Generate Biomedicines, Inc. (GENB)
Generate Biomedicines, Inc. is a U.S.-based company pioneering generative biology, leveraging machine learning for the discovery and advancement of novel protein therapeutics. Their core approach involves developing drugs using protein-based modalities. The company's pipeline includes several key candidates: GB-0895, an investigational long-acting anti-TSLP monoclonal antibody designed for bi-annual dosing in severe asthma; GB-4362, an MMAE payload neutralizer monoclonal antibody; and GB-5267, a MUC16 CAR-T cell therapy. Integral to their work is the Generate Platform, a sophisticated system engineered to be versatile across diverse therapeutic areas and protein modalities. This platform combines computational innovation with scalable biohardware, allowing them to tackle therapeutic hurdles beyond the capabilities of traditional technologies. Established in 2018, the company was initially known as Generate Biologics, Inc. before rebranding to Generate Biomedicines, Inc. in February 2020. Its headquarters are located in Somerville, Massachusetts.
Sector: Pharmaceutical Preparations
Industry: Biotechnology
Generate Biomedicines, Inc.
Trials need funding. See this company's dilution risk and cash position.
- Phase 3Recruiting
A Study to Investigate GB-0895 Adjunctive Therapy in Adults and Adolescents With Severe Uncontrolled Asthma (SOLAIRIA-1)
GB-0895, Placebo
Severe Asthma
NCT07276724Enrollment786StartDec 2025Primary CompletionDec 2028est.CompletionDec 2028est. - Phase 3Recruiting
A Study to Investigate GB-0895 Adjunctive Therapy in Adults and Adolescents With Severe Uncontrolled Asthma (SOLAIRIA-2)
GB-0895, Placebo
Severe Asthma
NCT07359846Enrollment786StartJan 2026Primary CompletionJan 2029est.CompletionJan 2029est. - Phase 1Active, not recruiting
Study to Investigate the Safety, Tolerability, and Pharmacokinetics of GB-7624 in Healthy Adult Participants
GB-7624, Placebo
Atopic Dermatitis (AD)
NCT06920693Enrollment40StartMar 2025Primary CompletionAug 2026est.CompletionDec 2026est. - Phase 1Completed
Study to Investigate the Safety, Tolerability, and Pharmacokinetics of GB-0669 in Healthy Adult Participants
GB-0669, Placebo
SARS CoV-2
NCT07050511Enrollment51StartJul 2023Primary CompletionNov 2024CompletionNov 2024 - Phase 1Active, not recruiting
A Study to Investigate GB-0895 in Adults With Mild to Moderate Asthma or COPD
GB-0895 (SC), GB-0895 (SC)
Asthma, COPD (Chronic Obstructive Pulmonary Disease)
NCT07116889Enrollment156StartDec 2023Primary CompletionMay 2027est.CompletionMay 2027est. - Phase 1Recruiting
Study of GB-4362 With Enfortumab Vedotin and Pembrolizumab for Advanced Urothelial Cancer
GB-4362, enfortumab vedotin (EV)
Advanced Urothelial Cancer, Metastatic Urothelial Carcinoma
NCT07484022Enrollment37StartJun 2026Primary CompletionJun 2027est.CompletionDec 2027est.
| Drug / Therapy | Link | ||
|---|---|---|---|
| Phase 3 | Recruiting | GB-0895, Placebo | NCT07276724 |
| Phase 3 | Recruiting | GB-0895, Placebo | NCT07359846 |
| Phase 1 | Active, not recruiting | GB-7624, Placebo | NCT06920693 |
| Phase 1 | Completed | GB-0669, Placebo | NCT07050511 |
| Phase 1 | Active, not recruiting | GB-0895 (SC), GB-0895 (SC) | NCT07116889 |
| Phase 1 | Recruiting | GB-4362, enfortumab vedotin (EV) | NCT07484022 |