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Aktis Oncology, Inc. (AKTS)

Aktis Oncology, Inc. is a clinical-stage biotechnology firm dedicated to advancing targeted radiopharmaceutical therapies for cancer treatment. Their core innovation lies in a proprietary miniprotein radioconjugate platform, which enables the discovery and development of potent radiopharmaceutical therapies designed to precisely deliver tumor-killing radioisotopes. Among their pipeline candidates is Nectin-4, a miniprotein radioconjugate specifically engineered to treat locally advanced or metastatic urothelial cancer. Key programs also include AKY-1189, a radioconjugate engineered to target Nectin-4 expressing tumors across various indications such as metastatic urothelial cancer, breast cancer, non-small cell lung cancer (NSCLC), colorectal cancer, and cervical cancer. Another significant therapy, AKY-2519, is under development to deliver radioisotopes to B7-H3 (CD276) expressing tumors, addressing prostate cancer, lung cancer, and other solid tumor types. Originally incorporated as HotKnot Therapeutics, Inc., the company officially rebranded to Aktis Oncology, Inc. in April 2020. Founded in 2020, Aktis Oncology maintains its headquarters in Boston, Massachusetts.

Sector: Pharmaceutical Preparations

Industry: Biotechnology

Aktis Oncology, Inc. logo

Aktis Oncology, Inc.

NASDAQ:AKTSHealthcare
-5.46%$15.93
AH$15.93+0.00%vs close
Mkt Cap$886.02M
Float23.63M
O/S55.62M
Vol
$ Vol
RVOL
Inst Own61.6%
SI18.3%
Earnings
Dilution
Pipeline3 lead-sponsored trials·3 active0 completed

Trials need funding. See this company's dilution risk and cash position.

Clinical Trials
  • Phase 1
    Recruiting

    A Study of [225Ac]Ac-AKY-1189 in Patients With Solid Tumors

    [225Ac]Ac-AKY-1189 (therapeutic), [64Cu]Cu-AKY-1189 (imaging)

    Urothelial Carcinoma Bladder, Triple Negative Breast Cancer (TNBC) +5

    Enrollment
    150
    Start
    Aug 2025
    Primary Completion
    Dec 2027est.
    Completion
    Jun 2032est.
    NCT07020117
  • Phase 1
    Recruiting

    A Study of [225Ac]Ac-AKY-2519 in Patients With Metastatic Castration-Resistant Prostate Cancer

    [225Ac]Ac-AKY-2519 (therapeutic), [64Cu]Cu-AKY-2519 (imaging)

    Castration Resistant Metastatic Prostate Cancer, Prostate Cancer +3

    Enrollment
    138
    Start
    Jun 2026
    Primary Completion
    Dec 2027est.
    Completion
    Jun 2032est.
    NCT07581184
  • Phase 1
    Recruiting

    A Study of [225Ac]Ac-AKY-2519 in Patients With B7-H3 Expressing Solid Tumors

    [225Ac]Ac-AKY-2519 (therapeutic), [64Cu]Cu-AKY-2519 (imaging)

    NSCLC, NSCLC (Advanced Non-small Cell Lung Cancer) +10

    Enrollment
    152
    Start
    Nov 2026est.
    Primary Completion
    Dec 2028est.
    Completion
    Dec 2033est.
    NCT07887971