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REG-Genmab and Incyte Announce Clinical Trial Collaboration in Metastatic Colorectal Cancer

$GMABPress releaseOct 24, 2026, 7:00 AM ETRead the release

Genmab and Incyte announced a clinical trial collaboration to evaluate petosemtamab plus Incyte's KRAS G12D inhibitor INCB161734 and standard-of-care chemotherapy in first-line KRAS G12D-mutated metastatic colorectal cancer. Genmab will conduct the Phase 1/2 study, while Incyte will co-fund the trial and supply INCB161734, sharing development cost and risk.

Key figures

Drug Name
petosemtamab (GEN1158)
Phase Of Trial
Phase 1/2
Indication
first-line KRAS G12D-mutated metastatic colorectal cancer
Combination agent
INCB161734 (KRAS G12D inhibitor)

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