Emory Researchers Identify Blood Protein Signature That Detects ALS With 98% Accuracy Using Alamar Technology
Emory University researchers used Alamar Biosciences' NULISA technology to identify a 10-protein blood signature that detected ALS with 98.3% balanced accuracy (AUC 0.992) in an independent validation cohort, published in Nature Communications. The signature outperformed neurofilament light chain alone, the established ALS blood biomarker, which achieved 89.9% accuracy, and correctly identified patients missed by NFL including those with little disability.
Key figures
- Auc
- 0.992
- Signature size
- 10-protein blood signature
- Discovery cohort
- 632 ALS patients and 160 healthy controls
- Balanced accuracy
- 98.3%
- Proteins measured
- more than 300
- Validation cohort
- 144 ALS patients and 37 controls
- Nfl alone accuracy
- 89.9%
AI analysis
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