Skip to main content
Signal8

Zentalis Pharmaceuticals Announces First Patient Dosed in ASPENOVA Phase 3 Trial of Azenosertib in Patients with Cyclin E1-Positive Platinum-Resistant Ovarian Cancer

$ZNTLPress releaseMay 5, 2026, 8:00 AM ETRead the release

Zentalis dosed the first patient in the Phase 3 ASPENOVA trial evaluating azenosertib in Cyclin E1-positive platinum-resistant ovarian cancer. The confirmatory study is designed to support full approval and will enroll approximately 420 patients to compare the WEE1 inhibitor against standard-of-care chemotherapy.

Key figures

Drug Name
azenosertib
Phase Of Trial
Phase 3
Azenosertib dose
400mg QD 5:2
Aspnova enrollment
approximately 420
Denali readout timing
year-end 2026

AI analysis

The rest of the AI analysis, red flags and sentiment are part of Signal8 Pro.

AI-generated analysis of a public disclosure. Not investment advice; verify against the original document.