aTYR PHARMA INC (ATYR)
aTyr Pharma, Inc., a biopharmaceutical firm established in San Diego, California, in 2005, is dedicated to the discovery and advancement of therapeutic solutions. Operating within the United States, the company's research focuses on pioneering novel immunological pathways to address various medical conditions. Its primary investigational drug, efzofitimod, functions as a selective modulator of NRP2. This compound is currently undergoing a Phase III clinical trial for pulmonary sarcoidosis. Additionally, efzofitimod is being evaluated in a Phase 1b/2a clinical study for the treatment of other interstitial lung diseases (ILDs), including conditions such as chronic hypersensitivity pneumonitis and ILDs linked to connective tissue diseases. Beyond its lead candidate, aTyr Pharma's pipeline features ATYR0101, a fusion protein derived from a domain of aspartyl-tRNA synthetase, which is in preclinical stages of development for combating fibrosis. The company is also progressing with ATYR0750, a domain sourced from alanyl-tRNA synthetase, intended for the management of liver disorders. Furthermore, aTyr Pharma has entered into a strategic collaboration and licensing agreement with Kyorin Pharmaceutical Co., Ltd. This partnership is focused on the development and commercialization of efzofitimod for interstitial lung diseases specifically within the Japanese market.
Sector: Biological Products, (No Diagnostic Substances)
Industry: Biotechnology
aTyr Pharma, Inc.
NASDAQ:ATYRHealthcare · Biotechnology
-8.01%$4.94
AH$4.94+0.00%vs close
Mkt Cap-
Float2.44M
O/S-
Vol
$ Vol
RVOL
Inst Own39.5%
Earnings
Dilution
Financials Summary
Revenue$190K
Net Income-$74.12M
Total Assets$94.16M
Free Cash Flow-$62.06M
Debt & Equity
Debt 15%
Equity 85%
Total Debt$12.03M
Total Equity$67.48M
Shares Outstanding
Short Interest
Split History1 split · 1 reverse
2-year cumulative
1:40
Nasdaq bars a compliance period at 1:250
- 1:40Reverse splitOct 29, 202640 shares → 1
Balance Sheet Details
Assets$94.16M
Liabilities$26.88M
Accounts Receivable$873K
Accounts Payable$3.89M
Inventory$0
PP&E (Net)$10.38M
Goodwill$0
Intangible Assets$0
Income Statement
| Period | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 | FY 2015 | FY 2014 | FY 2013 | FY 2012 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Currency | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD |
| Period Ending | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | 2020-12-31 | 2019-12-31 | 2018-12-31 | 2017-12-31 | 2016-12-31 | 2015-12-31 | 2014-12-31 | 2013-12-31 | 2012-12-31 |
| Revenue | $190K | $235K | $353K | $10.39M | $0 | $10.46M | $422K | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| YoY Growth | -19.1% | -33.4% | -96.6% | - | - | 2377.5% | - | - | - | - | - | - | - | - |
| Cost of Revenue | $1.55M | $0 | $0 | $1.7M | $1.3M | $17.29M | $14.05M | $746K | $713K | $900K | $0 | $0 | $0 | $540K |
| Gross Profit | -$1.36M | $235K | $353K | $8.69M | -$1.3M | -$6.84M | -$13.63M | -$746K | -$713K | -$900K | $0 | $0 | $0 | -$540K |
| Gross Margin | -717.4% | 100.0% | 100.0% | 83.7% | - | -65.4% | -3228.9% | - | - | - | - | - | - | - |
| Research and Development | $60.22M | $54.37M | $42.29M | $42.81M | $23.26M | $17.29M | $14.05M | $20.39M | $30.07M | $44.25M | $34.5M | $16.78M | $13.83M | $7.75M |
| Selling, General, and Administrative | $17.6M | $13.78M | $12.98M | $12.29M | $10.75M | $9.07M | $9.35M | $11.69M | $16.36M | $14.19M | $13.11M | $6.78M | $5.71M | $4.31M |
| Other | -$1.55M | $0 | $0 | $0 | -$1.3M | -$17.29M | -$14.05M | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Total Operating Expenses | $76.26M | $68.15M | $55.27M | $55.09M | $32.71M | $9.07M | $9.35M | $32.07M | $46.43M | $58.44M | $47.62M | $23.55M | $19.54M | $12.06M |
| Operating Income (EBIT) | -$77.63M | -$67.91M | -$54.92M | -$46.4M | -$34.02M | -$15.91M | -$22.98M | -$32.82M | -$47.15M | -$59.34M | -$47.62M | -$23.55M | -$19.54M | -$12.6M |
| Operating Margin | -40856.3% | -28899.6% | -15557.8% | -446.8% | - | -152.2% | -5445.0% | - | - | - | - | - | - | - |
| Interest Expense | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $832K | $444K | $272K |
| Interest Income | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $65K | $0 | $0 | $0 | $0 |
| Other Income (Expense) | $3.51M | $3.89M | $4.52M | $1.06M | $238K | -$319K | -$785K | -$1.7M | -$1.06M | $1.44M | -$357K | -$796K | -$472K | -$261K |
| Income Before Tax (EBT) | -$74.12M | -$64.02M | -$50.4M | -$45.34M | -$33.78M | -$16.23M | -$23.76M | -$34.52M | -$48.21M | -$57.9M | -$47.97M | -$24.35M | -$20.01M | -$12.86M |
| Income Tax Expense | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | -$49K | $0 | $0 | $0 | $0 |
| Net Income | -$74.12M | -$64.02M | -$50.39M | -$45.34M | -$33.77M | -$16.22M | -$23.6M | -$34.52M | -$48.21M | -$57.85M | -$47.97M | -$24.35M | -$20.01M | -$17.61M |
| Net Income Margin | -39009.5% | -27243.8% | -14274.5% | -436.5% | - | -155.2% | -5593.1% | - | - | - | - | - | - | - |
| Supplementary Data | ||||||||||||||
| EPS | -0.80 | -0.86 | -0.94 | -1.60 | -1.77 | -1.77 | -7.03 | -16.13 | -26.16 | -34.20 | -42.42 | -422.73 | -429.90 | -0.45 |
| Diluted EPS | -0.80 | -0.86 | -0.94 | -1.60 | -1.77 | -1.77 | -7.03 | -16.13 | -26.16 | -34.20 | -42.42 | -415.63 | -397.39 | -0.45 |
| Weighted Average OS | 92.99M | 74.26M | 53.61M | 28.42M | 19.08M | 9.16M | 3.36M | 2.14M | 1.84M | 1.69M | 1.13M | 58,586 | 50,363 | 39.42M |
| EBITDA | -$72.56M | -$62.48M | -$47.66M | -$43.65M | -$32.47M | -$14.64M | -$21.61M | -$32.07M | -$46.43M | -$57M | -$45.35M | -$22.73M | -$18.83M | -$12.05M |
| EBITDA Margin | -38192.1% | -26588.1% | -13500.3% | -420.3% | - | -140.1% | -5121.3% | - | - | - | - | - | - | - |
Balance Sheet
| Period | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 | FY 2015 | FY 2014 | FY 2013 | FY 2012 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Currency | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD |
| Period Ending | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | 2020-12-31 | 2019-12-31 | 2018-12-31 | 2017-12-31 | 2016-12-31 | 2015-12-31 | 2014-12-31 | 2013-12-31 | 2012-12-31 |
| Assets | ||||||||||||||
| Current Assets | ||||||||||||||
| Cash and Cash Equivalents | $10.74M | $11.05M | $22.54M | $9.98M | $2.34M | $16.95M | $9.21M | $22.96M | $21.09M | $38.39M | $53.02M | $13.9M | $36.46M | $3.67M |
| Short-Term Investments | $67.94M | $61.07M | $75.62M | $56.16M | $105.58M | $14.74M | $21.93M | $26.58M | $64.03M | $33.76M | $42.51M | $1.95M | $0 | $0 |
| Cash and Short-Term Investments | $78.69M | $72.13M | $98.17M | $66.15M | $107.91M | $31.69M | $31.14M | $49.55M | $85.12M | $72.15M | $95.53M | $15.85M | $36.46M | $3.67M |
| Accounts Receivable | $873K | $1.74M | $2.44M | $11.78M | $435K | $2.04M | $100K | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Inventory | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Other Current Assets | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $816K |
| Total Current Assets | $80.24M | $81.95M | $102.99M | $80.87M | $113.57M | $35.53M | $31.93M | $50.8M | $86.98M | $74.77M | $97.95M | $16.51M | $37.02M | $4.49M |
| Long-Term Assets | ||||||||||||||
| Property, Plant & Equipment Net | $10.38M | $11.86M | $14.05M | $11.56M | $1.81M | $2.98M | $4.09M | $1.85M | $2.28M | $1.42M | $1.79M | $1.93M | $2.5M | $2.58M |
| Goodwill | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Intangible Assets | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Long-Term Investments | $2.23M | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $4M | $29.81M | $0 | $0 | $69K |
| Deferred Tax Assets | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Other Long-Term Assets | $1.31M | $3.02M | $3.62M | $3.36M | $158K | $213K | $172K | $90K | $90K | $333K | $118K | $2.21M | $260K | $331K |
| Total Long-Term Assets | $13.93M | $14.88M | $17.66M | $14.91M | $1.97M | $3.19M | $4.26M | $1.94M | $2.37M | $5.76M | $31.73M | $4.13M | $2.77M | $2.98M |
| Other Assets | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Total Assets | $94.16M | $96.83M | $120.65M | $95.79M | $115.54M | $38.73M | $36.19M | $52.75M | $89.36M | $80.52M | $129.68M | $20.64M | $39.79M | $7.47M |
| Liabilities | ||||||||||||||
| Current Liabilities | ||||||||||||||
| Accounts Payable | $3.89M | $4.32M | $3.53M | $3.11M | $1.03M | $1.43M | $847K | $1.04M | $2.28M | $2.61M | $3.87M | $1.43M | $1.05M | $593K |
| Short-Term Debt | $1.47M | $0 | $0 | $0 | $0 | $0 | $8.74M | $7.77M | $5.01M | $339K | $3.37M | $5.13M | $728K | $875K |
| Current Income Tax Payable | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Current Unearned Revenue | $0 | $0 | $0 | $0 | $0 | $0 | $208K | $0 | $0 | $0 | $0 | $0 | $0 | $255K |
| Other Current Liabilities | $6.8M | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $130K | $315K | $614K | $2.02M | $444K |
| Total Current Liabilities | $15.15M | $14.97M | $16.42M | $13.86M | $6.01M | $5.86M | $12.92M | $10.83M | $10.39M | $8.53M | $12.15M | $10.11M | $5.21M | $3.53M |
| Long-Term Liabilities | ||||||||||||||
| Long-Term Debt | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $8.26M | $14.72M | $9.2M | $1.78M | $5.14M | $6.16M | $3.67M |
| Long-Term Unearned Revenue | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $1.02M |
| Long-Term Deferred Tax Liabilities | $1.16M | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Other Long-Term Liabilities | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $701K | $96.4M | $94.5M | $512K |
| Total Long-Term Liabilities | $11.73M | $12.03M | $13.77M | $10.64M | $398K | $1.38M | $2.24M | $8.26M | $14.72M | $9.2M | $2.48M | $101.54M | $100.66M | $5.2M |
| Other Liabilities | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Total Liabilities | $26.88M | $27M | $30.18M | $24.5M | $6.41M | $7.24M | $15.16M | $19.1M | $25.11M | $17.72M | $14.63M | $111.65M | $105.87M | $8.73M |
| Stockholders' Equity | ||||||||||||||
| Preferred Stock | $0 | $0 | $0 | $0 | $0 | $0 | $2K | $2K | $2K | $0 | $0 | $0 | $0 | $63.23M |
| Common Stock | $98K | $84K | $63K | $29K | $28K | $11K | $4K | $31K | $30K | $24K | $24K | $1K | $1K | $6K |
| Retained Earnings | -$606.16M | -$532.05M | -$468.02M | -$417.63M | -$372.3M | -$338.53M | -$322.3M | -$298.7M | -$264.19M | -$215.98M | -$158.12M | -$110.15M | -$85.8M | -$64.52M |
| Comprehensive Income & Other | -$8K | -$40K | -$74K | -$433K | -$263K | -$43K | -$40K | -$60K | -$120K | -$76K | -$171K | -$69K | -$69K | $0 |
| Other Stockholders' Equity | $673.55M | $601.98M | $558.62M | $489.07M | $481.57M | $370.17M | $343.49M | $332.32M | $328.4M | $278.76M | $273.15M | $19.14M | $17.3M | $63.23M |
| Total Equity | $67.48M | $70.02M | $90.66M | $71.46M | $109.3M | $31.65M | $21.19M | $33.65M | $64.25M | $62.8M | $115.05M | -$91.01M | -$68.5M | -$1.28M |
| Minority Interest | -$192K | -$187K | -$188K | -$180K | -$175K | -$166K | -$160K | $0 | $0 | $0 | $0 | $0 | $2.41M | $25K |
| Total Liabilities and Equity | $94.36M | $97.02M | $120.84M | $95.97M | $115.71M | $38.89M | $36.35M | $52.75M | $89.36M | $80.52M | $129.68M | $20.64M | $37.37M | $7.44M |
| Supplementary Data | ||||||||||||||
| Total Debt | $12.03M | $13.28M | $15.1M | $11.53M | $1.38M | $2.24M | $11.73M | $16.03M | $19.73M | $9.54M | $5.14M | $10.28M | $6.89M | $4.54M |
| Net Debt | $1.29M | $2.23M | -$7.45M | $1.55M | -$958K | -$14.71M | $2.52M | -$6.93M | -$1.36M | -$28.85M | -$47.88M | -$3.62M | -$29.57M | $867K |
Cash Flow Statement
| Period | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 | FY 2015 | FY 2014 | FY 2013 | FY 2012 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Currency | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD |
| Period Ending | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | 2020-12-31 | 2019-12-31 | 2018-12-31 | 2017-12-31 | 2016-12-31 | 2015-12-31 | 2014-12-31 | 2013-12-31 | 2012-12-31 |
| Operating Activities | ||||||||||||||
| Net Income | -$74.12M | -$64.02M | -$50.39M | -$45.34M | -$33.77M | -$16.22M | -$23.76M | -$34.52M | -$48.21M | -$57.85M | -$47.97M | -$24.35M | -$20.01M | -$17.61M |
| Depreciation & Amortization | $1.55M | $1.54M | $2.74M | $1.7M | $1.3M | $1.27M | $1.37M | $746K | $713K | $900K | $869K | $829K | $714K | $540K |
| Deferred Income Tax | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Stock-Based Compensation | $5M | $2.99M | $2.6M | $2.15M | $1.61M | $1.47M | $1.78M | $0 | $0 | $0 | $4.86M | $1.79M | $155K | $0 |
| Changes in Working Capital: | ||||||||||||||
| Accounts Receivable | $863K | $402K | $9.05M | -$11.92M | $1.6M | -$1.94M | $58K | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Inventory | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Accounts Payable | $0 | -$1.34M | $3.26M | $0 | $47K | $1.76M | $0 | -$2.06M | -$2.49M | $0 | $0 | $0 | $0 | $750K |
| Other Working Capital | $6.59M | -$5.98M | $2.7M | $11.09M | -$4.24M | -$2.08M | $148K | $610K | $761K | -$1.35M | $3.28M | -$1.25M | $1.85M | $37K |
| Total Working Capital Change | $7.45M | -$6.92M | $15.01M | -$833K | -$2.59M | -$2.26M | $206K | -$1.45M | -$1.73M | -$1.35M | $3.28M | -$1.25M | $1.85M | $787K |
| Other Non-Cash Items | -$1.87M | -$2.71M | -$3.19M | $441K | $363K | $453K | $395K | $7.7M | $10.78M | $7.25M | $2.17M | $156K | -$15K | $4.9M |
| Net Cash from Operating | -$61.99M | -$69.12M | -$33.22M | -$41.89M | -$33.08M | -$15.3M | -$20.01M | -$31.06M | -$42.36M | -$52.86M | -$36.8M | -$22.82M | -$17.31M | -$11.38M |
| Investing Activities | ||||||||||||||
| Capital Expenditures | -$77K | -$65K | -$4.21M | -$1.64M | -$192K | -$202K | -$79K | -$594K | -$1.31M | -$600K | -$664K | -$249K | -$644K | -$598K |
| Acquisitions | $12K | $7K | $0 | $0 | $50K | $18K | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Purchases of Investments | -$93.44M | -$69.1M | -$106.98M | -$42.12M | -$126.51M | -$21.07M | -$40.65M | -$40.3M | -$77.67M | -$28.09M | -$109.44M | -$5.4M | $0 | $0 |
| Sales of Investments | $86.6M | $86.39M | $91.05M | $90.83M | $35.08M | $28.15M | $45.6M | $78.06M | $51.35M | $62.22M | $38.12M | $3.4M | $0 | $0 |
| Other Investing Activities | $1.85M | $0 | $15K | $179K | $0 | $0 | $51K | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Net Cash from Investing | -$5.05M | $17.23M | -$20.13M | $47.24M | -$91.57M | $6.9M | $4.92M | $37.17M | -$27.64M | $33.53M | -$71.99M | -$2.25M | -$644K | -$598K |
| Financing Activities | ||||||||||||||
| Debt Repaid | $539K | $497K | $394K | $66K | - | $9.08M | $8M | $4.67M | -$9.87M | -$4.53M | $5.24M | -$3.44M | -$12M | -$1.65M |
| Common Stock Issuance | $66.42M | $40.26M | $66.52M | $5.47M | $109.95M | $25.22M | $9.32M | $379K | $42.48M | $163K | $76.9M | $0 | $0 | $4K |
| Common Stock Repurchases | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Dividends Paid | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Other Financing Activities | $0 | $100K | $105K | $45K | $73K | $10K | $13K | $50K | $361K | $163K | $0 | -$927K | $77K | $0 |
| Net Cash from Financing | $66.01M | $39.86M | $66.23M | $5.45M | $110.03M | $16.14M | $1.34M | -$4.24M | $52.7M | $4.7M | $147.92M | $2.51M | $50.74M | $1.66M |
| Forex Effect | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Net Change in Cash | -$1.03M | -$12.02M | $12.88M | $10.81M | -$14.62M | $7.74M | -$13.75M | $1.87M | -$17.3M | -$14.64M | $39.13M | -$22.56M | $32.78M | $0 |
| Supplementary Data | ||||||||||||||
| Operating Cash Flow | -$61.99M | -$69.12M | -$33.22M | -$41.89M | -$33.08M | -$15.3M | -$20.01M | -$31.06M | -$42.36M | -$52.86M | -$36.8M | -$22.82M | -$17.31M | -$11.38M |
| Capital Expenditure | -$77K | -$65K | -$4.21M | -$1.64M | -$192K | -$202K | -$79K | -$594K | -$1.31M | -$600K | -$664K | -$249K | -$644K | -$598K |
| Free Cash Flow | -$62.06M | -$69.18M | -$37.44M | -$43.53M | -$33.27M | -$15.5M | -$20.09M | -$31.66M | -$43.68M | -$53.46M | -$37.46M | -$23.07M | -$17.95M | -$11.98M |
| Cash at Beginning | $14.01M | $26.03M | $13.15M | $2.34M | $16.95M | $9.21M | $22.96M | $21.09M | $38.39M | $53.02M | $13.9M | $36.46M | $3.67M | $0 |
| Cash at End | $12.98M | $14.01M | $26.03M | $13.15M | $2.34M | $16.95M | $9.21M | $22.96M | $21.09M | $38.39M | $53.02M | $13.9M | $36.46M | $3.67M |