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ANAVEX LIFE SCIENCES CORP. (AVXL)

Operating as a clinical-stage biopharmaceutical entity, Anavex Life Sciences Corp. specializes in developing therapeutic drug candidates for various central nervous system (CNS) conditions. Its leading compound, ANAVEX 2-73, is currently in advanced development, undergoing Phase III clinical evaluation for both Alzheimer's disease and pediatric Rett syndrome. This same drug is also in Phase II trials for Parkinson's disease and is being explored in preclinical studies for a wider range of disorders, including epilepsy, infantile spasms, Fragile X syndrome, Angelman syndrome, multiple sclerosis, and tuberous sclerosis complex. Another significant drug candidate, ANAVEX 3-71, has progressed to Phase I clinical trials for frontotemporal dementia and other forms of dementia, with additional preclinical investigation underway for neurodegenerative illnesses like Alzheimer's and Parkinson's. The company's earlier-stage portfolio includes ANAVEX 1-41, a sigma-1 receptor agonist targeting depression, stroke, Parkinson's, and Alzheimer's diseases; ANAVEX 1066, a mixed sigma-1/sigma-2 ligand with potential applications in neuropathic and visceral pain; and ANAVEX 1037, aimed at treating prostate and pancreatic cancers. Anavex Life Sciences Corp. was founded in 2004 and maintains its headquarters in New York, New York.

Sector: Biological Products, (No Diagnostic Substances)

Industry: Biotechnology

Anavex Life Sciences Corp. logo

Anavex Life Sciences Corp.

NASDAQ:AVXLHealthcare
-8.46%$1.19
AH$1.22+2.52%vs close
Mkt Cap$110.31M
Float92.67M
O/S92.7M
Vol
$ Vol
RVOL
Inst Own39.6%
SI13.5%
Earnings
Dilution
Phase Distribution
11 lead-sponsored trials·1 active·10 completed
Phase 11
Phase 26
Phase 2/33
Phase 31
(2 more as collaborator)
Status Overview
Active, not recruiting1
Completed10

Trials need funding. See this company's dilution risk and cash position.

Clinical Trials
Sponsor role
Status
Phase
  • Phase 3
    Completed

    ANAVEX2-73 Study in Patients With Rett Syndrome

    ANAVEX2-73, Placebo

    Rett Syndrome

    Enrollment
    33
    Start
    May 2019
    Primary Completion
    Sep 2021
    Completion
    Sep 2021
    NCT03941444
  • Phase 2/3
    Completed

    ANAVEX2-73 for Treatment of Early Alzheimer's Disease

    High dose ANAVEX2-73, Mid dose ANAVEX2-73

    Alzheimer Disease

    Enrollment
    509
    Start
    Jul 2018
    Primary Completion
    Jun 2022
    Completion
    Jun 2022
    NCT03790709
  • Phase 2/3
    Completed

    ANAVEX2-73 Study in Pediatric Patients With Rett Syndrome

    ANAVEX2-73 oral liquid, Placebo oral liquid

    Rett Syndrome

    Enrollment
    92
    Start
    Jul 2020
    Primary Completion
    Jun 2023
    Completion
    Jun 2023
    NCT04304482
  • Phase 2/3
    Completed

    OLE of Phase 2b/3 Study ANAVEX2-73-AD-004

    ANAVEX2-73

    Alzheimer Disease

    Enrollment
    300
    Start
    Oct 2019
    Primary Completion
    Jun 2024
    Completion
    Jun 2024
    NCT04314934
  • Phase 2
    Completed

    Phase 2a Dose Finding, PK/PD and 12 Month Exploratory Efficacy Study of ANAVEX2-73 in Patients With Alzheimer's Disease

    ANAVEX2-73 Oral, ANAVEX2-73 Intravenous

    Alzheimer's Disease

    Enrollment
    32
    Start
    Dec 2014
    Primary Completion
    Nov 2015
    Completion
    Nov 2016
    NCT02244541
  • Phase 2
    Completed

    An Extension Study of ANAVEX2-73 in Patients With Mild to Moderate Alzheimer's Disease

    ANAVEX2-73

    Alzheimer's Disease

    Enrollment
    21
    Start
    Mar 2016
    Primary Completion
    Nov 2020
    Completion
    Nov 2020
    NCT02756858
  • Phase 2
    Completed

    Study of ANAVEX2-73 in Patients With Rett Syndrome

    ANAVEX2-73, Placebo

    Rett Syndrome

    Enrollment
    31
    Start
    Feb 2019
    Primary Completion
    Oct 2020
    Completion
    Oct 2020
    NCT03758924
  • Phase 2
    Completed

    ANAVEX2-73 Study in Parkinson's Disease Dementia

    High dose ANAVEX2-73, Mid dose ANAVEX2-73

    Parkinsons Disease With Dementia

    Enrollment
    132
    Start
    Jul 2018
    Primary Completion
    Sep 2020
    Completion
    Sep 2020
    NCT03774459
  • Phase 2
    Completed

    OLE Study for Patients With Parkinson's Disease With Dementia Enrolled in Study ANAVEX2-73-PDD-001

    ANAVEX2-73

    Parkinson Disease Dementia

    Enrollment
    132
    Start
    Oct 2019
    Primary Completion
    May 2022
    Completion
    Jun 2022
    NCT04575259
  • Phase 2
    Active, not recruiting

    A Study of ANAVEX3-71 in Adults With Schizophrenia

    ANAVEX3-71 oral capsules, Placebo oral capsules

    Schizophrenia

    Enrollment
    71
    Start
    Mar 2024
    Primary Completion
    Jun 2025est.
    Completion
    Jun 2025est.
    NCT06245213
  • Phase 1
    Completed

    Phase 1 Study of ANAVEX3-71

    ANAVEX3-71, Placebo

    Healthy

    Enrollment
    36
    Start
    Jul 2020
    Primary Completion
    Sep 2021
    Completion
    Oct 2021
    NCT04442945