Acumen Pharmaceuticals Announces Nomination of Two Enhanced Brain Delivery™ (EBD™) Development Candidates for the Treatment of Alzheimer’s Disease
Acumen Pharmaceuticals nominated two development candidates, ACU301 and ACU401, in its Enhanced Brain Delivery program for Alzheimer’s disease, exercising an option under its license with JCR Pharmaceuticals. Preclinical studies demonstrated antibody levels 14-40x higher in non-human primates compared to native antibodies, with no adverse events observed and favorable stability supporting subcutaneous dosing.
Key figures
- Phase 2 enrollment
- 542
- Brain penetration multiplier
- 14-40x
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