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Rigel Announces Availability of VEPPANU™ (vepdegestrant) for Patients with ER+/HER2-, ESR1-Mutated Advanced or Metastatic Breast Cancer

$RIGLPress releaseAug 13, 2026, 8:05 AM ETRead the release

Rigel Pharmaceuticals announced that VEPPANU (vepdegestrant), the first and only FDA-approved PROTAC, is now available by prescription in the U.S. for adults with ER+/HER2-, ESR1-mutated advanced or metastatic breast cancer. The drug is priced at $29,400 per 30-day supply and is immediately available through specialty distributors and pharmacies, with patient support programs offered via RIGEL ONECARE.

Key figures

Drug Name
VEPPANU (vepdegestrant)
Dosage
200 mg orally once daily
Price per 30 days
$29,400

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