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Sentynl Therapeutics and Mereo BioPharma Announce Option and License Agreement for alvelestat in Alpha-1 Antitrypsin Deficiency-Associated Lung Disease (AATD-LD)

$MREOPress releaseAug 11, 2026, 8:00 AM ETRead the release

Mereo BioPharma entered into an option and license agreement with Sentynl Therapeutics for the U.S. commercial and global manufacturing rights to alvelestat for AATD-LD. Sentynl will fund the Phase 3 development program, and Mereo is eligible to receive up to $40 million in upfront and R&D payments upon option exercise, in addition to double-digit royalties on U.S. sales.

Key figures

Drug Name
alvelestat
Deal Value Usd
$40 million
Phase Of Trial
Phase 3
Prevalence us
50,000-80,000

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