Denali Therapeutics Inc. (DNLI)
Denali Therapeutics Inc. is a biopharmaceutical firm, founded in 2013 and based in South San Francisco, California, which focuses on identifying and advancing treatments for neurodegenerative conditions within the United States. The company, initially known as SPR Pharma Inc. until its renaming in March 2015, possesses a robust development pipeline. This includes BIIB122/DNL151, a small molecule inhibitor targeting leucine-rich repeat kinase 2 (LRRK2), currently in Phase 1 and Phase 1b clinical trials for Parkinson's disease. Another candidate, DNL310, is progressing through Phase 1/2 clinical studies for Hunter syndrome. For amyotrophic lateral sclerosis (ALS), DNL343 is in Phase 1 trials, while AR443820/DNL788 has successfully concluded its Phase 1 clinical trial for ALS, multiple sclerosis (MS), and Alzheimer's disease. Furthermore, SAR443122/DNL758 is undergoing Phase 2 clinical trials for cutaneous lupus erythematosus. Denali Therapeutics is engaged in extensive collaborative efforts with a range of partners, including Takeda Pharmaceutical Company, Genentech, Inc., Sanofi, F-star Gamma Limited, F-star Biotechnologische Forschungs-Und Entwicklungsges M.B.H, F-star Biotechnology Limited, SIRION Biotech GmbH, Genzyme Corporation, Harvard University, the Michael J. Fox Foundation, and Centogene. It also maintains a research and option agreement with Secarna Pharmaceuticals GmbH & Co. KG to co-develop antisense therapies specifically for neurodegenerative diseases.
Sector: Biological Products, (No Diagnostic Substances)
Industry: Biotechnology
Denali Therapeutics Inc.
NASDAQ:DNLIHealthcare · Biotechnology
-1.97%$18.94
AH$19.00+0.32%vs close
Mkt Cap$3.03B
Float133.14M
O/S159.85M
Vol
$ Vol
RVOL
Inst Own97.8%
SI11.6%
Earnings
Dilution
Financials Summary
Revenue$0
Net Income-$512.54M
Total Assets$1.14B
Free Cash Flow-$422.1M
Debt & Equity
Debt 3%
Equity 97%
Total Debt$36.76M
Total Equity$1.01B
Shares Outstanding
Short Interest
Split History
No splits on record
Nothing in DNLI's public trading history: no forward or reverse split has affected the share count.
Balance Sheet Details
Assets$1.14B
Liabilities$131.09M
Accounts Receivable$2.18M
Accounts Payable$3.33M
Inventory$0
PP&E (Net)$119.94M
Goodwill$0
Intangible Assets$0
Income Statement
| Period | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 | FY 2015 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Currency | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD |
| Period Ending | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | 2020-12-31 | 2019-12-31 | 2018-12-31 | 2017-12-31 | 2016-12-31 | 2015-12-31 |
| Revenue | $0 | $0 | $330.53M | $108.46M | $48.66M | $335.66M | $26.68M | $129.16M | $0 | $0 | $0 |
| YoY Growth | - | - | 204.7% | 122.9% | -85.5% | 1158.2% | -79.3% | - | - | - | - |
| Cost of Revenue | $11.18M | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $3.08M | $1.47M | $121K |
| Gross Profit | -$11.18M | $0 | $330.53M | $108.46M | $48.66M | $335.66M | $26.68M | $129.16M | -$3.08M | -$1.47M | -$121K |
| Gross Margin | - | - | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% | - | - | - |
| Research and Development | $418.78M | $396.44M | $423.88M | $358.73M | $265.35M | $212.62M | $193.38M | $143.18M | $74.46M | $75.7M | $11.57M |
| Selling, General, and Administrative | $97.1M | $105.44M | $103.35M | $90.47M | $79.06M | $60.33M | $46.48M | $32.35M | $15.68M | $11.73M | $5.11M |
| Other | $28.28M | -$14.54M | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Total Operating Expenses | $544.16M | $487.34M | $527.23M | $449.21M | $344.41M | $272.94M | $239.86M | $175.53M | $90.14M | $87.43M | $16.68M |
| Operating Income (EBIT) | -$555.34M | -$487.34M | -$196.7M | -$340.74M | -$295.75M | $62.72M | -$213.18M | -$46.37M | -$90.14M | -$87.43M | -$16.68M |
| Operating Margin | - | - | -59.5% | -314.2% | -607.8% | 18.7% | -799.1% | -35.9% | - | - | - |
| Interest Expense | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $1.96M | $0 | $109K |
| Interest Income | $42.9M | $64.64M | $51.51M | $14.77M | $4.59M | $9.24M | $15.22M | $10.13M | $1.96M | $781K | $0 |
| Other Income (Expense) | $42.9M | $64.64M | $51.51M | $14.77M | $4.59M | $9.24M | $15.22M | $10.13M | $1.96M | $781K | -$109K |
| Income Before Tax (EBT) | -$512.44M | -$422.7M | -$145.19M | -$325.97M | -$291.16M | $71.96M | -$197.97M | -$36.24M | -$88.19M | -$86.65M | -$16.79M |
| Income Tax Expense | $102K | $68K | $30K | $21K | -$575K | $823K | -$351K | $0 | $0 | $0 | $0 |
| Net Income | -$512.54M | -$422.77M | -$145.22M | -$325.99M | -$290.58M | $71.14M | -$197.61M | -$36.24M | -$88.19M | -$86.65M | -$16.79M |
| Net Income Margin | - | - | -43.9% | -300.6% | -597.2% | 21.2% | -740.7% | -28.1% | - | - | - |
| Supplementary Data | |||||||||||
| EPS | -2.97 | -2.57 | -1.06 | -2.60 | -2.39 | 0.65 | -2.07 | -0.39 | -5.89 | -13.49 | -5.58 |
| Diluted EPS | -2.97 | -2.57 | -1.06 | -2.60 | -2.39 | 0.63 | -2.07 | -0.39 | -5.89 | -13.49 | -5.58 |
| Weighted Average OS | 175.46M | 164.47M | 137.37M | 125.53M | 121.52M | 108.97M | 95.61M | 92.62M | 14.96M | 6.42M | 3.01M |
| EBITDA | -$497.63M | -$492.89M | -$128.47M | -$315.59M | -$282.56M | $71.25M | -$205.19M | -$38.96M | -$87.06M | -$85.96M | -$15.06M |
| EBITDA Margin | - | - | -38.9% | -291.0% | -580.7% | 21.2% | -769.1% | -30.2% | - | - | - |
Balance Sheet
| Period | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 | FY 2015 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Currency | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD |
| Period Ending | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | 2020-12-31 | 2019-12-31 | 2018-12-31 | 2017-12-31 | 2016-12-31 | 2015-12-31 |
| Assets | |||||||||||
| Current Assets | |||||||||||
| Cash and Cash Equivalents | $205.33M | $174.96M | $127.11M | $218.04M | $293.48M | $507.14M | $79.45M | $77.12M | $218.38M | $39.85M | $30.74M |
| Short-Term Investments | $662.55M | $657.37M | $907.4M | $1.12B | $571.93M | $962.55M | $335.91M | $387.17M | $187.85M | $138.48M | $0 |
| Cash and Short-Term Investments | $867.88M | $832.33M | $1.03B | $1.34B | $865.41M | $1.47B | $415.36M | $464.3M | $406.23M | $178.33M | $30.74M |
| Accounts Receivable | $2.18M | $2.17M | $3.42M | $9.28M | $1.23M | $0 | $0 | $8.55M | $464K | $438K | $0 |
| Inventory | $0 | $0 | $0 | $0 | $0 | $0 | $0 | -$8.55M | -$464K | $0 | $0 |
| Other Current Assets | $30.6M | $0 | $0 | $0 | $0 | $25.96M | $0 | $1.35M | $0 | $0 | $0 |
| Total Current Assets | $900.66M | $864.44M | $1.06B | $1.37B | $897.23M | $1.5B | $430.03M | $480.84M | $409.61M | $181.96M | $33.43M |
| Long-Term Assets | |||||||||||
| Property, Plant & Equipment Net | $119.94M | $125.63M | $71.64M | $74.52M | $69.61M | $73.46M | $80.66M | $25.16M | $14.92M | $15.26M | $3.17M |
| Goodwill | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Intangible Assets | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Long-Term Investments | $98.32M | $359.37M | $0 | $1.5M | $425.45M | $34.2M | $39.89M | $147.88M | $60.75M | $73.08M | $84K |
| Deferred Tax Assets | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Other Long-Term Assets | $25.94M | $24.74M | $18.14M | $11.9M | $11.87M | $962K | $2.66M | $8.11M | $1.44M | $770K | $0 |
| Total Long-Term Assets | $244.2M | $509.74M | $89.78M | $87.92M | $506.93M | $108.63M | $123.2M | $181.15M | $77.11M | $89.11M | $3.25M |
| Other Assets | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Total Assets | $1.14B | $1.37B | $1.15B | $1.46B | $1.4B | $1.6B | $553.23M | $661.98M | $486.72M | $271.07M | $36.68M |
| Liabilities | |||||||||||
| Current Liabilities | |||||||||||
| Accounts Payable | $3.33M | $11.14M | $9.48M | $2.79M | $4.78M | $1.07M | $2.59M | $1.89M | $2.72M | $1.96M | $1.71M |
| Short-Term Debt | $0 | $0 | $0 | $0 | $0 | $4.69M | $0 | $0 | $0 | $0 | $0 |
| Current Income Tax Payable | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Current Unearned Revenue | $0 | $0 | $0 | $290.05M | $320.3M | $23.48M | $18.74M | $11.43M | $0 | $0 | $0 |
| Other Current Liabilities | $53.28M | $38.86M | $21.59M | $17.09M | $19.01M | $21.95M | $8.74M | $9.52M | $918K | $701K | $148K |
| Total Current Liabilities | $98.35M | $102.21M | $77.98M | $363.92M | $378.25M | $71.7M | $45.34M | $32.79M | $14.16M | $9.11M | $3.48M |
| Long-Term Liabilities | |||||||||||
| Long-Term Debt | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Long-Term Unearned Revenue | $0 | $0 | $0 | $479K | $4.69M | $317.17M | $43.75M | $57.35M | $0 | $0 | $0 |
| Long-Term Deferred Tax Liabilities | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Other Long-Term Liabilities | $5.53M | $5.62M | $0 | $379K | $379K | $701K | $379K | $25M | $6.76M | $7.44M | $48.84M |
| Total Long-Term Liabilities | $32.74M | $42.29M | $44.98M | $53.89M | $63.63M | $382.05M | $113M | $82.35M | $6.76M | $7.44M | $48.84M |
| Other Liabilities | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Total Liabilities | $131.09M | $144.5M | $122.96M | $417.81M | $441.87M | $453.75M | $158.34M | $115.14M | $20.93M | $16.55M | $52.32M |
| Stockholders' Equity | |||||||||||
| Preferred Stock | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $348.67M | $48.31M |
| Common Stock | $1.89M | $1.77M | $1.71M | $1.69M | $1.55M | $1.53M | $1.29M | $1.27M | $1.2M | $2.69M | $170K |
| Retained Earnings | -$2.05B | -$1.54B | -$1.12B | -$970.99M | -$645M | -$354.42M | -$425.55M | -$227.94M | -$191.7M | -$103.51M | -$16.86M |
| Comprehensive Income & Other | $682K | $2.02M | $643K | -$6.89M | -$2.5M | -$245K | $350K | -$649K | -$368K | -$373K | -$48.31M |
| Other Stockholders' Equity | $3.06B | $2.77B | $2.15B | $2.01B | $1.61B | $1.5B | $819.15M | $773.51M | $656.29M | $355.34M | $1.06M |
| Total Equity | $1.01B | $1.23B | $1.03B | $1.04B | $962.29M | $1.15B | $394.89M | $546.85M | $465.8M | $254.52M | -$15.63M |
| Minority Interest | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Total Liabilities and Equity | $1.14B | $1.37B | $1.15B | $1.46B | $1.4B | $1.6B | $553.23M | $661.98M | $486.72M | $271.07M | $36.68M |
| Supplementary Data | |||||||||||
| Total Debt | $36.76M | $48.71M | $52.24M | $60.35M | $64.01M | $68.86M | $72.53M | $0 | $0 | $0 | $0 |
| Net Debt | -$168.57M | -$126.25M | -$74.86M | -$157.69M | -$229.47M | -$438.28M | -$6.92M | -$77.12M | -$218.38M | -$39.85M | -$30.74M |
Cash Flow Statement
| Period | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 | FY 2015 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Currency | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD |
| Period Ending | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | 2020-12-31 | 2019-12-31 | 2018-12-31 | 2017-12-31 | 2016-12-31 | 2015-12-31 |
| Operating Activities | |||||||||||
| Net Income | -$512.54M | -$422.77M | -$145.22M | -$325.99M | -$290.58M | $71.14M | -$197.61M | -$36.24M | -$88.19M | -$86.65M | -$16.79M |
| Depreciation & Amortization | $14.81M | $8.99M | $16.73M | $10.38M | $8.59M | $8.53M | $7.99M | $7.42M | $3.08M | $1.47M | $121K |
| Deferred Income Tax | $0 | $0 | $0 | $0 | $0 | $55K | $0 | $0 | $0 | $307K | $0 |
| Stock-Based Compensation | $99.63M | $102.88M | $108.1M | $99.85M | $85.25M | $50.35M | $38.38M | $18.79M | $4.41M | $2.95M | $479K |
| Changes in Working Capital: | |||||||||||
| Accounts Receivable | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Inventory | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Accounts Payable | -$7.52M | $1.44M | $2.43M | $2.27M | $3.71M | -$1.62M | $1.03M | -$526K | $207K | $161K | $1.68M |
| Other Working Capital | $7.67M | $15.5M | -$292.36M | -$26.3M | -$24.12M | $290.02M | $1.89M | $63.42M | $3.1M | $4.13M | -$1.25M |
| Total Working Capital Change | $149K | $16.94M | -$289.93M | -$24.03M | -$20.41M | $288.4M | $2.92M | $62.89M | $3.31M | $4.29M | $426K |
| Other Non-Cash Items | -$14.65M | -$53.73M | -$47.67M | -$4.92M | $5.76M | -$2.32M | -$3.25M | -$2.74M | $754K | $5.28M | $710K |
| Net Cash from Operating | -$412.6M | -$347.69M | -$357.99M | -$244.72M | -$211.39M | $416.15M | -$151.58M | $50.12M | -$76.64M | -$72.36M | -$15.05M |
| Investing Activities | |||||||||||
| Capital Expenditures | -$9.5M | -$15.91M | -$12.94M | -$17.83M | -$8.5M | -$3.1M | -$17.92M | -$3.39M | -$2.88M | -$6.13M | -$3.06M |
| Acquisitions | $0 | $0 | $0 | $123.55M | $0 | $620.11M | $0 | $0 | $0 | $0 | $0 |
| Purchases of Investments | -$441.26M | -$1.23B | -$1.81B | -$1.12B | -$1.42B | -$1.29B | -$369.7M | -$557.93M | -$179.79M | -$226.87M | $0 |
| Sales of Investments | $706.05M | $1.16B | $2.08B | $991.49M | $1.41B | $665.36M | $535.33M | $273.9M | $141.5M | $14M | $0 |
| Other Investing Activities | $0 | $0 | $0 | -$123.55M | $0 | -$620.11M | $0 | -$284.03M | -$38.29M | -$212.87M | $0 |
| Net Cash from Investing | $255.28M | -$88.76M | $249.31M | -$141.39M | -$21.63M | -$623.21M | $147.71M | -$287.42M | -$41.17M | -$219M | -$3.06M |
| Financing Activities | |||||||||||
| Debt Repaid | $8.17M | $32.34M | - | - | - | - | - | - | - | - | -$5M |
| Common Stock Issuance | $197.38M | $499.25M | $17.82M | $296.21M | $19.35M | $614.09M | $0 | $94.41M | $265.62M | $300.48M | $110K |
| Common Stock Repurchases | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Dividends Paid | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Other Financing Activities | $0 | $17.39M | $0 | $14.46M | $0 | $20.66M | $6.19M | $2.61M | $733K | $111K | $510K |
| Net Cash from Financing | $189.22M | $484.3M | $17.82M | $310.67M | $19.35M | $634.75M | $6.19M | $97.02M | $296.32M | $300.48M | $48.85M |
| Forex Effect | $0 | $0 | -$75K | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Net Change in Cash | $31.9M | $47.85M | -$90.94M | -$75.43M | -$213.67M | $427.69M | $2.33M | -$140.29M | $178.52M | $9.11M | $30.74M |
| Supplementary Data | |||||||||||
| Operating Cash Flow | -$412.6M | -$347.69M | -$357.99M | -$244.72M | -$211.39M | $416.15M | -$151.58M | $50.12M | -$76.64M | -$72.36M | -$15.05M |
| Capital Expenditure | -$9.5M | -$15.91M | -$12.94M | -$17.83M | -$8.5M | -$3.1M | -$17.92M | -$3.39M | -$2.88M | -$6.13M | -$3.06M |
| Free Cash Flow | -$422.1M | -$363.61M | -$370.93M | -$262.55M | -$219.89M | $413.06M | -$169.5M | $46.72M | -$79.51M | -$78.49M | -$18.11M |
| Cash at Beginning | $176.53M | $128.68M | $218.04M | $294.98M | $508.64M | $80.95M | $78.62M | $218.91M | $39.85M | $30.74M | $0 |
| Cash at End | $208.43M | $176.53M | $127.11M | $219.54M | $294.98M | $508.64M | $80.95M | $78.62M | $218.38M | $39.85M | $30.74M |