2026 |
 GHRS GH RESEARCH PLC | 158,770 | $4.27M | -25.5% | 0.97% | Q2 2026 |
 PALI PALISADE BIO INC | 2.03M | $4.24M | +0.6% | 0.97% | Q2 2026 |
 ARGX ARGENX SE | 4,561 | $4.23M | -7.3% | 0.96% | Q2 2026 |
 MAZE MAZE THERAPEUTICS INC | 136,572 | $4.08M | +36.8% | 0.93% | Q2 2026 |
 OCUL OCULAR THERAPEUTIX INC | 408,534 | $4.01M | -7.5% | 0.91% | Q2 2026 |
 ORKA ORUKA THERAPEUTICS INC | 41,902 | $3.99M | -46.9% | 0.91% | Q2 2026 |
 DYN DYNE THERAPEUTICS INC | 171,961 | $3.82M | -6.0% | 0.87% | Q2 2026 |
 EWTX EDGEWISE THERAPEUTICS INC | 90,996 | $3.7M | -1.0% | 0.84% | Q2 2026 |
 MLTX MOONLAKE IMMUNOTHERAPEUTICS | 187,946 | $3.66M | -3.1% | 0.83% | Q2 2026 |
 INSM INSMED INC | 31,256 | $3.33M | +28.5% | 0.76% | Q2 2026 |
 CLDX CELLDEX THERAPEUTICS INC NEW | 86,964 | $3.24M | -2.7% | 0.74% | Q2 2026 |
 AMZN AMAZON COM INC | 13,397 | $3.19M | -40.2% | 0.73% | Q2 2026 |
 IVA INVENTIVA SA | 831,442 | $3.14M | +35.0% | 0.72% | Q2 2026 |
 TLN TALEN ENERGY CORP | 8,148 | $3.13M | +161.3% | 0.71% | Q2 2026 |
 RLMD RELMADA THERAPEUTICS INC | 445,799 | $3.08M | New | 0.70% | Q2 2026 |
 PTGX PROTAGONIST THERAPEUTICS INC | 24,460 | $3M | -27.7% | 0.68% | Q2 2026 |
 ERAS ERASCA INC | 160,328 | $2.94M | -11.4% | 0.67% | Q2 2026 |
 VRDN VIRIDIAN THERAPEUTICS INC | 159,885 | $2.94M | +19.1% | 0.67% | Q2 2026 |
 HPE HEWLETT PACKARD ENTERPRISE C | 59,081 | $2.67M | -34.3% | 0.61% | Q2 2026 |
 MLYS MINERALYS THERAPEUTICS INC | 86,085 | $2.32M | +84.0% | 0.53% | Q2 2026 |
1-50 of 147 holdings
Sector Allocation
SEC Filings
| Form | Description | Filed |
|---|---|---|
About HighVista Strategies LLC
HighVista Strategies LLC is an Investment Adviser that reports its US-listed stock and option positions to the SEC on Form 13F (CIK 1335325). Signal8 holds 20 13F filings from it. Its SEC filings list Delaware as its state of incorporation.
Its most recent 13F holdings report covers Q2 2026 (the quarter ended Jun 30, 2026) and was filed on Aug 14, 2026. That report lists 147 securities, not counting options, down from 156 in Q1 2026.
Its five largest reported positions, in order, are INVESCO DB COMMDY INDX TRCK (DBC), ABIVAX SA (ABVX), REVOLUTION MEDICINES INC (RVMD), DEFINIUM THERAPEUTICS INC (DFTX) and IMMUNOVANT INC (IMVT). The next five are PRAXIS PRECISION MEDICINES I (PRAX), RELAY THERAPEUTICS INC (RLAY), ALKERMES PLC (ALKS), VAXCYTE INC (PCVX) and TANGO THERAPEUTICS INC (TNGX).
Recent 13F filings by HighVista Strategies LLC
- Q2 2026: 13F-HR filed Aug 14, 2026, listing 147 securities.
- Q1 2026: 13F-HR filed May 15, 2026, listing 156 securities.
- Q4 2025: 13F-HR filed Feb 17, 2026, listing 145 securities.
- Q3 2025: 13F-HR filed Nov 14, 2025, listing 148 securities.
- Q2 2025: 13F-HR filed Aug 14, 2025, listing 146 securities.
- Q1 2025: 13F-HR filed May 15, 2025, listing 148 securities.