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Vaccinex to Report New Biomarker Data and Plans for Phase 2B Clinical Trial of Pepinemab in AD at the Alzheimer’s Association International Conference in London on July 13, 2026

$VCNXPress releaseJul 8, 2026, 8:30 AM ETRead the release

Vaccinex announced it will present new biomarker data from its Phase 1b/2 SIGNAL-AD trial and outline plans for an enlarged randomized Phase 2B SIGNAL-AD2 study of pepinemab for early Alzheimer's disease at the AAIC conference in London. The presentation will highlight evidence that pepinemab regulates glial biomarkers associated with synaptic loss and cognitive decline, supporting the hypothesis that blocking SEMA4D protects astrocyte function.

Key figures

Drug Name
Pepinemab
Phase Of Trial
Phase 2B
Trial name 1
SIGNAL-AD
Trial name 2
SIGNAL-AD2
Conference date
July 13, 2026

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