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OPKO Health’s ModeX Therapeutics Begins Clinical Trial of Tetraspecific Antibody for Treatment of B-cell Lymphomas

$OPKPress releaseApr 22, 2026, 8:00 AM ETRead the release

ModeX Therapeutics, an OPKO Health company, announced the dosing of patients in a Phase 1 trial for MDX2003, a first-in-class tetraspecific antibody targeting B-cell lymphomas. The MDX-2003-101 study is designed to evaluate safety, tolerability, and immune activity of the drug, which targets CD19, CD20, CD3, and CD28 to optimize T-cell killing.

Key figures

Drug Name
MDX2003
Phase Of Trial
Phase 1
Clinical trial id
NCT07249905

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