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Spyre Therapeutics Announces Launch of SPY772 Program and Initiation of Phase 2 SKYLIGHT Trial in Hidradenitis Suppurativa

$SYREPress releaseAug 10, 2026, 8:00 AM ETRead the release

Spyre Therapeutics launched the SPY772 program, a long-acting coformulation of anti-TL1A and anti-IL-17A/F antibodies, and initiated the Phase 2 SKYLIGHT trial in Hidradenitis Suppurativa. The randomized study will enroll approximately 150 adults to evaluate the efficacy of adding SPY072 to background bimekizumab therapy, with topline HiSCR75 data expected in late 2027 or early 2028.

Key figures

Phase Of Trial
Phase 2
Primary endpoint
HiSCR75
Patients enrolled
150
Data readout timing
late 2027 or early 2028

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