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The Lancet Neurology Publishes Data From Alkermes’ Positive Vibrance-1 Phase 2 Study of Alixorexton in Adults With Narcolepsy Type 1

$ALKSPress releaseAug 24, 2026, 6:30 PM ETRead the release

The Lancet Neurology published positive Phase 2 data from the Vibrance-1 study of Alixorexton for narcolepsy type 1, demonstrating statistically significant improvements in wakefulness and sleepiness. The study of 92 adults showed that all tested doses (4 mg, 6 mg, 8 mg) achieved normative ranges on key sleep scales, with the treatment generally well tolerated and no serious adverse events reported.

Key figures

Drug Name
Alixorexton
Phase Of Trial
Phase 2
Doses tested
4 mg, 6 mg, 8 mg
Patient count
92
Ess normative range score
≤10
Mwt normative range minutes
≥20 minutes

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