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Pfizer Announces Topline Phase 3 Results for Sigvotatug Vedotin in Previously Treated Metastatic Non-Squamous Non-Small Cell Lung Cancer

$PFEPress releaseJun 22, 2026, 4:30 PM ETRead the release

Pfizer's Phase 3 SigVie-002 study of sigvotatug vedotin in previously treated non-squamous NSCLC did not meet its primary endpoint of overall survival compared to docetaxel. Despite the overall miss, the company reported a stronger trend in overall survival and progression-free survival for the subset of patients who received only one prior line of therapy.

Key figures

Drug Name
sigvotatug vedotin
Phase Of Trial
Phase 3
Participants enrolled
703
Oncology breakthroughs goal by 2030
8

AI analysis

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    PFE: Pfizer Announces Topline Phase 3 Results for Sigvotatug Vedotin in Previously Treated Metastatic Non-Squamous Non-Small Cell Lung Cancer — AI Analysis | Signal8