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Atrium Therapeutics Doses First Patient in Corventis™, the First Interventional Clinical Trial for People Living with PRKAG2 Syndrome

$RNAPress releaseOct 27, 2026, 6:30 AM ETRead the release

Atrium Therapeutics dosed the first patient in Corventis, a global Phase 1/2 trial of ATR 1072, its lead siRNA antibody-oligonucleotide conjugate targeting PRKAG2 syndrome. The trial will enroll approximately 37 participants, with Part A ascending-dose cohorts for safety and a Part B single-arm expansion at the recommended Phase 2 dose; initial proof-of-concept data are expected in the second half of 2027.

Key figures

Drug Name
ATR 1072
Phase Of Trial
Phase 1/2
Planned enrollment
approximately 37 participants
Us prevalence prkag2
1,000 - 2,000 people
Proof of concept data timing
second half of 2027

AI analysis

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    RNA: Atrium Therapeutics Doses First Patient in Corventis™, the First Interventional Clinical Trial for People Living with PRKAG2 Syndrome — AI Analysis | Signal8