PRECIGEN, INC. (PGEN)
Precigen, Inc. is an American company dedicated to the discovery and development of cutting-edge gene and cellular therapies. The company also offers disease-modifying treatments, genetically engineered swine for regenerative medicine, and advanced reproductive and embryo transfer technologies. Its extensive portfolio of proprietary platforms includes UltraVector, which leverages advanced DNA construction and computational modeling to engineer complex gene expression programs; mbIL15, a gene designed to enhance immune cell function; the non-viral Sleeping Beauty transposon/transposase system for genetic modification; and AttSite recombinases, tools for precise DNA recombination. Furthermore, Precigen utilizes its AdenoVerse platform, a library of engineered adenovectors for gene delivery and immunotherapy applications, alongside L. lactis, a food-grade bacterium. The company also provides RheoSwitch, an inducible gene switch system offering quantitative, dose-proportionate control over target protein expression's timing and amount; kill switches, designed to selectively eliminate cell therapies within the body; tissue-specific promoters for targeted gene expression; the UltraCAR-T platform for cancer treatment; and the ActoBiotics platform, which employs genetically modified bacteria to deliver proteins and peptides directly to mucosal sites. Precigen maintains strategic collaboration and license agreements with Alaunos Therapeutics, Inc., Ares Trading S.A., Oragenics, Inc., Castle Creek Biosciences, Inc., and Intrexon Energy Partners I and II, LLC. Established in 1998, Precigen, Inc., previously known as Intrexon Corporation, adopted its current name in January 2020 and is headquartered in Germantown, Maryland.
Sector: Pharmaceutical Preparations
Industry: Biotechnology
Precigen, Inc.
Trials need funding. See this company's dilution risk and cash position.
- Phase 4Recruiting
Zopa Retreatment and Vector Shedding in Adults With RRP
Zopapogene imadenovec (Zopa)
Recurrent Respiratory Papillomatosis, Papillomavirus Infection +1
NCT06538480Enrollment30StartJul 2024Primary CompletionDec 2027est.CompletionDec 2028est. - Phase 3Not yet recruiting
Zopapogene Imadenovec for the Treatment of Recurrent Respiratory Papillomatosis in Children
Zopapogene imadenovec-drba
Recurrent Respiratory Papillomatosis (RRP), Juvenile-onset Recurrent Respiratory Papillomatosis +1
NCT07901738Enrollment15StartDec 2026est.Primary CompletionJan 2029est.CompletionJan 2033est. - Phase 2Recruiting
PRGN-2009 in Combination With Pembrolizumab in Patients With Recurrent or Metastatic Cervical Cancer
PRGN-2009 plus Pembrolizumab
Cervical Cancer, HPV-Related Carcinoma +3
NCT06157151Enrollment24StartNov 2025Primary CompletionNov 2026est.CompletionNov 2030est. - Phase 1/2Active, not recruiting
Adjuvant PRGN-2012 in Adult Patients With Recurrent Respiratory Papillomatosis
PRGN-2012 - Phase I; Dose Level 1, PRGN-2012 - Phase I; Dose Level 2
Recurrent Respiratory Papillomatosis, Papillomavirus Infections +1
NCT04724980Enrollment38StartMar 2021Primary CompletionJun 2024CompletionJun 2026est. - Phase 1Active, not recruiting
Modified Immune Cells (Autologous CAR T Cells) in Treating Patients with Advanced, Recurrent Platinum Resistant Ovarian, Fallopian Tube or Primary Peritoneal Cancer
PRGN-3005 UltraCAR-T cells, PRGN-3005 UltraCAR-T cells
Platinum-Resistant Fallopian Tube Carcinoma, Platinum-Resistant Ovarian Carcinoma +32
NCT03907527Enrollment71StartApr 2019Primary CompletionDec 2024est.CompletionNov 2028est. - Phase 1Active, not recruiting
PRGN-3006 Adoptive Cellular Therapy for CD33-Positive Relapsed or Refractory AML, MRD Positive AML or Higher Risk MDS
PRGN-3006 T Cells
Acute Myeloid Leukemia, Myelodysplastic Syndromes
NCT03927261Enrollment88StartMay 2019Primary CompletionAug 2024CompletionAug 2025est.
| Drug / Therapy | Link | ||
|---|---|---|---|
| Phase 4 | Recruiting | Zopapogene imadenovec (Zopa) | NCT06538480 |
| Phase 3 | Not yet recruiting | Zopapogene imadenovec-drba | NCT07901738 |
| Phase 2 | Recruiting | PRGN-2009 plus Pembrolizumab | NCT06157151 |
| Phase 1/2 | Active, not recruiting | PRGN-2012 - Phase I; Dose Level 1, PRGN-2012 - Phase I; Dose Level 2 | NCT04724980 |
| Phase 1 | Active, not recruiting | PRGN-3005 UltraCAR-T cells, PRGN-3005 UltraCAR-T cells | NCT03907527 |
| Phase 1 | Active, not recruiting | PRGN-3006 T Cells | NCT03927261 |