Nkarta, Inc. (NKTX)
Nkarta, Inc., a clinical-stage biopharmaceutical company, develops and commercializes natural killer cell therapies for cancer and autoimmune disease treatment. Its lead product candidate is NKX019, a chimeric antigen receptor-natural killer (CAR NK) targeting the CD19 antigen, which is in Phase 1 clinical trial for the treatment of lupus nephritis; systemic sclerosis; idiopathic inflammatory myopathy; and antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, as well as for systemic lupus erythematosus and myasthenia gravis. The company has a research collaboration agreement with CRISPR Therapeutics AG. Nkarta, Inc. was incorporated in 2015 and is based in South San Francisco, California.
Sector: Pharmaceutical Preparations
Industry: Biotechnology
Nkarta, Inc.
Trials need funding. See this company's dilution risk and cash position.
- Phase 1/2Recruiting
A Phase 1/2 Study of NKX019 in Subjects With Autoimmune Disease (Ntrust-1)
NKX019, Fludarabine, Cyclophosphamide
Lupus Nephritis, Primary Membranous Nephropathy
NCT06557265Enrollment120StartJun 2024Primary CompletionApr 2027est.CompletionApr 2027est. - Phase 1/2Recruiting
A Phase 1/2 Study of NKX019 in Subjects With Immune-Mediated Diseases (Ntrust-2)
NKX019, Fludarabine
Systemic Sclerosis, Idiopathic Inflammatory Myopathies +2
NCT06733935Enrollment240StartNov 2024Primary CompletionOct 2028est.CompletionOct 2028est. - Phase 1Active, not recruiting
NKX101, Intravenous Allogeneic CAR NK Cells, in Adults With AML or MDS
NKX101 - CAR NK cell therapy
Relapsed/Refractory AML, AML, Adult +2
NCT04623944Enrollment61StartSep 2020Primary CompletionOct 2024CompletionJul 2039est. - Phase 1Active, not recruiting
NKX019, Intravenous Allogeneic Chimeric Antigen Receptor Natural Killer Cells (CAR NK), in Adults With B-cell Cancers
NKX019
Lymphoma, Non-Hodgkin, B-cell Acute Lymphoblastic Leukemia +8
NCT05020678Enrollment150StartAug 2021Primary CompletionMar 2025CompletionDec 2038est.
| Drug / Therapy | Link | ||
|---|---|---|---|
| Phase 1/2 | Recruiting | NKX019, Fludarabine, Cyclophosphamide | NCT06557265 |
| Phase 1/2 | Recruiting | NKX019, Fludarabine | NCT06733935 |
| Phase 1 | Active, not recruiting | NKX101 - CAR NK cell therapy | NCT04623944 |
| Phase 1 | Active, not recruiting | NKX019 | NCT05020678 |