Annexon, Inc. (ANNX)
Annexon, Inc. is a biopharmaceutical company currently engaged in clinical trials, dedicated to the discovery and advancement of therapies for a variety of autoimmune, neurodegenerative, and ophthalmic conditions. Central to its approach is the C1q molecule, which initiates the classical complement pathway. The company targets this pathway to address specific disease mechanisms, such as those seen in antibody-mediated autoimmune disorders and complement-driven neurodegeneration. The company's developmental pipeline features several promising candidates. ANX005, a monoclonal antibody, is in advanced clinical testing, undergoing Phase II/III trials for Guillain-Barré syndrome, as well as Phase II trials for warm autoimmune hemolytic anemia, Huntington's disease, and amyotrophic lateral sclerosis. Another candidate, ANX009, is currently in Phase Ib studies for lupus nephritis. Additionally, ANX007 is progressing through Phase II clinical trials for the treatment of geographic atrophy, an eye disease. Further investigational assets include ANX105, a monoclonal antibody being developed for neurodegenerative indications, and ANX1502, an oral small molecule under investigation for specific autoimmune conditions. Annexon, Inc. was established in 2011 and operates from its headquarters in Brisbane, California.
Sector: Pharmaceutical Preparations
Industry: Biotechnology
Annexon, Inc.
NASDAQ:ANNXHealthcare · Biotechnology
+1.00%$4.05
AH$4.08+0.74%vs close
Mkt Cap$767.8M
Float153.79M
O/S189.58M
Vol
$ Vol
RVOL
Inst Own94.5%
SI20.6%
Earnings
Dilution
Financials Summary
Revenue$0
Net Income-$206.69M
Total Assets$277.57M
Free Cash Flow-$186.49M
Debt & Equity
Debt 11%
Equity 89%
Total Debt$26.2M
Total Equity$211.65M
Shares Outstanding
Short Interest
Split History
No splits on record
Nothing in ANNX's public trading history: no forward or reverse split has affected the share count.
Balance Sheet Details
Assets$277.57M
Liabilities$65.92M
Accounts Receivable$0
Accounts Payable$14.93M
Inventory$0
PP&E (Net)$25.8M
Goodwill$0
Intangible Assets$0
Income Statement
| Period | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 |
|---|---|---|---|---|---|---|---|---|---|
| Currency | USD | USD | USD | USD | USD | USD | USD | USD | USD |
| Period Ending | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | 2020-12-31 | 2019-12-31 | 2018-12-31 | 2017-12-31 |
| Revenue | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| YoY Growth | - | - | - | - | - | - | - | - | - |
| Cost of Revenue | $3.69M | $3.45M | $0 | $0 | $0 | $0 | $0 | $488K | $271K |
| Gross Profit | -$3.69M | -$3.45M | $0 | $0 | $0 | $0 | $0 | -$488K | -$271K |
| Gross Margin | - | - | - | - | - | - | - | - | - |
| Research and Development | $184.7M | $119.45M | $113.76M | $112.5M | $100.07M | $49.27M | $24.52M | $15.53M | $17.85M |
| Selling, General, and Administrative | $31.71M | $34.63M | $28.02M | $30.95M | $30.65M | $14.2M | $7.99M | $3.62M | $2.35M |
| Other | -$3.69M | -$3.45M | $1.95M | $2.15M | $0 | $0 | $0 | $844K | $0 |
| Total Operating Expenses | $212.72M | $150.62M | $143.72M | $145.6M | $130.71M | $63.47M | $32.52M | $19.15M | $20.21M |
| Operating Income (EBIT) | -$216.41M | -$154.07M | -$143.72M | -$145.6M | -$130.71M | -$63.47M | -$32.52M | -$19.15M | -$20.48M |
| Operating Margin | - | - | - | - | - | - | - | - | - |
| Interest Expense | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Interest Income | $9.72M | $15.87M | $9.49M | $3.65M | $390K | $0 | $0 | $0 | $370K |
| Other Income (Expense) | $9.72M | $15.87M | $9.49M | $3.65M | $390K | $57K | -$4.66M | $844K | $1.77M |
| Income Before Tax (EBT) | -$206.69M | -$138.2M | -$134.24M | -$141.95M | -$130.32M | -$63.41M | -$37.18M | -$18.3M | -$18.71M |
| Income Tax Expense | $0 | $0 | $0 | $0 | $0 | $0 | $4K | $1K | $1K |
| Net Income | -$206.69M | -$138.2M | -$134.24M | -$141.95M | -$130.32M | -$63.41M | -$37.18M | -$18.3M | -$18.71M |
| Net Income Margin | - | - | - | - | - | - | - | - | - |
| Supplementary Data | |||||||||
| EPS | -1.34 | -1.01 | -1.77 | -2.60 | -3.34 | -3.70 | -0.97 | -1.60 | -0.49 |
| Diluted EPS | -1.34 | -1.01 | -1.77 | -2.60 | -3.34 | -3.70 | -0.97 | -1.60 | -0.49 |
| Weighted Average OS | 155.11M | 137.40M | 75.67M | 54.67M | 38.32M | 16.96M | 38.22M | 11.45M | 38.22M |
| EBITDA | -$204.52M | -$136.05M | -$132.09M | -$139.84M | -$128.18M | -$62.8M | -$32.02M | -$18.66M | -$20.21M |
| EBITDA Margin | - | - | - | - | - | - | - | - | - |
Balance Sheet
| Period | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 |
|---|---|---|---|---|---|---|---|---|---|
| Currency | USD | USD | USD | USD | USD | USD | USD | USD | USD |
| Period Ending | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | 2020-12-31 | 2019-12-31 | 2018-12-31 | 2017-12-31 |
| Assets | |||||||||
| Current Assets | |||||||||
| Cash and Cash Equivalents | $162.05M | $49.5M | $225.11M | $140.02M | $74.84M | $268.56M | $43.93M | $44.17M | $2.97M |
| Short-Term Investments | $76.29M | $262.52M | $34.61M | $102.64M | $167.87M | $82.64M | $0 | $0 | $0 |
| Cash and Short-Term Investments | $238.34M | $312.02M | $259.72M | $242.66M | $242.72M | $351.21M | $43.93M | $44.17M | $2.97M |
| Accounts Receivable | $0 | $0 | $0 | $0 | $0 | $3K | $79K | $225K | $582K |
| Inventory | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Other Current Assets | $1.24M | $1.1M | $63K | $203K | $463K | $0 | $0 | $0 | $0 |
| Total Current Assets | $242.19M | $316.46M | $263.86M | $248.1M | $247.69M | $354.01M | $45.41M | $45.71M | $4.89M |
| Long-Term Assets | |||||||||
| Property, Plant & Equipment Net | $25.8M | $29.34M | $32.78M | $35.97M | $38.18M | $1.94M | $2.14M | $2.35M | $2.82M |
| Goodwill | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Intangible Assets | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Long-Term Investments | $0 | $0 | $0 | $1.03M | $0 | $0 | $0 | $0 | $0 |
| Deferred Tax Assets | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Other Long-Term Assets | $9.58M | $4.27M | $1.03M | $0 | $1.17M | $0 | $2.35M | $98K | $112K |
| Total Long-Term Assets | $35.38M | $33.61M | $33.81M | $37M | $39.35M | $1.94M | $4.49M | $2.44M | $2.93M |
| Other Assets | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Total Assets | $277.57M | $350.07M | $297.67M | $285.1M | $287.04M | $355.95M | $49.9M | $48.15M | $7.82M |
| Liabilities | |||||||||
| Current Liabilities | |||||||||
| Accounts Payable | $14.93M | $10.43M | $5.49M | $7.42M | $11.15M | $3.73M | $2.37M | $1.27M | $1.52M |
| Short-Term Debt | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Current Income Tax Payable | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Current Unearned Revenue | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Other Current Liabilities | $8.03M | $5.97M | $5.65M | $180K | $2.06M | $2.93M | $366K | $342K | $971K |
| Total Current Liabilities | $42.63M | $30.51M | $17.93M | $22.36M | $21.74M | $10.62M | $4.93M | $3.33M | $2.92M |
| Long-Term Liabilities | |||||||||
| Long-Term Debt | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $107.22M | $0 |
| Long-Term Unearned Revenue | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Long-Term Deferred Tax Liabilities | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Other Long-Term Liabilities | $0 | $0 | $0 | $0 | $0 | $1.05M | $1.44M | -$100.28M | $51.12M |
| Total Long-Term Liabilities | $23.29M | $26.45M | $29.19M | $31.54M | $33.39M | $1.05M | $1.44M | $6.94M | $51.12M |
| Other Liabilities | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Total Liabilities | $65.92M | $56.97M | $47.12M | $53.9M | $55.13M | $11.67M | $6.37M | $10.27M | $54.03M |
| Stockholders' Equity | |||||||||
| Preferred Stock | $0 | $0 | $0 | $0 | $0 | $0 | $143.98M | $102.08M | $48.97M |
| Common Stock | $149K | $109K | $78K | $48K | $39K | $38K | $4K | $4K | $3K |
| Retained Earnings | -$917.39M | -$710.7M | -$572.5M | -$438.26M | -$296.31M | -$165.99M | -$102.58M | -$65.4M | -$47.09M |
| Comprehensive Income & Other | -$29K | $10K | -$52K | -$372K | -$180K | -$77K | -$80K | -$66K | -$26K |
| Other Stockholders' Equity | $1.13B | $1B | $822.98M | $669.41M | $528.18M | $510.23M | $146.11M | $103.27M | $879K |
| Total Equity | $211.65M | $293.11M | $250.56M | $231.19M | $231.91M | $344.28M | $43.53M | $37.88M | -$46.21M |
| Minority Interest | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Total Liabilities and Equity | $277.57M | $350.07M | $297.67M | $285.1M | $287.04M | $355.95M | $49.9M | $48.15M | $7.82M |
| Supplementary Data | |||||||||
| Total Debt | $26.2M | $28.97M | $31.36M | $32.86M | $34.59M | $0 | $0 | $107.22M | $48.97M |
| Net Debt | -$135.85M | -$20.53M | -$193.75M | -$107.16M | -$40.25M | -$268.56M | -$43.93M | $63.05M | $46.01M |
Cash Flow Statement
| Period | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 |
|---|---|---|---|---|---|---|---|---|---|
| Currency | USD | USD | USD | USD | USD | USD | USD | USD | USD |
| Period Ending | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | 2020-12-31 | 2019-12-31 | 2018-12-31 | 2017-12-31 |
| Operating Activities | |||||||||
| Net Income | -$206.69M | -$138.2M | -$134.24M | -$141.95M | -$130.32M | -$63.41M | -$37.18M | -$18.3M | -$18.71M |
| Depreciation & Amortization | $2.17M | $2.15M | $2.15M | $2.11M | $2.14M | $667K | $493K | $488K | $271K |
| Deferred Income Tax | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Stock-Based Compensation | $16.42M | $19.43M | $18.18M | $18.52M | $16.26M | $4.89M | $2.04M | $408K | $401K |
| Changes in Working Capital: | |||||||||
| Accounts Receivable | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Inventory | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Accounts Payable | $4.49M | $4.94M | -$2.08M | -$287K | $3.86M | $1.51M | $931K | -$253K | $144K |
| Other Working Capital | -$261K | $1.43M | -$3.73M | $4.03M | -$575K | $3.2M | -$306K | $731K | -$1.37M |
| Total Working Capital Change | $4.23M | $6.36M | -$5.8M | $3.74M | $3.28M | $4.72M | $625K | $478K | -$1.22M |
| Other Non-Cash Items | -$2.48M | -$7.75M | -$1.43M | $1.28M | $2.53M | $53K | $5.67M | -$260K | $799K |
| Net Cash from Operating | -$186.36M | -$118.01M | -$121.14M | -$116.31M | -$106.11M | -$53.09M | -$28.36M | -$17.19M | -$19.26M |
| Investing Activities | |||||||||
| Capital Expenditures | -$137K | -$15K | -$193K | -$6.53M | -$1.65M | -$464K | -$267K | -$17K | -$567K |
| Acquisitions | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Purchases of Investments | -$212.21M | -$583.93M | -$108.09M | -$113.2M | -$225.6M | -$82.7M | $0 | $0 | $0 |
| Sales of Investments | $402.4M | $365.15M | $178.98M | $178.17M | $139.02M | $0 | $0 | $0 | $0 |
| Other Investing Activities | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Net Cash from Investing | $190.05M | -$218.8M | $70.7M | $58.44M | -$88.24M | -$83.16M | -$267K | -$17K | -$567K |
| Financing Activities | |||||||||
| Debt Repaid | - | - | - | - | - | - | - | - | - |
| Common Stock Issuance | $110.47M | $161.87M | $135.51M | $130.48M | $1.79M | $267.02M | $0 | $58.46M | $42K |
| Common Stock Repurchases | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Dividends Paid | $0 | $0 | $0 | $0 | $0 | -$6.22M | $0 | $0 | $0 |
| Other Financing Activities | -$1.62M | -$665K | $14K | -$7.57M | $0 | $3.27M | -$1.6M | $121K | $42K |
| Net Cash from Financing | $108.86M | $161.21M | $135.52M | $122.91M | $1.79M | $360.88M | $28.39M | $58.46M | $42K |
| Forex Effect | $2K | -$15K | $5K | $1K | -$1.17M | $9K | -$14K | -$40K | -$24K |
| Net Change in Cash | $112.55M | -$175.61M | $85.09M | $65.04M | -$193.72M | $224.63M | -$244K | $41.21M | -$19.81M |
| Supplementary Data | |||||||||
| Operating Cash Flow | -$186.36M | -$118.01M | -$121.14M | -$116.31M | -$106.11M | -$53.09M | -$28.36M | -$17.19M | -$19.26M |
| Capital Expenditure | -$137K | -$15K | -$193K | -$6.53M | -$1.65M | -$464K | -$267K | -$17K | -$567K |
| Free Cash Flow | -$186.49M | -$118.02M | -$121.33M | -$122.83M | -$107.76M | -$53.55M | -$28.63M | -$17.21M | -$19.83M |
| Cash at Beginning | $50.53M | $226.14M | $141.05M | $76.01M | $268.56M | $43.93M | $44.17M | $2.97M | $22.77M |
| Cash at End | $163.08M | $50.53M | $226.14M | $141.05M | $74.84M | $268.56M | $43.93M | $44.17M | $2.97M |