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Legend Biotech Corp (LEGN)

Legend Biotech Corporation, through its subsidiaries, operates as a biopharmaceutical company that discovers, develops, manufactures, and commercializes novel cell therapies for oncology and other indications in the United States, China, and Europe. Its lead product candidate is ciltacabtagene autoleucel, or cilta-cel, which is a chimeric antigen receptor (CAR-T) therapy for the treatment of multiple myeloma (MM). The company also has a portfolio of earlier-stage autologous CAR-T product candidates targeting various cancers, including acute lymphoblastic leukemia, gastric cancer, esophageal cancer, pancreatic cancer, colorectal cancer, small cell lung cancer, and non-small cell lung cancer. In addition, it develops allogeneic gamma delta CAR-T and allogeneic CAR-NK product candidates targeting B-cell maturation antigen (BCMA) for MM, which are in investigator-initiated Phase 1 clinical trials in China. The company has a collaboration and license agreement with Janssen Biotech, Inc. for the development and commercialization of cilta-cel, as well as a license agreement with Novartis Pharma AG for the development, manufacture, and commercialization of CAR-T cell therapies targeting delta-like ligand protein 3. Legend Biotech Corporation was founded in 2014 and is headquartered in Somerset, New Jersey.

Sector: Pharmaceutical Preparations

Industry: Biotechnology

Legend Biotech Corporation logo

Legend Biotech Corporation

NASDAQ:LEGNHealthcare
-3.00%$21.63
AH$21.74+0.51%vs close
Mkt Cap$4.21B
Float162.91M
O/S194.49M
Vol
$ Vol
RVOL
Inst Own52.0%
SI8.5%
Earnings
Dilution
Pipeline3 lead-sponsored trials·2 active0 completed(1 more as collaborator)

Trials need funding. See this company's dilution risk and cash position.

Clinical Trials
Sponsor role
Status
  • Phase 1
    Unknown status

    Study of CD4-Targeted Chimeric Antigen Receptor T-Cells (CD4- CAR-T) in Subjects With Relapsed or Refractory T-Cell Lymphoma

    LB1901

    T-Cell Lymphoma, Peripheral T-Cell Lymphoma Refractory +3

    Enrollment
    50
    Start
    Sep 2021
    Primary Completion
    Dec 2023est.
    Completion
    Dec 2025est.
    NCT04712864
  • Phase 1
    Active, not recruiting

    Claudin 18.2-Targeted Chimeric Antigen Receptor T-cells in Subjects With Unresectable, Locally Advanced, or Metastatic Gastric, Gastroesophageal Junction (GEJ), Esophageal, or Pancreatic Adenocarcinoma

    LB1908

    Gastric Cancer, Gastroesophageal-junction Cancer +2

    Enrollment
    56
    Start
    Apr 2023
    Primary Completion
    Dec 2027est.
    Completion
    Dec 2027est.
    NCT05539430
  • Phase 1
    Active, not recruiting

    DLL3-Directed Chimeric Antigen Receptor T-cells in Subjects With Extensive Stage Small Cell Lung Cancer

    LB2102

    Small Cell Lung Cancer Extensive Stage, Large Cell Neuroendocrine Carcinoma of the Lung

    Enrollment
    41
    Start
    Jul 2023
    Primary Completion
    Dec 2027est.
    Completion
    Dec 2027est.
    NCT05680922