ProQR Therapeutics N.V. (PRQR)
ProQR Therapeutics N.V. operates as a biopharmaceutical enterprise dedicated to discovering and developing RNA-based therapies designed to address genetic disorders. The company's pipeline includes two primary drug candidates in advanced clinical stages: Sepofarsen is currently in a Phase II/III clinical trial, known as the ILLUMINATE trial, targeting Leber Congenital Amaurosis 10 (LCA10). Ultevursen is also undergoing Phase II/III evaluation for the treatment of USH2A-mediated retinitis pigmentosa and Usher syndrome. Beyond its clinical programs, ProQR is actively developing its proprietary Axiomer RNA base-editing platform technology. Strategic collaborations are central to ProQR's strategy, evidenced by its licensing agreements with institutions such as Radboud University Medical Center, Inserm Transfert SA, Ionis Pharmaceuticals, Inc., and Leiden University Medical Center. Furthermore, a significant license and research partnership exists with Eli Lilly and Company, focused on the discovery, advancement, and commercialization of novel medicines for genetic conditions impacting the liver and nervous system. Established in 2012, ProQR Therapeutics N.V. maintains its corporate headquarters in Leiden, the Netherlands.
Sector: Pharmaceutical Preparations
Industry: Biotechnology
ProQR Therapeutics N.V.
NASDAQ:PRQRHealthcare · Biotechnology
-3.47%$1.39
AH$1.43+2.88%vs close
Mkt Cap$196.16M
Float118.18M
O/S141.12M
Vol
$ Vol
RVOL
Inst Own43.0%
SI2.5%
Earnings
Dilution
Financials Summary
Revenue$17.07M
Net Income-$45.27M
Total Assets$147.95M
Free Cash Flow-$60.12M
Debt & Equity
Debt 22%
Equity 78%
Total Debt$18.36M
Total Equity$64.78M
Shares Outstanding
Short Interest
Split History
No splits on record
Nothing in PRQR's public trading history: no forward or reverse split has affected the share count.
Balance Sheet Details
Assets$147.95M
Liabilities$83.16M
Accounts Receivable$6.67M
Accounts Payable$391K
Inventory$0
PP&E (Net)$16.57M
Goodwill$0
Intangible Assets$0
Income Statement
| Period | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 | FY 2015 | FY 2014 | FY 2013 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Currency | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD |
| Period Ending | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | 2020-12-31 | 2019-12-31 | 2018-12-31 | 2017-12-31 | 2016-12-31 | 2015-12-31 | 2014-12-31 | 2013-12-31 |
| Revenue | $17.07M | $21.12M | $7.28M | $4.02M | $1.49M | $1.15M | $2.16M | $5.52M | -$1.71M | $2.55M | $10.51M | $350K | $0 |
| YoY Growth | -19.2% | 190.2% | 81.2% | 169.2% | 29.7% | -46.8% | -60.9% | -423.2% | -167.0% | -75.7% | 2905.4% | - | - |
| Cost of Revenue | $2.9M | $0 | $0 | $0 | $0 | $0 | $130.51M | $1.1M | $1.12M | $1.43M | $539K | $0 | $0 |
| Gross Profit | $14.17M | $21.12M | $7.28M | $4.02M | $1.49M | $1.15M | -$128.36M | $4.42M | -$2.83M | $1.12M | $9.97M | $350K | $0 |
| Gross Margin | 83.0% | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% | -5943.6% | 80.1% | 165.5% | 43.8% | 94.9% | 100.0% | - |
| Research and Development | $45.49M | $40.62M | $28.1M | $56.83M | $47.17M | $42.6M | $51.94M | $32.97M | $34.8M | $35.66M | $26.14M | $11.47M | $2.87M |
| Selling, General, and Administrative | $16.83M | $15.26M | $18.14M | $20.84M | $19.4M | $15.29M | $14.4M | $14.01M | $12.11M | $10.59M | $7.64M | $7.27M | $878K |
| Other | -$1.05M | -$715K | -$3.36M | -$855K | -$1.17M | -$9.41M | $2.16M | $6.44M | $1.67M | $2.04M | $3.61M | $0 | $0 |
| Total Operating Expenses | $61.26M | $55.16M | $42.87M | $76.81M | $65.41M | $48.48M | $66.34M | $46.98M | $46.91M | $46.25M | $33.78M | $18.74M | $3.62M |
| Operating Income (EBIT) | -$47.1M | -$34.04M | -$35.59M | -$72.8M | -$63.92M | -$47.33M | -$64.18M | -$40.55M | -$45.24M | -$44.21M | -$30.17M | -$18.39M | -$3.62M |
| Operating Margin | -275.9% | -161.2% | -489.1% | -1813.0% | -4285.4% | -4117.4% | -2971.8% | -734.5% | 2648.7% | -1734.1% | -287.1% | -5259.1% | - |
| Interest Expense | $968K | $1.2M | $1.34M | $5.73M | $3.8M | $2.28M | $1.21M | $905K | $666K | $601K | $441K | $296K | $42K |
| Interest Income | $2.5M | $3.63M | $2.9M | $118K | $6K | $350K | $449K | -$885K | -$3.55M | $525K | $6.89M | $4.84M | $27K |
| Other Income (Expense) | $1.85M | $2.81M | $4.52M | $1.17M | -$3.88M | -$4.61M | $131.44M | -$885K | $950K | $525K | $6.89M | $4.84M | -$16K |
| Income Before Tax (EBT) | -$45.25M | -$31.24M | -$31.07M | -$71.62M | -$67.79M | -$51.94M | -$63.25M | -$41.43M | -$48.79M | -$43.69M | -$23.27M | -$13.55M | -$3.63M |
| Income Tax Expense | $20K | -$220K | -$87K | $107K | $131K | $139K | $147K | $1K | $2K | $0 | $0 | $0 | $27K |
| Net Income | -$45.27M | -$31.02M | -$31.41M | -$71.97M | -$67.86M | -$52.02M | -$63.4M | -$41.22M | -$48.75M | -$43.69M | -$23.27M | -$13.55M | -$3.63M |
| Net Income Margin | -265.2% | -146.9% | -431.7% | -1792.5% | -4549.8% | -4525.3% | -2935.6% | -746.7% | 2854.0% | -1713.5% | -221.5% | -3874.4% | - |
| Supplementary Data | |||||||||||||
| EPS | -0.38 | -0.34 | -0.35 | -0.91 | -0.96 | -0.93 | -1.38 | -1.08 | -1.72 | -1.67 | -0.89 | -0.55 | -0.15 |
| Diluted EPS | -0.38 | -0.34 | -0.35 | -0.91 | -0.96 | -0.93 | -1.38 | -1.08 | -1.72 | -1.67 | -0.89 | -0.55 | -0.15 |
| Weighted Average OS | 105.33M | 81.67M | 81.01M | 71.64M | 64.18M | 50.06M | 41.04M | 34.05M | 25.37M | 23.35M | 23.34M | 22.15M | 22.21M |
| EBITDA | -$41.26M | -$26.95M | -$26.92M | -$63.08M | -$61.39M | -$54.11M | -$190.26M | -$39.42M | $1.19M | -$40.18M | -$94.12M | -$55.52M | -$3.56M |
| EBITDA Margin | -241.7% | -127.6% | -369.9% | -1571.0% | -4116.0% | -4707.1% | -8810.2% | -714.1% | -69.7% | -1575.9% | -895.5% | -15877.3% | - |
Balance Sheet
| Period | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 | FY 2015 | FY 2014 | FY 2013 | FY 2012 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Currency | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD |
| Period Ending | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | 2020-12-31 | 2019-12-31 | 2018-12-31 | 2017-12-31 | 2016-12-31 | 2015-12-31 | 2014-12-31 | 2013-12-31 | 2012-12-31 |
| Assets | ||||||||||||||
| Current Assets | ||||||||||||||
| Cash and Cash Equivalents | $121.25M | $172.84M | $146.77M | $113M | $238.25M | $103.67M | $140.39M | $134.84M | $64.53M | $69.76M | $115.13M | $152.4M | $6.36M | $367K |
| Short-Term Investments | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Cash and Short-Term Investments | $121.25M | $172.84M | $146.77M | $113M | $238.25M | $103.67M | $140.39M | $134.84M | $64.53M | $69.76M | $115.13M | $152.4M | $6.36M | $367K |
| Accounts Receivable | $6.67M | $2.34M | $1.56M | $68.24M | $1.05M | $1.09M | $1.49M | $2.74M | $629K | $1.84M | $1.82M | $1.02M | $199K | $69K |
| Inventory | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Other Current Assets | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Total Current Assets | $131.37M | $177.98M | $149.31M | $184.17M | $243.28M | $109.38M | $143.8M | $138.4M | $67.83M | $73.08M | $118.65M | $153.97M | $6.56M | $440K |
| Long-Term Assets | ||||||||||||||
| Property, Plant & Equipment Net | $16.57M | $16.33M | $20.85M | $19.36M | $22.19M | $25.43M | $3.06M | $2.38M | $3.36M | $4.05M | $2.67M | $1.6M | $314K | $0 |
| Goodwill | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Intangible Assets | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $52K | $106K | $171K | $220K | $60K | $57K |
| Long-Term Investments | $0 | $0 | $0 | $740K | $799K | $146K | $538K | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Deferred Tax Assets | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Other Long-Term Assets | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Total Long-Term Assets | $16.57M | $16.33M | $20.85M | $20.1M | $22.99M | $25.57M | $3.6M | $2.38M | $3.41M | $4.16M | $2.84M | $1.83M | $374K | $57K |
| Other Assets | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Total Assets | $147.95M | $194.3M | $170.16M | $204.27M | $266.27M | $134.96M | $147.4M | $140.78M | $71.24M | $77.23M | $121.49M | $155.8M | $6.93M | $498K |
| Liabilities | ||||||||||||||
| Current Liabilities | ||||||||||||||
| Accounts Payable | $391K | $19K | $1.9M | $467K | $243K | $302K | $558K | $172K | $732K | $387K | $1.07M | $1.69M | $1.15M | $140K |
| Short-Term Debt | $5.83M | $5.17M | $1.99M | $4.63M | $8.01M | $3.27M | $1.07M | $0 | $2.63M | $0 | $18K | $46K | $3.9M | $0 |
| Current Income Tax Payable | $0 | $0 | $0 | $0 | $0 | $0 | $72K | $0 | $1.14M | $349K | $263K | $381K | $32K | $3K |
| Current Unearned Revenue | $23.03M | $25.38M | $25.38M | $6.73M | $6.5M | $957K | $892K | $696K | $466K | $0 | $175K | $0 | $0 | $0 |
| Other Current Liabilities | $13.31M | $14.44M | $12.93M | $13.2M | $20.31M | $9.54M | $11.19M | $9.54M | $7.57M | $7.51M | $5.37M | $2.17M | $496K | $71K |
| Total Current Liabilities | $42.57M | $45M | $42.21M | $25.02M | $35.06M | $14.08M | $13.79M | $10.42M | $11.39M | $7.91M | $6.66M | $4.07M | $5.55M | $211K |
| Long-Term Liabilities | ||||||||||||||
| Long-Term Debt | $0 | $0 | $5.3M | $5.09M | $49.95M | $22.13M | $15.94M | $8.98M | $7.09M | $5.42M | $5.85M | $3.8M | $1.42M | $140K |
| Long-Term Unearned Revenue | $28.07M | $34.05M | $54.51M | $78.18M | $18.66M | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $32K | $1K |
| Long-Term Deferred Tax Liabilities | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Other Long-Term Liabilities | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $3M | $0 | $1.3M | $0 | $0 | $0 | $0 |
| Total Long-Term Liabilities | $40.6M | $46.85M | $76.87M | $99.74M | $87.35M | $43.58M | $15.94M | $11.99M | $7.09M | $6.71M | $5.85M | $3.82M | $1.53M | $141K |
| Other Liabilities | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Total Liabilities | $83.16M | $91.85M | $119.08M | $124.77M | $122.41M | $57.66M | $29.72M | $22.41M | $18.48M | $14.62M | $12.51M | $7.9M | $7.07M | $352K |
| Stockholders' Equity | ||||||||||||||
| Preferred Stock | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Common Stock | $5.65M | $4.98M | $4.16M | $4.02M | $3.81M | $2.96M | $2.71M | $2.2M | $1.95M | $1.1M | $1.13M | $1.26M | $91K | $49K |
| Retained Earnings | -$613.41M | -$494.16M | -$494.69M | -$452.02M | -$403.72M | -$352.33M | -$265.54M | -$198.52M | -$160.14M | -$89.24M | -$44.45M | -$21.36M | -$5.65M | -$616K |
| Comprehensive Income & Other | $37.65M | $31.93M | $32.06M | $36.08M | $38.49M | $32.69M | $20.95M | $13.91M | $11.42M | $5.11M | $2.31M | $929K | $63K | $0 |
| Other Stockholders' Equity | $672.54M | $591.63M | $541.62M | $527.97M | $544.54M | $427.41M | $381.13M | $314.98M | $210.99M | $150.75M | $152.3M | $167.99M | $5.42M | $713K |
| Total Equity | $64.78M | $102.45M | $51.08M | $79.96M | $144.62M | $78.04M | $118.29M | $118.66M | $52.81M | $62.61M | $108.98M | $147.9M | -$137K | $146K |
| Minority Interest | $0 | $0 | $0 | -$458K | -$767K | -$745K | -$622K | -$294K | -$51K | $0 | $0 | $0 | $0 | $0 |
| Total Liabilities and Equity | $147.95M | $194.3M | $170.16M | $204.73M | $267.03M | $135.7M | $148.02M | $141.07M | $71.29M | $77.23M | $121.49M | $155.8M | $6.93M | $498K |
| Supplementary Data | ||||||||||||||
| Total Debt | $18.36M | $17.97M | $24.35M | $26.2M | $76.7M | $46.85M | $17.01M | $8.98M | $9.72M | $5.42M | $5.87M | $3.87M | $5.4M | $140K |
| Net Debt | -$102.9M | -$154.87M | -$122.41M | -$86.81M | -$161.54M | -$56.81M | -$123.39M | -$125.85M | -$54.81M | -$64.34M | -$109.26M | -$148.53M | -$961K | -$227K |
Cash Flow Statement
| Period | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 | FY 2015 | FY 2014 | FY 2013 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Currency | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD |
| Period Ending | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | 2020-12-31 | 2019-12-31 | 2018-12-31 | 2017-12-31 | 2016-12-31 | 2015-12-31 | 2014-12-31 | 2013-12-31 |
| Operating Activities | |||||||||||||
| Net Income | -$47.13M | -$31.02M | -$30.99M | -$71.73M | -$67.92M | -$52.08M | -$63.4M | -$41.43M | -$48.63M | -$43.7M | -$23.27M | -$13.55M | -$3.63M |
| Depreciation & Amortization | $3.02M | $3.08M | $2.81M | $2.82M | $2.6M | $2.63M | $2.29M | $1.11M | $1.19M | $1.39M | $536K | $141K | $27K |
| Deferred Income Tax | $21K | -$220K | -$87K | $107K | $131K | $139K | $147K | $114K | $162K | $264K | $493K | $159K | $15K |
| Stock-Based Compensation | $4.48M | $2.84M | $3.47M | $3.21M | $6.94M | $8.76M | $10.18M | $3.6M | $4.5M | $2.74M | $1.35M | $722K | $46K |
| Changes in Working Capital: | |||||||||||||
| Accounts Receivable | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | -$90K |
| Inventory | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Accounts Payable | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Other Working Capital | -$19.46M | -$14.82M | $54.69M | -$5.58M | $27.95M | -$6.12M | $1.89M | $1.45M | $183K | $1.6M | $712K | $1.22M | $1.02M |
| Total Working Capital Change | -$19.46M | -$14.82M | $54.69M | -$5.58M | $27.95M | -$6.12M | $1.89M | $1.45M | $183K | $1.6M | $712K | $1.22M | $926K |
| Other Non-Cash Items | $83K | -$530K | -$5.83M | -$5.36M | $1.24M | -$5.91M | -$235K | $885K | $3.55M | -$525K | -$6.89M | -$4.84M | $16K |
| Net Cash from Operating | -$58.98M | -$40.66M | $24.07M | -$76.54M | -$29.06M | -$52.58M | -$49.12M | -$34.28M | -$39.05M | -$38.23M | -$27.07M | -$16.15M | -$2.61M |
| Investing Activities | |||||||||||||
| Capital Expenditures | -$1.14M | -$1.58M | -$1.53M | -$791K | -$541K | -$1.03M | -$648K | -$349K | -$135K | -$2.84M | -$1.48M | -$1.38M | -$153K |
| Acquisitions | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Purchases of Investments | $0 | -$18.99M | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Sales of Investments | $0 | $18.99M | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Other Investing Activities | $0 | -$2.97M | $6.31M | $7K | $66K | $0 | $0 | $0 | $0 | $0 | -$31K | $0 | $0 |
| Net Cash from Investing | -$1.14M | -$4.55M | $4.78M | -$784K | -$475K | -$1.03M | -$648K | -$349K | -$135K | -$2.84M | -$1.48M | -$1.38M | -$153K |
| Financing Activities | |||||||||||||
| Debt Repaid | $2.13M | $1.77M | $2.94M | $50.33M | -$29.98M | -$15.38M | -$1.63M | -$1.56M | -$1.06M | -$397K | -$1.79M | -$1.82M | -$3.72M |
| Common Stock Issuance | $77K | $80.03M | $0 | $15.78M | $121.19M | $0 | $54.24M | $94.06M | $28.7M | $2K | $16K | $132.11M | $3.38M |
| Common Stock Repurchases | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Dividends Paid | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Other Financing Activities | $0 | $249K | $395K | $38K | $1.7M | $821K | $216K | $972K | $4K | $2K | $16K | $0 | $0 |
| Net Cash from Financing | -$2.05M | $78.51M | -$2.54M | -$34.51M | $152.87M | $16.2M | $56.08M | $99.04M | $29.76M | $399K | $1.81M | $133.93M | $7.09M |
| Forex Effect | -$1.51M | $752K | $669K | $8.21M | $1.44M | -$2.94M | $806K | -$191K | -$2.98M | $824K | $6.78M | $4.93M | $0 |
| Net Change in Cash | -$63.67M | $34.06M | $26.98M | -$103.62M | $124.78M | -$40.34M | $7.12M | $64.22M | -$12.4M | -$39.84M | -$19.97M | $121.34M | $4.33M |
| Supplementary Data | |||||||||||||
| Operating Cash Flow | -$58.98M | -$40.66M | $24.07M | -$76.54M | -$29.06M | -$52.58M | -$49.12M | -$34.28M | -$39.05M | -$38.23M | -$27.07M | -$16.15M | -$2.61M |
| Capital Expenditure | -$1.14M | -$1.58M | -$1.53M | -$791K | -$541K | -$1.03M | -$648K | -$349K | -$135K | -$2.84M | -$1.48M | -$1.38M | -$153K |
| Free Cash Flow | -$60.12M | -$42.24M | $22.54M | -$77.33M | -$29.6M | -$53.61M | -$49.77M | -$34.63M | -$39.18M | -$41.07M | -$28.55M | -$17.53M | -$2.76M |
| Cash at Beginning | $166.92M | $132.86M | $105.88M | $209.5M | $84.73M | $125.07M | $117.95M | $53.74M | $66.14M | $105.98M | $125.95M | $4.61M | $278K |
| Cash at End | $103.24M | $166.92M | $132.86M | $105.88M | $209.5M | $84.73M | $125.07M | $117.95M | $53.74M | $66.14M | $105.98M | $125.95M | $4.61M |