Legend Biotech Corp (LEGN)
Legend Biotech Corporation, through its subsidiaries, operates as a biopharmaceutical company that discovers, develops, manufactures, and commercializes novel cell therapies for oncology and other indications in the United States, China, and Europe. Its lead product candidate is ciltacabtagene autoleucel, or cilta-cel, which is a chimeric antigen receptor (CAR-T) therapy for the treatment of multiple myeloma (MM). The company also has a portfolio of earlier-stage autologous CAR-T product candidates targeting various cancers, including acute lymphoblastic leukemia, gastric cancer, esophageal cancer, pancreatic cancer, colorectal cancer, small cell lung cancer, and non-small cell lung cancer. In addition, it develops allogeneic gamma delta CAR-T and allogeneic CAR-NK product candidates targeting B-cell maturation antigen (BCMA) for MM, which are in investigator-initiated Phase 1 clinical trials in China. The company has a collaboration and license agreement with Janssen Biotech, Inc. for the development and commercialization of cilta-cel, as well as a license agreement with Novartis Pharma AG for the development, manufacture, and commercialization of CAR-T cell therapies targeting delta-like ligand protein 3. Legend Biotech Corporation was founded in 2014 and is headquartered in Somerset, New Jersey.
Sector: Pharmaceutical Preparations
Industry: Biotechnology
Legend Biotech Corporation
Trials need funding. See this company's dilution risk and cash position.
- Phase 1Unknown status
Study of CD4-Targeted Chimeric Antigen Receptor T-Cells (CD4- CAR-T) in Subjects With Relapsed or Refractory T-Cell Lymphoma
LB1901
T-Cell Lymphoma, Peripheral T-Cell Lymphoma Refractory +3
NCT04712864Enrollment50StartSep 2021Primary CompletionDec 2023est.CompletionDec 2025est. - Phase 1Active, not recruiting
Claudin 18.2-Targeted Chimeric Antigen Receptor T-cells in Subjects With Unresectable, Locally Advanced, or Metastatic Gastric, Gastroesophageal Junction (GEJ), Esophageal, or Pancreatic Adenocarcinoma
LB1908
Gastric Cancer, Gastroesophageal-junction Cancer +2
NCT05539430Enrollment56StartApr 2023Primary CompletionDec 2027est.CompletionDec 2027est. - Phase 1Active, not recruiting
DLL3-Directed Chimeric Antigen Receptor T-cells in Subjects With Extensive Stage Small Cell Lung Cancer
LB2102
Small Cell Lung Cancer Extensive Stage, Large Cell Neuroendocrine Carcinoma of the Lung
NCT05680922Enrollment41StartJul 2023Primary CompletionDec 2027est.CompletionDec 2027est.
| Drug / Therapy | Link | ||
|---|---|---|---|
| Phase 1 | Unknown status | LB1901 | NCT04712864 |
| Phase 1 | Active, not recruiting | LB1908 | NCT05539430 |
| Phase 1 | Active, not recruiting | LB2102 | NCT05680922 |