Marker Therapeutics, Inc. (MRKR)
Marker Therapeutics, Inc. is a clinical-stage immuno-oncology company focused on discovering and bringing to market a variety of T cell-based immunotherapies and peptide-based vaccines. These cutting-edge treatments are engineered to address both blood cancers (hematological malignancies) and solid tumor conditions across the United States. A cornerstone of their approach is the proprietary MultiTAA-specific T cell technology. This method involves producing T cells that are not genetically modified but are specifically designed to target tumors. These specialized T cells can identify multiple antigens associated with tumors, allowing them to effectively eliminate cancer cells that express these markers. Marker Therapeutics' MultiTAA-specific T cell therapies encompass patient-derived (autologous) T cells for treating lymphoma and various solid tumors, as well as donor-derived (allogeneic) T cells for acute myeloid leukemia and acute lymphoblastic leukemia. They also provide "off-the-shelf" solutions applicable to a range of diseases. In addition to T cell therapies, the company is advancing peptide-based immunotherapeutic vaccines. This pipeline includes TPIV100/110, developed to combat breast and ovarian cancer cells, and TPIV200, which is currently undergoing Phase 2 clinical trials for the treatment of breast and ovarian cancers. Founded in 1999, Marker Therapeutics maintains its headquarters in Houston, Texas.
Sector: Pharmaceutical Preparations
Industry: Biotechnology
Marker Therapeutics, Inc.
Trials need funding. See this company's dilution risk and cash position.
- Phase 2Completed
Folate Receptor Alpha Peptide Vaccine With GM-CSF in Patients With Triple Negative Breast Cancer
Low dose FRα vaccine, Cyclophosphamide
Breast Cancer
NCT02593227Enrollment80StartApr 2016Primary CompletionJul 2021CompletionJul 2021 - Phase 2Terminated
Folate Receptor Alpha Peptide Vaccine With GM-CSF Versus GM-CSF Alone in Patients With Platinum Sensitive Ovarian Cancer
FRα peptide plus Adjuvant (GM-CSF), Adjuvant (GM-CSF) Alone
Platinum Sensitive Ovarian Cancer, Ovarian Cancer
NCT02978222Enrollment120StartJul 2017Primary CompletionJan 2020CompletionJan 2020 - Phase 2Terminated
Efficacy of MT-401 in Patients With AML Following Stem Cell Transplant
MT-401
Acute Myeloid Leukemia, Stem Cell Transplantation
NCT04511130Enrollment92StartOct 2020Primary CompletionMar 2024CompletionMar 2024 - Phase 1Recruiting
Safety and Preliminary Efficacy of MT-601 in Patients With Relapsed/Refractory Lymphoma
MT-601
Non-Hodgkin Lymphoma, Adult, Non-Hodgkin Lymphoma, Refractory +5
NCT05798897Enrollment79StartJan 2023Primary CompletionFeb 2028est.CompletionFeb 2028est. - Phase 1Not yet recruiting
MT-601 Administered To Patients With Locally Advanced Unresectable or Metastatic Pancreatic Cancer
MT-601 dose 200 million cells, MT-601 dose 400 million cells
Pancreas Cancer, Pancreatic Cancer Metastatic +1
NCT06549751Enrollment38StartJul 2026est.Primary CompletionJul 2028est.CompletionSep 2028est. - Phase 1Recruiting
Safety of MT-401-OTS in Patients With Relapsed AML or MDS
MT-401-OTS
Acute Myeloid Leukemia, in Relapse, MDS
NCT06552416Enrollment40StartJun 2025Primary CompletionSep 2029est.CompletionSep 2029est. - Not applicableCompleted
Plasma Adsorption in Patients With Confirmed COVID-19
Marker Therapeutics D2000 Cartridge (D2000) for use with the Spectra Optia® Apheresis System (Optia SPD Protocol)
Respiratory Failure, ARDS
NCT04358003Enrollment107StartMay 2020Primary CompletionNov 2021CompletionApr 2022
| Drug / Therapy | Link | ||
|---|---|---|---|
| Phase 2 | Completed | Low dose FRα vaccine, Cyclophosphamide | NCT02593227 |
| Phase 2 | Terminated | FRα peptide plus Adjuvant (GM-CSF), Adjuvant (GM-CSF) Alone | NCT02978222 |
| Phase 2 | Terminated | MT-401 | NCT04511130 |
| Phase 1 | Recruiting | MT-601 | NCT05798897 |
| Phase 1 | Not yet recruiting | MT-601 dose 200 million cells, MT-601 dose 400 million cells | NCT06549751 |
| Phase 1 | Recruiting | MT-401-OTS | NCT06552416 |
| Not applicable | Completed | Marker Therapeutics D2000 Cartridge (D2000) for use with the Spectra Optia® Apheresis System (Optia SPD Protocol) | NCT04358003 |