AC Immune SA (ACIU)
AC Immune S.A. is a biotech firm operating at the clinical stage, dedicated to pioneering, formulating, and advancing therapeutic agents and diagnostic tools. Its core mission is addressing neurodegenerative conditions rooted in protein misfolding, both preventatively and therapeutically. Leveraging its proprietary SupraAntigen and Morphomer platforms, the company engineers a range of vaccines, antibodies, and small molecules specifically designed to engage with aberrantly folded proteins implicated across various neurodegenerative disorders. Its pipeline features Crenezumab, a humanized, conformation-specific monoclonal antibody currently undergoing a Phase II clinical prevention trial for Alzheimer's disease (AD). Additionally, AC Immune is advancing ACI-24, an anti-Abeta vaccine candidate, which is in Phase II clinical evaluation for AD and has successfully completed a Phase Ib study for Down syndrome. Other key candidates include ACI-35, an anti-Tau vaccine candidate that has finished Phase Ib clinical assessment, and a Tau-positron emission tomography (PET) imaging tracer, also in Phase II development. Furthermore, the company is engaged in the research and development of small molecule inhibitors to prevent Tau aggregation, targeting AD and various NeuroOrphan indications. Early-stage efforts include discovery and preclinical programs for a spectrum of neurodegenerative diseases, encompassing diagnostic agents aimed at TDP-43, alpha-synuclein, and NLRP3. The company maintains strategic partnerships and licensing agreements with key industry players such as Genentech, Inc., Biogen International GmbH, Janssen Pharmaceuticals, Inc., Life Molecular Imaging SA, Eli Lilly and Company, and WuXi Biologics. Founded in 2003, AC Immune S.A. is headquartered in Lausanne, Switzerland.
Sector: Pharmaceutical Preparations
Industry: Biotechnology
AC Immune S.A.
NASDAQ:ACIUHealthcare · Biotechnology
-4.55%$2.31
AH Close$2.31+0.00%vs close
AH Close$2.31+0.00%vs close
Mkt Cap$229.68M
Float74.67M
O/S99.43M
Inst Own24.6%
SI4.4%
Dilution
Delisting Issues Timeline
Financials Summary
Revenue$4.32M
Net Income-$85.27M
Total Assets$186.92M
Free Cash Flow-$81.11M
Debt & Equity
Debt 9%
Equity 91%
Total Debt$5.5M
Total Equity$54.39M
Shares Outstanding
Short Interest
Split History
No splits on record
Nothing in ACIU's public trading history: no forward or reverse split has affected the share count.
Balance Sheet Details
Assets$186.92M
Liabilities$132.53M
Accounts Receivable$1.62M
Accounts Payable$2.5M
Inventory$0
PP&E (Net)$7.91M
Goodwill$0
Intangible Assets$61.09M
Income Statement
| Period | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 | FY 2015 | FY 2014 | FY 2013 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Currency | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD |
| Period Ending | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | 2020-12-31 | 2019-12-31 | 2018-12-31 | 2017-12-31 | 2016-12-31 | 2015-12-31 | 2014-12-31 | 2013-12-31 |
| Revenue | $4.32M | $33.06M | $17.92M | $4.76M | $0 | $18.68M | $133.7M | $8.71M | $24.52M | $28.1M | $47.32M | $36.64M | $10.45M |
| YoY Growth | -86.9% | 84.5% | 276.1% | - | - | -86.0% | 1435.4% | -64.5% | -12.7% | -40.6% | 29.1% | 250.5% | - |
| Cost of Revenue | $0 | $75.74M | $66.1M | $0 | $0 | $72M | $61.04M | $53.59M | $39.54M | $31.2M | $20.64M | $19.51M | $20.8M |
| Gross Profit | $4.32M | -$42.68M | -$48.18M | $4.76M | $0 | -$53.33M | $72.65M | -$44.89M | -$15.02M | -$3.1M | $26.68M | $17.13M | -$10.34M |
| Gross Margin | 100.0% | -129.1% | -268.9% | 100.0% | - | -285.5% | 54.3% | -515.5% | -61.3% | -11.0% | 56.4% | 46.8% | -98.9% |
| Research and Development | $68.31M | $75.74M | $66.1M | $73.03M | $75.39M | $72M | $61.04M | $53.59M | $39.54M | $31.2M | $20.64M | $19.51M | $20.8M |
| Selling, General, and Administrative | $14.1M | $13.84M | $12.8M | $11.6M | $13.17M | $22.46M | $19.44M | $9.16M | $7.59M | $5.72M | $2.47M | $2.42M | $3.58M |
| Other | $5.26M | -$68.86M | -$62.17M | $5.89M | $7.08M | -$73.64M | -$61.73M | $5.93M | $4.67M | $3.83M | $1.67M | $1.74M | $0 |
| Total Operating Expenses | $87.68M | $20.72M | $16.73M | $90.52M | $95.64M | $20.82M | $18.75M | $68.68M | $51.8M | $40.76M | $24.77M | $23.67M | $3.34M |
| Operating Income (EBIT) | -$83.35M | -$63.4M | -$64.91M | -$85.76M | -$95.64M | -$74.15M | $53.91M | -$59.98M | -$27.28M | -$12.66M | $22.54M | $12.97M | -$13.92M |
| Operating Margin | -1927.3% | -191.8% | -362.3% | -1800.4% | - | -397.0% | 40.3% | -688.8% | -111.3% | -45.0% | 47.6% | 35.4% | -133.1% |
| Interest Expense | $231K | $161K | $213K | $430K | $703K | $223K | $2.33M | $404K | $178K | $310K | $31K | $5K | $0 |
| Interest Income | $2.26M | $3.87M | $1.26M | $84K | $7.85M | $94K | $367K | $154K | $399K | $52K | $67K | $27K | $70K |
| Other Income (Expense) | -$1.92M | $1.77M | -$725K | $130K | $7.28M | -$800K | $1.1M | -$1.7M | -$4.69M | $4.07M | $1.99M | $33K | $309K |
| Income Before Tax (EBT) | -$85.27M | -$61.63M | -$65.63M | -$85.63M | -$88.35M | -$74.95M | $55M | -$61.67M | -$31.97M | -$8.59M | $24.54M | $13M | -$13.61M |
| Income Tax Expense | $0 | $4K | $12K | $16K | $4K | $0 | $0 | $0 | $178K | $0 | $0 | $38K | $0 |
| Net Income | -$85.27M | -$61.63M | -$65.65M | -$85.64M | -$88.36M | -$74.95M | $55M | -$61.67M | -$31.97M | -$8.59M | $24.54M | $13M | -$13.61M |
| Net Income Margin | -1971.6% | -186.4% | -366.4% | -1798.0% | - | -401.3% | 41.1% | -708.2% | -130.4% | -30.6% | 51.9% | 35.5% | -130.2% |
| Supplementary Data | |||||||||||||
| EPS | -0.70 | -0.51 | -0.64 | -0.85 | -0.97 | -0.86 | 0.64 | -0.82 | -0.46 | -0.14 | 0.37 | 0.19 | -0.28 |
| Diluted EPS | -0.70 | -0.51 | -0.64 | -0.85 | -0.97 | -0.86 | 0.64 | -0.82 | -0.46 | -0.14 | 0.37 | 0.19 | -0.28 |
| Weighted Average OS | 100.75M | 99.69M | 84.69M | 83.55M | 74.95M | 71.90M | 70.60M | 61.84M | 57.08M | 50.10M | 55.40M | 55.40M | 40.59M |
| EBITDA | -$82.01M | -$58.85M | -$62.74M | -$82.34M | -$84.74M | -$71.77M | $55.96M | -$60.11M | -$27.28M | -$8.24M | $22.89M | $13.33M | -$13.56M |
| EBITDA Margin | -1896.2% | -178.0% | -350.2% | -1728.7% | - | -384.2% | 41.9% | -690.2% | -111.3% | -29.3% | 48.4% | 36.4% | -129.7% |
Balance Sheet
| Period | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 | FY 2015 | FY 2014 | FY 2013 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Currency | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD |
| Period Ending | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | 2020-12-31 | 2019-12-31 | 2018-12-31 | 2017-12-31 | 2016-12-31 | 2015-12-31 | 2014-12-31 | 2013-12-31 |
| Assets | |||||||||||||
| Current Assets | |||||||||||||
| Cash and Cash Equivalents | $32.47M | $43.91M | $95.01M | $38.23M | $99.52M | $194.75M | $234.32M | $189.39M | $150.55M | $184.24M | $92.62M | $4M | $13.62M |
| Short-Term Investments | $78.3M | $156.4M | $29.72M | $110.15M | $140.41M | $78.68M | $114.99M | $36.31M | $0 | $0 | $0 | $0 | $0 |
| Cash and Short-Term Investments | $110.65M | $200.31M | $124.73M | $148.38M | $239.93M | $273.43M | $349.31M | $225.7M | $150.55M | $184.24M | $92.62M | $4M | $13.62M |
| Accounts Receivable | $1.62M | $1.33M | $18.21M | $494K | $1.18M | $1.93M | $1.69M | $4.97M | $4.5M | $1.7M | $382K | $31.46M | $0 |
| Inventory | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | -$1.64M | $471K | $2.98M | $387K | $0 |
| Other Current Assets | $0 | $1.34M | $753K | $474K | $518K | $398K | $0 | $0 | $0 | $0 | $2.95M | $0 | $231K |
| Total Current Assets | $117.21M | $208.19M | $151.49M | $155.05M | $245.27M | $280.54M | $354.38M | $233.53M | $156.79M | $187.49M | $96.04M | $35.91M | $14.47M |
| Long-Term Assets | |||||||||||||
| Property, Plant & Equipment Net | $7.91M | $9.79M | $8.33M | $8.55M | $9.72M | $8.04M | $7.47M | $4.02M | $2.85M | $1.36M | $605K | $658K | $863K |
| Goodwill | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Intangible Assets | $61.09M | $61.03M | $61.03M | $61.03M | $61.03M | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Long-Term Investments | $708K | $0 | $437K | $0 | $0 | $0 | $368K | $368K | $153K | $104K | $103K | $0 | $0 |
| Deferred Tax Assets | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Other Long-Term Assets | $1K | $502K | $0 | $437K | $439K | $404K | $0 | $0 | $0 | $0 | $0 | $103K | $99K |
| Total Long-Term Assets | $69.71M | $71.32M | $69.79M | $70.02M | $71.18M | $8.44M | $7.84M | $4.39M | $3M | $1.46M | $708K | $761K | $962K |
| Other Assets | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Total Assets | $186.92M | $279.5M | $221.28M | $225.06M | $316.46M | $288.98M | $362.22M | $237.92M | $159.79M | $188.95M | $96.75M | $36.67M | $15.43M |
| Liabilities | |||||||||||||
| Current Liabilities | |||||||||||||
| Accounts Payable | $2.5M | $3.22M | $2.03M | $1.12M | $2.42M | $2.64M | $172K | $2.4M | $1.32M | $4.88M | $2.08M | $1.92M | $1.5M |
| Short-Term Debt | $0 | $0 | $0 | $0 | $0 | $0 | $789K | $402K | $0 | $0 | $0 | $0 | $0 |
| Current Income Tax Payable | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Current Unearned Revenue | $101.32M | $0 | $167K | $0 | $0 | $0 | $5.42M | $425K | $430K | $631K | $54K | $248K | $0 |
| Other Current Liabilities | $0 | $102.95M | $0 | $711K | $868K | $370K | $0 | $0 | $0 | $0 | $0 | $0 | $4.75M |
| Total Current Liabilities | $114.75M | $122.06M | $16.43M | $13.9M | $24.24M | $16.97M | $21.19M | $15.83M | $11.81M | $12.01M | $7.38M | $5.35M | $9.55M |
| Long-Term Liabilities | |||||||||||||
| Long-Term Debt | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $225K | $598K | $0 | $0 | $0 | $0 |
| Long-Term Unearned Revenue | $2.83M | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Long-Term Deferred Tax Liabilities | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Other Long-Term Liabilities | $10.48M | $16.22M | $6.98M | $3.89M | $8.59M | $9.03M | $9.06M | $6.86M | $5.48M | $4.6M | $3.37M | $2.92M | $0 |
| Total Long-Term Liabilities | $17.78M | $21.55M | $10.4M | $6.62M | $11.42M | $11.19M | $11.25M | $7.08M | $6.56M | $4.6M | $3.37M | $2.92M | $0 |
| Other Liabilities | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Total Liabilities | $132.53M | $143.61M | $26.84M | $20.51M | $35.66M | $28.16M | $32.45M | $22.92M | $18.37M | $16.61M | $10.76M | $8.27M | $9.55M |
| Stockholders' Equity | |||||||||||||
| Preferred Stock | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Common Stock | $2.73M | $2.69M | $2.53M | $2.18M | $2.17M | $1.86M | $1.74M | $1.64M | $1.39M | $1.37M | $1.12M | $1.03M | $983K |
| Retained Earnings | -$532.01M | -$445.73M | -$382.73M | -$319.57M | -$243.23M | -$160.81M | -$91.41M | -$147.52M | -$87.89M | -$56.79M | -$48.88M | -$73.18M | -$84.84M |
| Comprehensive Income & Other | $8K | -$6K | -$62K | $12K | $0 | $0 | $0 | -$4.29M | $217.09M | -$2.61M | -$2.27M | -$1.92M | $0 |
| Other Stockholders' Equity | $583.67M | $578.93M | $574.65M | $521.95M | $521.85M | $419.76M | $419.45M | $360.89M | $227.92M | $227.76M | $133.75M | $100.55M | $88.62M |
| Total Equity | $54.39M | $135.89M | $194.45M | $204.55M | $280.79M | $260.82M | $329.77M | $215M | $141.43M | $172.34M | $85.99M | $28.41M | $4.76M |
| Minority Interest | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Total Liabilities and Equity | $186.92M | $279.5M | $221.28M | $225.06M | $316.46M | $288.98M | $362.22M | $237.92M | $159.79M | $188.95M | $96.75M | $36.67M | $14.31M |
| Supplementary Data | |||||||||||||
| Total Debt | $5.5M | $6.57M | $4.23M | $3.39M | $3.52M | $2.69M | $3.52M | $627K | $478K | $0 | $0 | $0 | $0 |
| Net Debt | -$26.97M | -$37.34M | -$90.78M | -$34.84M | -$95.99M | -$192.06M | -$230.8M | -$188.76M | -$150.07M | -$184.24M | -$92.62M | -$4M | -$13.62M |
Cash Flow Statement
| Period | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 | FY 2015 | FY 2014 | FY 2013 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Currency | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD |
| Period Ending | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | 2020-12-31 | 2019-12-31 | 2018-12-31 | 2017-12-31 | 2016-12-31 | 2015-12-31 | 2014-12-31 | 2013-12-31 |
| Operating Activities | |||||||||||||
| Net Income | -$81.44M | -$61.63M | -$65.65M | -$85.64M | -$88.36M | -$74.95M | $55M | -$61.67M | -$31.97M | -$8.59M | $24.54M | $13M | -$13.61M |
| Depreciation & Amortization | $3.03M | $2.62M | $2.68M | $2.86M | $2.91M | $2.38M | $2.05M | $1.16M | $702K | $336K | $347K | $361K | $355K |
| Deferred Income Tax | $0 | $0 | $0 | $0 | $157K | $0 | $0 | $159K | $214K | -$100K | $59K | $21K | $0 |
| Stock-Based Compensation | $0 | $6.62M | $5.28M | $4.03M | $4.99M | $4.95M | $3.43M | $3.05M | $1.91M | $1.59M | $654K | $254K | $310K |
| Changes in Working Capital: | |||||||||||||
| Accounts Receivable | $1.06M | $16.4M | -$17.91M | $730K | -$120K | -$644K | $3.03M | $845K | -$485K | -$300K | $31.07M | -$31.16M | $67K |
| Inventory | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Accounts Payable | -$684K | $0 | $0 | $0 | $0 | $0 | $0 | $0 | -$3.45M | $3.14M | -$171K | $413K | $0 |
| Other Working Capital | -$8.21M | $113.74M | -$436K | -$10.94M | $8.4M | -$4.89M | $3.81M | $2.19M | $1.04M | $855K | $29.93M | -$35.35M | -$199K |
| Total Working Capital Change | -$7.83M | $130.14M | -$18.35M | -$10.21M | $8.28M | -$5.54M | $6.84M | $2.19M | -$2.41M | $3.99M | $29.76M | -$34.94M | -$132K |
| Other Non-Cash Items | $6.17M | $1.95M | $2.91M | -$87K | -$7.5M | $1.12M | -$484K | $1.76M | $4.81M | -$4.07M | -$1.99M | -$33K | -$10.9M |
| Net Cash from Operating | -$80.07M | $79.7M | -$73.12M | -$89.05M | -$79.51M | -$72.04M | $66.84M | -$53.35M | -$26.74M | -$6.83M | $53.36M | -$21.33M | -$23.97M |
| Investing Activities | |||||||||||||
| Capital Expenditures | -$1.04M | -$697K | -$970K | -$1.5M | -$3.19M | -$2.06M | -$2.28M | -$2.25M | -$2.18M | -$1.09M | -$295K | -$155K | -$301K |
| Acquisitions | $17K | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Purchases of Investments | $0 | $0 | $0 | $0 | $0 | $0 | -$78.68M | -$36.31M | $0 | $0 | $0 | $0 | $0 |
| Sales of Investments | $74.67M | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Other Investing Activities | -$197K | -$126.75M | $80.43M | $30.26M | -$61.77M | $36.36M | $0 | -$215K | -$48K | $0 | $0 | -$4K | $0 |
| Net Cash from Investing | $73.46M | -$127.45M | $79.46M | $28.76M | -$64.96M | $34.29M | -$80.96M | -$38.78M | -$2.23M | -$1.09M | -$295K | -$159K | -$301K |
| Financing Activities | |||||||||||||
| Debt Repaid | $1.24M | $827K | $663K | $689K | -$27.78M | $523K | -$60.59M | -$240K | -$242K | - | -$67K | - | - |
| Common Stock Issuance | $7K | $134K | $53.01M | $8K | $21.55M | $121K | $0 | $135M | $0 | $84.35M | $0 | $0 | $0 |
| Common Stock Repurchases | $0 | $0 | $0 | -$10K | $0 | -$121K | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Dividends Paid | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Other Financing Activities | $56K | -$663K | $0 | -$939K | -$7K | $173K | -$534K | -$2.84M | $86K | -$4.97M | -$2.15M | -$241K | $12.11M |
| Net Cash from Financing | -$1.18M | -$1.36M | $52.35M | -$1.63M | $49.32M | -$972K | $60.06M | $132.39M | $328K | $95.37M | $33.62M | $11.86M | $12.11M |
| Forex Effect | $1.83M | -$2M | -$1.91M | $631K | -$85K | -$851K | -$1M | -$1.43M | -$5.05M | $4.17M | $1.93M | $11K | $238K |
| Net Change in Cash | -$5.96M | -$51.1M | $56.78M | -$61.28M | -$95.23M | -$39.57M | $44.94M | $38.84M | -$33.69M | $91.61M | $88.62M | -$9.62M | -$11.92M |
| Supplementary Data | |||||||||||||
| Operating Cash Flow | -$80.07M | $79.7M | -$73.12M | -$89.05M | -$79.51M | -$72.04M | $66.84M | -$53.35M | -$26.74M | -$6.83M | $53.36M | -$21.33M | -$23.97M |
| Capital Expenditure | -$1.04M | -$697K | -$970K | -$1.5M | -$3.19M | -$2.06M | -$2.28M | -$2.25M | -$2.18M | -$1.09M | -$295K | -$155K | -$301K |
| Free Cash Flow | -$81.11M | $79M | -$74.09M | -$90.55M | -$82.7M | -$74.11M | $64.56M | -$55.6M | -$28.92M | -$7.92M | $53.07M | -$21.49M | -$24.27M |
| Cash at Beginning | $38.43M | $95.01M | $38.23M | $99.52M | $194.75M | $234.32M | $189.39M | $150.55M | $184.24M | $92.62M | $4M | $13.62M | $25.54M |
| Cash at End | $32.47M | $43.91M | $95.01M | $38.23M | $99.52M | $194.75M | $234.32M | $189.39M | $150.55M | $184.24M | $92.62M | $4M | $13.62M |