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PRECIGEN, INC. (PGEN)

Precigen, Inc. is an American company dedicated to the discovery and development of cutting-edge gene and cellular therapies. The company also offers disease-modifying treatments, genetically engineered swine for regenerative medicine, and advanced reproductive and embryo transfer technologies. Its extensive portfolio of proprietary platforms includes UltraVector, which leverages advanced DNA construction and computational modeling to engineer complex gene expression programs; mbIL15, a gene designed to enhance immune cell function; the non-viral Sleeping Beauty transposon/transposase system for genetic modification; and AttSite recombinases, tools for precise DNA recombination. Furthermore, Precigen utilizes its AdenoVerse platform, a library of engineered adenovectors for gene delivery and immunotherapy applications, alongside L. lactis, a food-grade bacterium. The company also provides RheoSwitch, an inducible gene switch system offering quantitative, dose-proportionate control over target protein expression's timing and amount; kill switches, designed to selectively eliminate cell therapies within the body; tissue-specific promoters for targeted gene expression; the UltraCAR-T platform for cancer treatment; and the ActoBiotics platform, which employs genetically modified bacteria to deliver proteins and peptides directly to mucosal sites. Precigen maintains strategic collaboration and license agreements with Alaunos Therapeutics, Inc., Ares Trading S.A., Oragenics, Inc., Castle Creek Biosciences, Inc., and Intrexon Energy Partners I and II, LLC. Established in 1998, Precigen, Inc., previously known as Intrexon Corporation, adopted its current name in January 2020 and is headquartered in Germantown, Maryland.

Sector: Pharmaceutical Preparations

Industry: Biotechnology

Precigen, Inc. logo

Precigen, Inc.

NASDAQ:PGENHealthcare
+4.52%$6.94
AH$5.30-23.63%vs close
Mkt Cap$2.48B
Float177.86M
O/S358.04M
Vol
$ Vol
RVOL
Inst Own39.0%
SI26.1%
Earnings
Dilution
Phase Distribution
6 lead-sponsored trials·5 active·0 completed
Phase 12
Phase 1/21
Phase 21
Phase 31
Phase 41
(4 more as collaborator)
Status Overview
Not yet recruiting1
Recruiting2
Active, not recruiting3

Trials need funding. See this company's dilution risk and cash position.

Clinical Trials
Sponsor role
Status
Phase
  • Phase 4
    Recruiting

    Zopa Retreatment and Vector Shedding in Adults With RRP

    Zopapogene imadenovec (Zopa)

    Recurrent Respiratory Papillomatosis, Papillomavirus Infection +1

    Enrollment
    30
    Start
    Jul 2024
    Primary Completion
    Dec 2027est.
    Completion
    Dec 2028est.
    NCT06538480
  • Phase 3
    Not yet recruiting

    Zopapogene Imadenovec for the Treatment of Recurrent Respiratory Papillomatosis in Children

    Zopapogene imadenovec-drba

    Recurrent Respiratory Papillomatosis (RRP), Juvenile-onset Recurrent Respiratory Papillomatosis +1

    Enrollment
    15
    Start
    Dec 2026est.
    Primary Completion
    Jan 2029est.
    Completion
    Jan 2033est.
    NCT07901738
  • Phase 2
    Recruiting

    PRGN-2009 in Combination With Pembrolizumab in Patients With Recurrent or Metastatic Cervical Cancer

    PRGN-2009 plus Pembrolizumab

    Cervical Cancer, HPV-Related Carcinoma +3

    Enrollment
    24
    Start
    Nov 2025
    Primary Completion
    Nov 2026est.
    Completion
    Nov 2030est.
    NCT06157151
  • Phase 1/2
    Active, not recruiting

    Adjuvant PRGN-2012 in Adult Patients With Recurrent Respiratory Papillomatosis

    PRGN-2012 - Phase I; Dose Level 1, PRGN-2012 - Phase I; Dose Level 2

    Recurrent Respiratory Papillomatosis, Papillomavirus Infections +1

    Enrollment
    38
    Start
    Mar 2021
    Primary Completion
    Jun 2024
    Completion
    Jun 2026est.
    NCT04724980
  • Phase 1
    Active, not recruiting

    Modified Immune Cells (Autologous CAR T Cells) in Treating Patients with Advanced, Recurrent Platinum Resistant Ovarian, Fallopian Tube or Primary Peritoneal Cancer

    PRGN-3005 UltraCAR-T cells, PRGN-3005 UltraCAR-T cells

    Platinum-Resistant Fallopian Tube Carcinoma, Platinum-Resistant Ovarian Carcinoma +32

    Enrollment
    71
    Start
    Apr 2019
    Primary Completion
    Dec 2024est.
    Completion
    Nov 2028est.
    NCT03907527
  • Phase 1
    Active, not recruiting

    PRGN-3006 Adoptive Cellular Therapy for CD33-Positive Relapsed or Refractory AML, MRD Positive AML or Higher Risk MDS

    PRGN-3006 T Cells

    Acute Myeloid Leukemia, Myelodysplastic Syndromes

    Enrollment
    88
    Start
    May 2019
    Primary Completion
    Aug 2024
    Completion
    Aug 2025est.
    NCT03927261