Skip to main content
Signal8

TwinStrand Biosciences Announces Second U.S. Patent Trial and Appeal Board Decision Upholding All Claims of TwinStrand’s ‘127 Patent

$GHPress releaseOct 15, 2026, 4:01 PM ETRead the release

The PTAB again rejected Guardant Health's challenge to TwinStrand's '127 patent, upholding all 30 challenged claims on remand from the Federal Circuit under a new legal framework. Guardant had already been found to willfully infringe this patent and the '631 patent in a November 2023 jury verdict, with final judgment entered in August 2026 awarding more than $245.2 million in damages, royalties and interest.

Key figures

Damages awarded
$245.2 million
Patents at issue
["U.S. Patent No. 10,760,127","U.S. Patent No. 10,287,631"]
Royalty end date
March 2033
Ongoing royalty rate
6%
Challenged claims rejected
30

AI analysis

Red flags3 · Pro

The rest of the AI analysis, red flags and sentiment are part of Signal8 Pro.

AI-generated analysis of a public disclosure. Not investment advice; verify against the original document.

    GH: TwinStrand Biosciences Announces Second U.S. Patent Trial and Appeal Board Decision Upholding All Claims of TwinStrand’s ‘127 Patent — AI Analysis | Signal8