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Generate Biomedicines, Inc. (GENB)

Generate Biomedicines, Inc. is a U.S.-based company pioneering generative biology, leveraging machine learning for the discovery and advancement of novel protein therapeutics. Their core approach involves developing drugs using protein-based modalities. The company's pipeline includes several key candidates: GB-0895, an investigational long-acting anti-TSLP monoclonal antibody designed for bi-annual dosing in severe asthma; GB-4362, an MMAE payload neutralizer monoclonal antibody; and GB-5267, a MUC16 CAR-T cell therapy. Integral to their work is the Generate Platform, a sophisticated system engineered to be versatile across diverse therapeutic areas and protein modalities. This platform combines computational innovation with scalable biohardware, allowing them to tackle therapeutic hurdles beyond the capabilities of traditional technologies. Established in 2018, the company was initially known as Generate Biologics, Inc. before rebranding to Generate Biomedicines, Inc. in February 2020. Its headquarters are located in Somerville, Massachusetts.

Sector: Pharmaceutical Preparations

Industry: Biotechnology

Generate Biomedicines, Inc. logo

Generate Biomedicines, Inc.

NASDAQ:GENBFinancial Services
-8.31%$14.46
AH$14.49+0.21%vs close
Mkt Cap$1.86B
Float57.89M
O/S128.35M
Vol
$ Vol
RVOL
Inst Own79.5%
SI15.4%
Earnings
Dilution
Phase Distribution
6 lead-sponsored trials·5 active·1 completed
Phase 14
Phase 32
(1 more as collaborator)
Status Overview
Recruiting3
Active, not recruiting2
Completed1

Trials need funding. See this company's dilution risk and cash position.

Clinical Trials
Sponsor role
Status
Phase
  • Phase 3
    Recruiting

    A Study to Investigate GB-0895 Adjunctive Therapy in Adults and Adolescents With Severe Uncontrolled Asthma (SOLAIRIA-1)

    GB-0895, Placebo

    Severe Asthma

    Enrollment
    786
    Start
    Dec 2025
    Primary Completion
    Dec 2028est.
    Completion
    Dec 2028est.
    NCT07276724
  • Phase 3
    Recruiting

    A Study to Investigate GB-0895 Adjunctive Therapy in Adults and Adolescents With Severe Uncontrolled Asthma (SOLAIRIA-2)

    GB-0895, Placebo

    Severe Asthma

    Enrollment
    786
    Start
    Jan 2026
    Primary Completion
    Jan 2029est.
    Completion
    Jan 2029est.
    NCT07359846
  • Phase 1
    Active, not recruiting

    Study to Investigate the Safety, Tolerability, and Pharmacokinetics of GB-7624 in Healthy Adult Participants

    GB-7624, Placebo

    Atopic Dermatitis (AD)

    Enrollment
    40
    Start
    Mar 2025
    Primary Completion
    Aug 2026est.
    Completion
    Dec 2026est.
    NCT06920693
  • Phase 1
    Completed

    Study to Investigate the Safety, Tolerability, and Pharmacokinetics of GB-0669 in Healthy Adult Participants

    GB-0669, Placebo

    SARS CoV-2

    Enrollment
    51
    Start
    Jul 2023
    Primary Completion
    Nov 2024
    Completion
    Nov 2024
    NCT07050511
  • Phase 1
    Active, not recruiting

    A Study to Investigate GB-0895 in Adults With Mild to Moderate Asthma or COPD

    GB-0895 (SC), GB-0895 (SC)

    Asthma, COPD (Chronic Obstructive Pulmonary Disease)

    Enrollment
    156
    Start
    Dec 2023
    Primary Completion
    May 2027est.
    Completion
    May 2027est.
    NCT07116889
  • Phase 1
    Recruiting

    Study of GB-4362 With Enfortumab Vedotin and Pembrolizumab for Advanced Urothelial Cancer

    GB-4362, enfortumab vedotin (EV)

    Advanced Urothelial Cancer, Metastatic Urothelial Carcinoma

    Enrollment
    37
    Start
    Jun 2026
    Primary Completion
    Jun 2027est.
    Completion
    Dec 2027est.
    NCT07484022