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Akeso Announces Summit Therapeutics and ECOG-ACRIN Cancer Research Group Enter into Phase II/III Clinical Trial Collaboration to Evaluate Ivonescimab in First-Line Biliary Tract Cancer

$SMMTPress releaseOct 21, 2026, 8:43 AM ETRead the release

Summit Therapeutics and the ECOG-ACRIN Cancer Research Group entered a clinical trial collaboration to run EA2251, a registration-enabling Phase II/III study of ivonescimab plus chemotherapy in first-line advanced biliary tract cancer. The study is the 7th international registrational trial for ivonescimab and the second Phase III registrational study in BTC; US site activations are expected to begin in Q4 2026.

Key figures

Drug Name
ivonescimab
Phase Of Trial
Phase II/III
Study
EA2251
Nct id
NCT07765433
Site activation timing
Q4 2026
Registrational trials count
7

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