Genprex Highlights New Preclinical Data Identifying Role of TUSC2, the Gene Used in REQORSA®, in Maintaining Cellular Function During Brain Aging

Genprex highlighted a new peer-reviewed study, published in Mechanisms of Ageing and Development by Meharry Medical College researchers, identifying a role for the TUSC2 tumor suppressor gene — the gene used in its REQORSA cancer therapy — in maintaining cellular function during brain aging. In a mouse knockout model, TUSC2 loss disrupted mitochondrial function, protein homeostasis, and synaptic pathways in the hippocampus, with effects more pronounced in males. Human datasets showed TUSC2 expression declining with age in 11 of 13 brain regions and further in Alzheimer's disease data.

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