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Verastem Oncology Doses First Patient in TARGET-D 201 Phase 2 Registration-Directed Trial of VS-7375 Oral KRAS G12D (ON/OFF) Inhibitor for KRAS G12D-Mutated Metastatic Pancreatic Cancer

$VSTMPress releaseJun 16, 2026, 4:01 PM ETRead the release

Verastem Oncology dosed the first patient in the TARGET-D 201 Phase 2 registration-directed trial of VS-7375 for KRAS G12D-mutated metastatic pancreatic cancer. The trial evaluates VS-7375 at 900 mg daily as monotherapy and in combination with cetuximab for second-line treatment, with an additional cohort assessing the combination in the frontline setting.

Key figures

Drug Name
VS-7375
Phase Of Trial
Phase 2
Dose mg
900
Metastatic pancreatic dx annual us
30000
Kras g12d prevalence pancreatic pct
40
Metastatic pancreatic dx annual global
240000

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