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Spyre Therapeutics, Inc. (SYRE) Form 424B5 — Oct 5, 2026

$SYREForm 424B5Filed Oct 5, 2026, 4:10 PM ET0001628280-26-064924Original filing

Spyre Therapeutics filed a preliminary prospectus supplement for a marketed offering of common stock off its S-3 shelf, with Jefferies, TD Cowen, Leerink Partners, and Stifel as joint book-runners and LifeSci Capital as passive bookrunner. Pricing, share count, and expected proceeds were not yet disclosed as of the filing date. The last reported sale price was $93.19 on October 2, 2026, and the company had approximately $1.1 billion in cash and investments as of June 30, 2026, expected to fund operations into the second half of 2029.

Key figures

Cash Position
$1.1 billion (cash, cash equivalents and marketable securities as of June 30, 2026)
Shares Outstanding
101905933
Cash runway
into the second half of 2029
Last sale price date
2026-10-02
Atm capacity remaining
approximately $451.6 million under Sales Agreement
Last reported sale price
93.19
Net tangible book value per share
12.5
Atm shares sold since june 30 2026
527502
Pro forma net tangible book value per share
10.81

AI analysis

Red flags3 · Pro

The rest of the AI analysis, red flags and sentiment are part of Signal8 Pro.

AI-generated analysis of a public disclosure. Not investment advice; verify against the original document.

    Spyre Therapeutics, Inc. (SYRE) Form 424B5 — Oct 5, 2026: AI Analysis | Signal8