Beam Therapeutics Inc. (BEAM)
Beam Therapeutics Inc., founded in 2017 and based in Cambridge, Massachusetts, operates as a pioneering biopharmaceutical firm. Its core mission involves engineering precise genetic remedies to tackle a spectrum of severe human ailments, primarily within the United States. The company's developmental portfolio features several key candidates: BEAM-101 is being advanced to treat both sickle cell disease and beta thalassemia. BEAM-102 is specifically designed for addressing sickle cell disease. BEAM-201, an allogeneic chimeric antigen receptor T-cell therapy, is under investigation for individuals suffering from relapsed or refractory T-cell acute lymphoblastic leukemia. BEAM-301 is a liver-targeted candidate aimed at patients afflicted with Glycogen Storage Disease Type Ia. Beyond these flagship programs, Beam Therapeutics is also engaged in devising treatments for alpha-1 antitrypsin deficiency, various ocular conditions, and other disorders impacting the liver, muscular system, and central nervous system. To further its research and development objectives, Beam Therapeutics has forged numerous strategic alliances and partnerships. These include collaborations with Boston Children's Hospital; a research and clinical trial agreement with Magenta Therapeutics, Inc.; a licensing deal with Sana Biotechnology, Inc.; and a research partnership with the Institute of Molecular and Clinical Ophthalmology Basel. Additionally, the company maintains research collaborations with both Pfizer Inc. and Apellis Pharmaceuticals, Inc., alongside a comprehensive collaboration and license agreement with Verve Therapeutics, Inc.
Sector: Biological Products, (No Diagnostic Substances)
Industry: Biotechnology
Beam Therapeutics Inc.
Trials need funding. See this company's dilution risk and cash position.
- Phase 1/2Active, not recruiting
BEACON: A Study Evaluating the Safety and Efficacy of BEAM-101 in Patients With Severe Sickle Cell Disease
BEAM-101
Sickle Cell Disease
NCT05456880Enrollment15StartAug 2022Primary CompletionFeb 2028est.CompletionFeb 2028est. - Phase 1/2Active, not recruiting
A Study Evaluating the Safety and Efficacy of BEAM-201 in Relapsed/Refractory T-Cell Acute Lymphoblastic Leukemia (T-ALL) or T-Cell Lymphoblastic Lymphoma (T-LL)
BEAM-201
Lymphoblastic Lymphoma, T-Cell Lymphoblastic Leukemia/Lymphoma +1
NCT05885464Enrollment5StartMay 2023Primary CompletionDec 2026est.CompletionDec 2026est. - Phase 1/2Recruiting
A Study to Evaluate the Safety and Efficacy of BEAM-302 in Adult Patients With Alpha-1 Antitrypsin Deficiency (AATD)
BEAM-302
Alpha 1-Antitrypsin Deficiency
NCT06389877Enrollment192StartJun 2024Primary CompletionMay 2028est.CompletionMay 2030est. - Phase 1/2Recruiting
A Phase 1/2, Dose-Exploration Study to Evaluate the Safety and Efficacy of BEAM-301 in Patients With Glycogen Storage Disease Type Ia (GSDIa)
BEAM-301: Single dose of BEAM-301 administered by IV
Glycogen Storage Disease Type Ia
NCT06735755Enrollment36StartDec 2024Primary CompletionDec 2027est.CompletionDec 2027est. - Phase 1Recruiting
This is a Phase 1, Randomized, Single-blind, Placebo-controlled Study to Assess the Safety, Pharmacokinetics (PK), and Pharmacodynamics (PD) of BEAM-103 in Healthy Subjects
BEAM-103, Placebo Comparator
Healthy Subjects, Healthy Participant Study
NCT07304791Enrollment30StartOct 2025Primary CompletionJan 2026est.CompletionMay 2026est. - Not applicableCompleted
An Exploratory Investigation of a Supplement to Enhance Sleep Quality and Quantity
Beam Organics Dream Powder, Beam Organics Dream Powder Extra Strength
Sleep, Sleep Disturbance +1
NCT05521243Enrollment64StartMay 2022Primary CompletionSep 2022CompletionSep 2022 - Not applicableCompleted
A Crossover Trial to Examine the Efficacy of a Powder to Improve Sleep Quality and Performance
BEAM Dream Powder, Placebo Control
Sleep, Sleep Disorder
NCT07183735Enrollment40StartJul 2024Primary CompletionOct 2024CompletionOct 2024 - ObservationalRecruiting
A Long-term Follow-up Study in Patients Who Received BEAM-101
Long-Term Follow-up Study of patients who received BEAM-101
Hemoglobinopathy, Sickle Cell Disease
NCT07373639Enrollment50StartDec 2025Primary CompletionFeb 2043est.CompletionFeb 2043est.
| Drug / Therapy | Link | ||
|---|---|---|---|
| Phase 1/2 | Active, not recruiting | BEAM-101 | NCT05456880 |
| Phase 1/2 | Active, not recruiting | BEAM-201 | NCT05885464 |
| Phase 1/2 | Recruiting | BEAM-302 | NCT06389877 |
| Phase 1/2 | Recruiting | BEAM-301: Single dose of BEAM-301 administered by IV | NCT06735755 |
| Phase 1 | Recruiting | BEAM-103, Placebo Comparator | NCT07304791 |
| Not applicable | Completed | Beam Organics Dream Powder, Beam Organics Dream Powder Extra Strength | NCT05521243 |
| Not applicable | Completed | BEAM Dream Powder, Placebo Control | NCT07183735 |
| Observational | Recruiting | Long-Term Follow-up Study of patients who received BEAM-101 | NCT07373639 |