Aardvark Therapeutics, Inc. (AARD)
Aardvark Therapeutics, Inc. is a biopharmaceutical firm in its clinical development phase, concentrating on developing small-molecule treatments. These therapies are designed to stimulate the body's natural regulatory systems (innate homeostatic pathways) to combat metabolic disorders. The company's primary experimental drug, ARD-101, is an orally administered, gut-specific small molecule. It functions as an agonist, targeting particular bitter taste receptors found within the gut lumen. ARD-101 is currently undergoing a Phase III clinical trial for managing excessive hunger (hyperphagia) associated with Prader-Willi Syndrome. Additionally, it is in a Phase II trial for addressing hyperphagia linked to acquired hypothalamic obesity, often a result of craniopharyngioma treatments like surgery or radiation therapy. Aardvark Therapeutics is also advancing ARD-201, which is currently in Phase I clinical trials for the treatment of obesity. Established in 2017, the company is based in San Diego, California.
Sector: Pharmaceutical Preparations
Industry: Biotechnology
Aardvark Therapeutics, Inc. Common Stock
Trials need funding. See this company's dilution risk and cash position.
- Phase 3Terminated
ARD-101 for Treatment of PWS: The Hunger Elimination or Reduction Objective Trial
Placebo, ARD-101
Hyperphagia, Prader-Willi Syndrome
NCT06828861Enrollment68StartDec 2024Primary CompletionMay 2026CompletionMay 2026 - Phase 3Terminated
The Hunger Elimination or Reduction Objective (HERO ) Open -Label Extension (OLE) Trial
ARD-101
Hyperphagia, Prader-Willi Syndrome +1
NCT07197034Enrollment19StartJul 2024Primary CompletionApr 2026CompletionApr 2026 - Phase 2Completed
Study to Evaluate ARD-101 in Adults With Obesity
ARD-101, Placebo
Obesity
NCT05121441Enrollment20StartNov 2021Primary CompletionNov 2022CompletionNov 2022 - Phase 2Completed
A Study of Oral ARD-101 in Patients With Prader-Willi Syndrome
ARD-101
Prader-Willi Syndrome
NCT05153434Enrollment19StartMay 2022Primary CompletionSep 2024CompletionSep 2024 - Phase 2Completed
Study to Evaluate ARD-101 in Adults Receiving Bariatric Surgery
ARD-101
Bariatric Surgery, Obesity +1
NCT05215847Enrollment12StartMar 2022Primary CompletionFeb 2023CompletionFeb 2023 - Phase 2Completed
A Study to Evaluate ARD-501 in Patients With Autism Spectrum Disorder
Low Dose ARD-501, High Dose ARD-501
Autism Spectrum Disorder
NCT06126653Enrollment5StartAug 2024Primary CompletionJan 2025CompletionJan 2025 - ObservationalCompleted
Home Usability of a Nasal Lavage System in Children
Use of an automatic nasal irrigator/aspirator
Nasal Congestion, Respiratory Tract Infection +2
NCT01129765Enrollment30StartJul 2009Primary CompletionAug 2009CompletionAug 2009
| Drug / Therapy | Link | ||
|---|---|---|---|
| Phase 3 | Terminated | Placebo, ARD-101 | NCT06828861 |
| Phase 3 | Terminated | ARD-101 | NCT07197034 |
| Phase 2 | Completed | ARD-101, Placebo | NCT05121441 |
| Phase 2 | Completed | ARD-101 | NCT05153434 |
| Phase 2 | Completed | ARD-101 | NCT05215847 |
| Phase 2 | Completed | Low Dose ARD-501, High Dose ARD-501 | NCT06126653 |
| Observational | Completed | Use of an automatic nasal irrigator/aspirator | NCT01129765 |