Aktis Oncology, Inc. (AKTS)
Aktis Oncology, Inc. is a clinical-stage biotechnology firm dedicated to advancing targeted radiopharmaceutical therapies for cancer treatment. Their core innovation lies in a proprietary miniprotein radioconjugate platform, which enables the discovery and development of potent radiopharmaceutical therapies designed to precisely deliver tumor-killing radioisotopes. Among their pipeline candidates is Nectin-4, a miniprotein radioconjugate specifically engineered to treat locally advanced or metastatic urothelial cancer. Key programs also include AKY-1189, a radioconjugate engineered to target Nectin-4 expressing tumors across various indications such as metastatic urothelial cancer, breast cancer, non-small cell lung cancer (NSCLC), colorectal cancer, and cervical cancer. Another significant therapy, AKY-2519, is under development to deliver radioisotopes to B7-H3 (CD276) expressing tumors, addressing prostate cancer, lung cancer, and other solid tumor types. Originally incorporated as HotKnot Therapeutics, Inc., the company officially rebranded to Aktis Oncology, Inc. in April 2020. Founded in 2020, Aktis Oncology maintains its headquarters in Boston, Massachusetts.
Sector: Pharmaceutical Preparations
Industry: Biotechnology
Aktis Oncology, Inc.
Trials need funding. See this company's dilution risk and cash position.
- Phase 1Recruiting
A Study of [225Ac]Ac-AKY-1189 in Patients With Solid Tumors
[225Ac]Ac-AKY-1189 (therapeutic), [64Cu]Cu-AKY-1189 (imaging)
Urothelial Carcinoma Bladder, Triple Negative Breast Cancer (TNBC) +5
NCT07020117Enrollment150StartAug 2025Primary CompletionDec 2027est.CompletionJun 2032est. - Phase 1Recruiting
A Study of [225Ac]Ac-AKY-2519 in Patients With Metastatic Castration-Resistant Prostate Cancer
[225Ac]Ac-AKY-2519 (therapeutic), [64Cu]Cu-AKY-2519 (imaging)
Castration Resistant Metastatic Prostate Cancer, Prostate Cancer +3
NCT07581184Enrollment138StartJun 2026Primary CompletionDec 2027est.CompletionJun 2032est. - Phase 1Recruiting
A Study of [225Ac]Ac-AKY-2519 in Patients With B7-H3 Expressing Solid Tumors
[225Ac]Ac-AKY-2519 (therapeutic), [64Cu]Cu-AKY-2519 (imaging)
NSCLC, NSCLC (Advanced Non-small Cell Lung Cancer) +10
NCT07887971Enrollment152StartNov 2026est.Primary CompletionDec 2028est.CompletionDec 2033est.
| Drug / Therapy | Link | ||
|---|---|---|---|
| Phase 1 | Recruiting | [225Ac]Ac-AKY-1189 (therapeutic), [64Cu]Cu-AKY-1189 (imaging) | NCT07020117 |
| Phase 1 | Recruiting | [225Ac]Ac-AKY-2519 (therapeutic), [64Cu]Cu-AKY-2519 (imaging) | NCT07581184 |
| Phase 1 | Recruiting | [225Ac]Ac-AKY-2519 (therapeutic), [64Cu]Cu-AKY-2519 (imaging) | NCT07887971 |