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Tovecimig Demonstrates Statistically Significant Benefit in COMPANION-002 Randomized Phase 2/3 Study in Patients with Biliary Tract Cancer

$CMPXPress releaseApr 27, 2026, 7:30 AM ETRead the release

Compass Therapeutics reported positive topline results from the COMPANION-002 Phase 2/3 study of tovecimig in biliary tract cancer, meeting the primary ORR endpoint and key secondary PFS endpoint. Median progression-free survival was 4.7 months for the combination versus 2.6 months for paclitaxel alone, representing a 56% reduction in the risk of disease progression with a hazard ratio of 0.44.

Key figures

Drug Name
tovecimig
Phase Of Trial
Phase 2/3
Pfs months
4.7
Orr percent
17.1
P value pfs
<0.0001
Hazard ratio
0.44
Pfs control months
2.6
Orr control percent
5.3

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