ANAVEX LIFE SCIENCES CORP. (AVXL)
Operating as a clinical-stage biopharmaceutical entity, Anavex Life Sciences Corp. specializes in developing therapeutic drug candidates for various central nervous system (CNS) conditions. Its leading compound, ANAVEX 2-73, is currently in advanced development, undergoing Phase III clinical evaluation for both Alzheimer's disease and pediatric Rett syndrome. This same drug is also in Phase II trials for Parkinson's disease and is being explored in preclinical studies for a wider range of disorders, including epilepsy, infantile spasms, Fragile X syndrome, Angelman syndrome, multiple sclerosis, and tuberous sclerosis complex. Another significant drug candidate, ANAVEX 3-71, has progressed to Phase I clinical trials for frontotemporal dementia and other forms of dementia, with additional preclinical investigation underway for neurodegenerative illnesses like Alzheimer's and Parkinson's. The company's earlier-stage portfolio includes ANAVEX 1-41, a sigma-1 receptor agonist targeting depression, stroke, Parkinson's, and Alzheimer's diseases; ANAVEX 1066, a mixed sigma-1/sigma-2 ligand with potential applications in neuropathic and visceral pain; and ANAVEX 1037, aimed at treating prostate and pancreatic cancers. Anavex Life Sciences Corp. was founded in 2004 and maintains its headquarters in New York, New York.
Sector: Biological Products, (No Diagnostic Substances)
Industry: Biotechnology
Anavex Life Sciences Corp.
Trials need funding. See this company's dilution risk and cash position.
- Phase 3Completed
ANAVEX2-73 Study in Patients With Rett Syndrome
ANAVEX2-73, Placebo
Rett Syndrome
NCT03941444Enrollment33StartMay 2019Primary CompletionSep 2021CompletionSep 2021 - Phase 2/3Completed
ANAVEX2-73 for Treatment of Early Alzheimer's Disease
High dose ANAVEX2-73, Mid dose ANAVEX2-73
Alzheimer Disease
NCT03790709Enrollment509StartJul 2018Primary CompletionJun 2022CompletionJun 2022 - Phase 2/3Completed
ANAVEX2-73 Study in Pediatric Patients With Rett Syndrome
ANAVEX2-73 oral liquid, Placebo oral liquid
Rett Syndrome
NCT04304482Enrollment92StartJul 2020Primary CompletionJun 2023CompletionJun 2023 - Phase 2/3Completed
OLE of Phase 2b/3 Study ANAVEX2-73-AD-004
ANAVEX2-73
Alzheimer Disease
NCT04314934Enrollment300StartOct 2019Primary CompletionJun 2024CompletionJun 2024 - Phase 2Completed
Phase 2a Dose Finding, PK/PD and 12 Month Exploratory Efficacy Study of ANAVEX2-73 in Patients With Alzheimer's Disease
ANAVEX2-73 Oral, ANAVEX2-73 Intravenous
Alzheimer's Disease
NCT02244541Enrollment32StartDec 2014Primary CompletionNov 2015CompletionNov 2016 - Phase 2Completed
An Extension Study of ANAVEX2-73 in Patients With Mild to Moderate Alzheimer's Disease
ANAVEX2-73
Alzheimer's Disease
NCT02756858Enrollment21StartMar 2016Primary CompletionNov 2020CompletionNov 2020 - Phase 2Completed
Study of ANAVEX2-73 in Patients With Rett Syndrome
ANAVEX2-73, Placebo
Rett Syndrome
NCT03758924Enrollment31StartFeb 2019Primary CompletionOct 2020CompletionOct 2020 - Phase 2Completed
ANAVEX2-73 Study in Parkinson's Disease Dementia
High dose ANAVEX2-73, Mid dose ANAVEX2-73
Parkinsons Disease With Dementia
NCT03774459Enrollment132StartJul 2018Primary CompletionSep 2020CompletionSep 2020 - Phase 2Completed
OLE Study for Patients With Parkinson's Disease With Dementia Enrolled in Study ANAVEX2-73-PDD-001
ANAVEX2-73
Parkinson Disease Dementia
NCT04575259Enrollment132StartOct 2019Primary CompletionMay 2022CompletionJun 2022 - Phase 2Active, not recruiting
A Study of ANAVEX3-71 in Adults With Schizophrenia
ANAVEX3-71 oral capsules, Placebo oral capsules
Schizophrenia
NCT06245213Enrollment71StartMar 2024Primary CompletionJun 2025est.CompletionJun 2025est. - Phase 1Completed
Phase 1 Study of ANAVEX3-71
ANAVEX3-71, Placebo
Healthy
NCT04442945Enrollment36StartJul 2020Primary CompletionSep 2021CompletionOct 2021
| Drug / Therapy | Link | ||
|---|---|---|---|
| Phase 3 | Completed | ANAVEX2-73, Placebo | NCT03941444 |
| Phase 2/3 | Completed | High dose ANAVEX2-73, Mid dose ANAVEX2-73 | NCT03790709 |
| Phase 2/3 | Completed | ANAVEX2-73 oral liquid, Placebo oral liquid | NCT04304482 |
| Phase 2/3 | Completed | ANAVEX2-73 | NCT04314934 |
| Phase 2 | Completed | ANAVEX2-73 Oral, ANAVEX2-73 Intravenous | NCT02244541 |
| Phase 2 | Completed | ANAVEX2-73 | NCT02756858 |
| Phase 2 | Completed | ANAVEX2-73, Placebo | NCT03758924 |
| Phase 2 | Completed | High dose ANAVEX2-73, Mid dose ANAVEX2-73 | NCT03774459 |
| Phase 2 | Completed | ANAVEX2-73 | NCT04575259 |
| Phase 2 | Active, not recruiting | ANAVEX3-71 oral capsules, Placebo oral capsules | NCT06245213 |
| Phase 1 | Completed | ANAVEX3-71, Placebo | NCT04442945 |