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Lilly's EloraTZP (combination of eloralintide and tirzepatide) delivered greater weight loss and A1C reduction vs. tirzepatide 15 mg in adults with obesity and type 2 diabetes

$LLYPress releaseSep 30, 2026, 10:15 AM ETRead the release

Eli Lilly announced positive 48-week Phase 2b results for EloraTZP, its combination of the amylin agonist eloralintide and tirzepatide, in 367 adults with obesity or overweight and type 2 diabetes. The best-performing combination produced average weight loss of 54.1 lbs (23.3%) and A1C reduction of 2.9%, versus 34.4 lbs (14.8%) and 2.4% for tirzepatide 15 mg alone.

Key figures

Drug Name
EloraTZP (eloralintide + tirzepatide)
Phase Of Trial
Phase 2b
Participants
367
Weight loss best
54.1 lbs (23.3%)
A1c reduction best
2.9%
Trial duration weeks
48
Weight loss tirzepatide 15mg
34.4 lbs (14.8%)
A1c reduction tirzepatide 15mg
2.4%

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