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Marker Therapeutics, Inc. (MRKR)

Marker Therapeutics, Inc. is a clinical-stage immuno-oncology company focused on discovering and bringing to market a variety of T cell-based immunotherapies and peptide-based vaccines. These cutting-edge treatments are engineered to address both blood cancers (hematological malignancies) and solid tumor conditions across the United States. A cornerstone of their approach is the proprietary MultiTAA-specific T cell technology. This method involves producing T cells that are not genetically modified but are specifically designed to target tumors. These specialized T cells can identify multiple antigens associated with tumors, allowing them to effectively eliminate cancer cells that express these markers. Marker Therapeutics' MultiTAA-specific T cell therapies encompass patient-derived (autologous) T cells for treating lymphoma and various solid tumors, as well as donor-derived (allogeneic) T cells for acute myeloid leukemia and acute lymphoblastic leukemia. They also provide "off-the-shelf" solutions applicable to a range of diseases. In addition to T cell therapies, the company is advancing peptide-based immunotherapeutic vaccines. This pipeline includes TPIV100/110, developed to combat breast and ovarian cancer cells, and TPIV200, which is currently undergoing Phase 2 clinical trials for the treatment of breast and ovarian cancers. Founded in 1999, Marker Therapeutics maintains its headquarters in Houston, Texas.

Sector: Pharmaceutical Preparations

Industry: Biotechnology

Marker Therapeutics, Inc. logo

Marker Therapeutics, Inc.

NASDAQ:MRKRHealthcare
-2.97%$0.9800
AH$0.9800+0.00%vs close
Mkt Cap$16.34M
Float16.08M
O/S16.67M
Vol
$ Vol
RVOL
Inst Own23.8%
SI0.7%
Earnings
Dilution
Phase Distribution
7 lead-sponsored trials·2 active·2 completed
Phase 13
Phase 23
Not applicable1
(2 more as collaborator)
Status Overview
Not yet recruiting1
Recruiting2
Completed2
Stopped2

Trials need funding. See this company's dilution risk and cash position.

Clinical Trials
Sponsor role
Status
Phase
  • Phase 2
    Completed

    Folate Receptor Alpha Peptide Vaccine With GM-CSF in Patients With Triple Negative Breast Cancer

    Low dose FRα vaccine, Cyclophosphamide

    Breast Cancer

    Enrollment
    80
    Start
    Apr 2016
    Primary Completion
    Jul 2021
    Completion
    Jul 2021
    NCT02593227
  • Phase 2
    Terminated

    Folate Receptor Alpha Peptide Vaccine With GM-CSF Versus GM-CSF Alone in Patients With Platinum Sensitive Ovarian Cancer

    FRα peptide plus Adjuvant (GM-CSF), Adjuvant (GM-CSF) Alone

    Platinum Sensitive Ovarian Cancer, Ovarian Cancer

    Enrollment
    120
    Start
    Jul 2017
    Primary Completion
    Jan 2020
    Completion
    Jan 2020
    NCT02978222
  • Phase 2
    Terminated

    Efficacy of MT-401 in Patients With AML Following Stem Cell Transplant

    MT-401

    Acute Myeloid Leukemia, Stem Cell Transplantation

    Enrollment
    92
    Start
    Oct 2020
    Primary Completion
    Mar 2024
    Completion
    Mar 2024
    NCT04511130
  • Phase 1
    Recruiting

    Safety and Preliminary Efficacy of MT-601 in Patients With Relapsed/Refractory Lymphoma

    MT-601

    Non-Hodgkin Lymphoma, Adult, Non-Hodgkin Lymphoma, Refractory +5

    Enrollment
    79
    Start
    Jan 2023
    Primary Completion
    Feb 2028est.
    Completion
    Feb 2028est.
    NCT05798897
  • Phase 1
    Not yet recruiting

    MT-601 Administered To Patients With Locally Advanced Unresectable or Metastatic Pancreatic Cancer

    MT-601 dose 200 million cells, MT-601 dose 400 million cells

    Pancreas Cancer, Pancreatic Cancer Metastatic +1

    Enrollment
    38
    Start
    Jul 2026est.
    Primary Completion
    Jul 2028est.
    Completion
    Sep 2028est.
    NCT06549751
  • Phase 1
    Recruiting

    Safety of MT-401-OTS in Patients With Relapsed AML or MDS

    MT-401-OTS

    Acute Myeloid Leukemia, in Relapse, MDS

    Enrollment
    40
    Start
    Jun 2025
    Primary Completion
    Sep 2029est.
    Completion
    Sep 2029est.
    NCT06552416
  • Not applicable
    Completed

    Plasma Adsorption in Patients With Confirmed COVID-19

    Marker Therapeutics D2000 Cartridge (D2000) for use with the Spectra Optia® Apheresis System (Optia SPD Protocol)

    Respiratory Failure, ARDS

    Enrollment
    107
    Start
    May 2020
    Primary Completion
    Nov 2021
    Completion
    Apr 2022
    NCT04358003