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PROTHENA CORP PUBLIC LTD CO (PRTA)

Prothena Corporation plc, a late-stage clinical biotechnology company, focuses on discovery and development of novel therapies to treat diseases caused by protein dysregulation. Its product pipeline includes Prasinezumab, an investigational humanized monoclonal antibody which is in Phase 3 clinical trial for the treatment of parkinson's disease and other synucleinopathies. The company also develops Coramitug, an investigational antibody, which is in Phase 3 clinical trial for the treatment of transthyretin amyloidosis; BMS-986446, an anti-tau antibody which is in Phase 2 clinical trial to treat Alzheimer's disease; PRX019, an investigational antibody which is in Phase 1 clinical trial for the treatment of neurodegenerative diseases; and PRX123, a Dual Aß-Tau Vaccine, which is in preclinical trial for treating Alzheimer's disease. In addition, it develops discovery- and late-preclinical-stage programs include TDP-43 CYTOPE for the treatment of amyotrophic lateral sclerosis; PRX012, a next-generation anti-Aß antibody which is in phase 1 clinical trial to treat Alzheimer's disease; and PRX012-TfR, a preclinical program for the treatment of Alzheimer's disease. It has a license, development, and commercialization agreement with F. Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc. to develop and commercialize antibodies that target a-synuclein, including prasinezumab; and master collaboration agreement with Bristol Myers Squibb to develop and commercialize antibodies targeting tau, TDP-43. Prothena Corporation plc was incorporated in 2012 and is based in Dublin, Ireland.

Sector: Pharmaceutical Preparations

Industry: Biotechnology

Prothena Corporation plc logo

Prothena Corporation plc

NASDAQ:PRTAHealthcare
-4.62%$8.47
AH$8.47+0.00%vs close
Mkt Cap$434.82M
Float41.96M
O/S51.34M
Vol
$ Vol
RVOL
Inst Own92.0%
SI18.9%
Earnings
Dilution
Financials Summary
Revenue$9.68M
Net Income-$244.09M
Total Assets$326.8M
Free Cash Flow-$163.72M
Debt & Equity
Debt 5%
Equity 95%
Total Debt$13.86M
Total Equity$280.47M
Shares Outstanding
Short Interest
Split History

No splits on record

Nothing in PRTA's public trading history: no forward or reverse split has affected the share count.

Balance Sheet Details
Assets$326.8M
Liabilities$46.33M
Accounts Receivable$0
Accounts Payable$5.88M
Inventory$0
PP&E (Net)$10.27M
Goodwill$0
Intangible Assets$0
Income Statement
PeriodFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016FY 2015FY 2014FY 2013FY 2012FY 2011FY 2010
CurrencyUSDUSDUSDUSDUSDUSDUSDUSDUSDUSDUSDUSDUSDUSDUSDUSD
Period Ending2025-12-312024-12-312023-12-312022-12-312021-12-312020-12-312019-12-312018-12-312017-12-312016-12-312015-12-312014-12-312013-12-312012-12-312011-12-312010-12-31
Revenue$9.68M$135.16M$91.37M$53.91M$200.58M$853K$814K$955K$27.52M$1.05M$1.61M$50.85M$676K$2.66M$507K$1.24M
YoY Growth-92.8%47.9%69.5%-73.1%23414.3%4.8%-14.8%-96.5%2508.4%-34.3%-96.8%7422.8%-74.6%424.3%-59.2%-
Cost of Revenue$3.7M$0$0$0$0$74.88M$50.84M$101.18M$134.55M$119.53M$58.44M$38.45M$26.05M$34.14M$0$0
Gross Profit$5.98M$135.16M$91.37M$53.91M$200.58M-$74.03M-$50.02M-$100.23M-$107.03M-$118.48M-$56.83M$12.4M-$25.38M-$31.48M$507K$1.24M
Gross Margin61.8%100.0%100.0%100.0%100.0%-8678.9%-6145.2%-10495.1%-388.9%-11230.2%-3536.5%24.4%-3753.8%-1184.4%100.0%100.0%
Research and Development$134.85M$222.52M$220.57M$135.56M$82.28M$75.09M$50.84M$101.18M$134.55M$119.53M$58.44M$38.45M$26.05M$34.14M$24.17M$9.79M
Selling, General, and Administrative$59.39M$67.2M$61.84M$49.9M$46.32M$38.7M$35.74M$42.48M$48.23M$41.06M$23.11M$19.05M$15.05M$9.93M$5.58M$3.62M
Other-$3.7M$0$0$0$0-$75.09M-$50.9M$2.74M-$2.35M$571K$26K$310K-$225K$0$0$0
Total Operating Expenses$190.54M$289.72M$282.41M$185.46M$128.6M$38.7M$35.67M$143.66M$182.77M$160.59M$81.54M$57.5M$41.1M$44.07M$29.75M$13.4M
Operating Income (EBIT)-$184.56M-$154.56M-$191.04M-$131.56M$71.97M-$112.73M-$85.7M-$158.85M-$155.25M-$159.53M-$79.94M-$6.65M-$40.43M-$41.41M-$29.24M-$12.16M
Operating Margin-1905.8%-114.4%-209.1%-244.1%35.9%-13216.2%-10527.9%-16634.0%-564.2%-15121.8%-4974.3%-13.1%-5980.3%-1557.9%-5768.0%-978.4%
Interest Expense$0$0$0$0$0$0$0$3.7M$3.69M$863K$0$0$0$0$0$0
Interest Income$14.14M$25.82M$31.01M$6.35M$42K$1.37M$8.2M$6.39M$3.55M$1.42M$196K$79K$71K$5K$0$0
Other Income (Expense)-$16.27M$25.63M$30.56M$5.95M-$54K$1.87M$8.4M$2.74M-$2.35M$571K$26K$310K-$154K$5K$0$0
Income Before Tax (EBT)-$200.83M-$128.93M-$160.48M-$125.61M$71.92M-$110.86M-$77.3M-$156.12M-$157.6M-$158.96M-$79.91M-$6.34M-$40.58M-$41.41M-$29.24M-$12.16M
Income Tax Expense$43.26M-$6.62M-$13.45M-$8.66M$4.95M$283K$379K-$470K-$4.37M$1.14M$701K$811K$415K$6K$426K$320K
Net Income-$244.09M-$122.31M-$147.03M-$116.95M$66.97M-$111.14M-$77.68M-$155.65M-$153.24M-$160.11M-$80.61M-$7.15M-$41M-$41.41M-$29.67M-$12.48M
Net Income Margin-2520.6%-90.5%-160.9%-217.0%33.4%-13029.8%-9542.6%-16297.9%-556.8%-15176.1%-5016.3%-14.1%-6064.5%-1558.0%-5852.1%-1004.2%
Supplementary Data
EPS-4.53-2.27-2.76-2.471.51-2.78-1.95-3.93-4.07-4.66-2.66-0.29-2.20-2.84-1.68-0.71
Diluted EPS-4.53-2.27-2.76-2.471.38-2.78-1.95-3.93-4.07-4.66-2.66-0.29-2.20-2.84-1.68-0.71
Weighted Average OS53.83M53.77M53.22M47.37M44.23M39.91M39.88M39.56M37.65M34.35M30.33M24.67M18.61M14.59M17.68M17.68M
EBITDA-$199.93M-$128.04M-$159.55M-$124.86M$73.04M-$111.22M-$78.94M-$152.9M-$152.19M-$156.54M-$79.13M-$5.91M-$39.77M-$40.94M-$28.85M-$11.97M
EBITDA Margin-2064.6%-94.7%-174.6%-231.6%36.4%-13038.7%-9697.5%-16010.4%-553.0%-14837.6%-4924.1%-11.6%-5882.7%-1540.3%-5690.9%-963.1%
Balance Sheet
PeriodFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016FY 2015FY 2014FY 2013FY 2012FY 2011FY 2010
CurrencyUSDUSDUSDUSDUSDUSDUSDUSDUSDUSDUSDUSDUSDUSDUSDUSD
Period Ending2025-12-312024-12-312023-12-312022-12-312021-12-312020-12-312019-12-312018-12-312017-12-312016-12-312015-12-312014-12-312013-12-312012-12-312011-12-312010-12-31
Assets
Current Assets
Cash and Cash Equivalents$307.53M$471.39M$618.83M$710.41M$579.09M$295.38M$375.72M$427.66M$417.62M$386.92M$370.59M$293.58M$176.68M$124.86M$0$0
Short-Term Investments$0$0$0$0$0$0$0$0$0$0$0$0$0$0$0$0
Cash and Short-Term Investments$307.53M$471.39M$618.83M$710.41M$579.09M$295.38M$375.72M$427.66M$417.62M$386.92M$370.59M$293.58M$176.68M$124.86M$0$0
Accounts Receivable$0$0$5.16M$62K$13K$15K$68K$2K$240K$178K$509K$1.76M$58K$223K$0$0
Inventory$0$0$0$0$0$0$0$0-$240K-$178K-$509K-$1.76M-$58K-$223K$0$0
Other Current Assets$1.75M$1.17M$3.49M$1.71M$766K$1.35M$0$0$0$0$0$0$81K$73K$0$0
Total Current Assets$315.19M$485.41M$639.28M$719.1M$584.81M$299.28M$378.38M$431.39M$426.33M$391.36M$377.4M$299.27M$178.22M$125.84M$124K$0
Long-Term Assets
Property, Plant & Equipment Net$10.27M$13.79M$16M$8.01M$14.13M$20.36M$27.15M$52.84M$54.99M$56.45M$3.86M$3.12M$3.37M$3.39M$2.54M$2.4M
Goodwill$0$0$0$0$0$0$0$0$0$0$0$0$0$0$0$0
Intangible Assets$0$0$0$0$0$0$0$0$0$0$0$0$0$49K$70K$0
Long-Term Investments$860K$860K$0$0$0$0$0$4.06M$4.06M$4.06M$0$0$0-$122K$0$0
Deferred Tax Assets$0$43.24M$33.89M$18.2M$7.07M$11.64M$9.96M$9.7M$8.11M$5.91M$2.85M$1.72M$816K$73K$0$0
Other Long-Term Assets$482K$3.81M$7.21M$12.72M$3.35M$1.69M$3.79M$4.87M$6.9M$6.25M$1.12M$0$0$49K$885K$900K
Total Long-Term Assets$11.61M$61.7M$57.1M$38.94M$24.56M$33.69M$40.89M$67.41M$70M$68.61M$7.83M$4.84M$4.19M$3.44M$3.49M$3.3M
Other Assets$0$0$0$0$0$0$0$0$0$0$0$0$0$0$0$0
Total Assets$326.8M$547.11M$696.38M$758.03M$609.37M$332.98M$419.27M$498.8M$496.33M$459.98M$385.24M$304.12M$182.41M$129.28M$3.62M$3.3M
Liabilities
Current Liabilities
Accounts Payable$5.88M$7.77M$25.39M$9.27M$3.69M$4.12M$1.24M$1.47M$13.63M$13.07M$4.52M$4.72M$1.79M$0$380K$100K
Short-Term Debt$2.89M$0$0$0$0$0$0$0$0$0$0$0$0$0$0$0
Current Income Tax Payable$0$0$0$0$0$36K$5K$54K$311K$378K$98K$57K$184K$27K$0$500K
Current Unearned Revenue$2.66M$8.85M$0$11.44M$7.66M$0$0$110.24M-$857K$363K$284K$0$0$0$0$0
Other Current Liabilities$29.42M$1.38M$2.13M$503K$405K$516K$322K$837K$1.72M$1.87M$804K$725K$658K$51K$288K$1.2M
Total Current Liabilities$40.84M$48.5M$56.89M$50.15M$33.45M$25.85M$17.71M$14.93M$37.37M$41.08M$22.22M$12.04M$7.41M$1.74M$8.4M$1.8M
Long-Term Liabilities
Long-Term Debt$5.49M$0$0$0$0$0$0$0$0$0$0$0$0$0$0$0
Long-Term Unearned Revenue$0$3.45M$67.41M$85.29M$102.93M$110.24M$110.24M$110.24M$254K$2.08M$2.13M$0$0$0$0$1.4M
Long-Term Deferred Tax Liabilities$0$0$0$0$0$0$0-$49.9M-$254K-$2.08M$0$1.72M$0$0$0$0
Other Long-Term Liabilities-$5.49M$0$0$553K$553K$553K$553K$110.97M$254K$2.18M$2.35M$468K$1.73M$1.05M$1.65M$0
Total Long-Term Liabilities$5.49M$11.68M$78.13M$85.85M$109.87M$123.12M$128.63M$160.87M$51.77M$53.5M$2.35M$2.19M$1.73M$1.05M$1.65M$1.4M
Other Liabilities$0$0$0$0$0$0$0$0$0$0$0$0$0$0$0$0
Total Liabilities$46.33M$60.18M$135.02M$135.99M$143.32M$148.97M$146.35M$175.8M$89.14M$94.57M$24.57M$14.23M$9.14M$2.8M$10.05M$3.2M
Stockholders' Equity
Preferred Stock$0$0$0$0$0$0$0$0$0$0$0$0$0$0$0$0
Common Stock$538K$538K$537K$521K$466K$399K$399K$399K$385K$348K$317K$274K$219K$177K$0$0
Retained Earnings-$1.35B-$1.1B-$980.03M-$833M-$716.05M-$783.03M-$671.88M-$598M-$442.35M-$289.21M-$129.1M-$48.49M-$41.34M-$345K$0-$12.5M
Comprehensive Income & Other$0$0$0$0$0$0$0-$10.5M-$7.74M-$7.67M-$5.34M-$4.71M-$4.29M-$3.71M-$568K$12.6M
Other Stockholders' Equity$1.63B$1.59B$1.54B$1.45B$1.18B$966.64M$944.41M$920.59M$849.15M$654.27M$489.45M$338.11M$214.39M$126.65M-$6.44M$12.6M
Total Equity$280.47M$486.93M$561.37M$622.04M$466.04M$184.01M$272.92M$323M$407.19M$365.4M$360.67M$289.89M$173.27M$126.48M-$6.44M$100K
Minority Interest$0$0$0$0$0$0$0$0$0$0$0$0$0$0$0$0
Total Liabilities and Equity$326.8M$547.11M$696.38M$758.03M$609.37M$332.98M$419.27M$498.8M$496.33M$459.98M$385.24M$304.12M$182.41M$129.28M$3.62M$3.3M
Supplementary Data
Total Debt$13.86M$10.84M$11.84M$6.47M$12.33M$17.84M$22.94M$51.55M$52.25M$51.32M$0$0$0$0$0$0
Net Debt-$293.67M-$460.55M-$607M-$703.93M-$566.77M-$277.54M-$352.78M-$376.11M-$365.37M-$335.6M-$370.59M-$293.58M-$176.68M-$124.86M$0$0
Cash Flow Statement
PeriodFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016FY 2015FY 2014FY 2013FY 2012FY 2011FY 2010
CurrencyUSDUSDUSDUSDUSDUSDUSDUSDUSDUSDUSDUSDUSDUSDUSDUSD
Period Ending2025-12-312024-12-312023-12-312022-12-312021-12-312020-12-312019-12-312018-12-312017-12-312016-12-312015-12-312014-12-312013-12-312012-12-312011-12-312010-12-31
Operating Activities
Net Income-$244.09M-$122.31M-$147.03M-$116.95M$66.97M-$111.14M-$77.68M-$155.65M-$153.24M-$160.11M-$80.61M-$7.15M-$41M-$41.41M-$29.67M-$12.48M
Depreciation & Amortization$895K$893K$928K$744K$1.11M$1.51M$6.82M$3.22M$3.07M$2.43M$806K$743K$660K$468K$391K$191K
Deferred Income Tax$43.24M-$9.35M-$15.69M-$11.13M$4.57M-$1.69M-$1.25M-$1.59M-$2.2M-$3.25M-$963K-$990K-$538K$0$0$0
Stock-Based Compensation$37.64M$45.96M$40.91M$31.32M$24.66M$22.01M$23.59M$27.01M$26.76M$24.93M$10.41M$5.6M$3.13M$6.1M$2.97M$1.6M
Changes in Working Capital:
  Accounts Receivable$0$5.16M-$5.16M$0$15K$53K$0$238K-$62K$331K$1.25M-$1.7M$165K-$223K-$146K$0
  Inventory$0$0-$8.9M$0$0$0$0$9.6M-$396.2M-$346.92M-$356.12M-$289.59M-$171.54M-$124.56M$8.28M$0
  Accounts Payable-$15.78M-$18.3M$22.86M$11.87M-$492K$7.73M-$78K-$25.63M$147K$15.19M$11.16M$5.43M$6.23M-$6.54M$6.76M$1.69M
  Other Working Capital$11.6M-$54.8M-$29.33M-$30.67M-$9.93M-$4.3M-$4.37M$110.24M$388.96M$350.29M$355.19M$287.24M$170.82M$124.1M-$8.28M-$83K
Total Working Capital Change-$4.17M-$67.94M-$20.53M-$18.8M-$10.4M$3.48M-$4.45M$94.45M-$7.16M$18.89M$11.47M$1.38M$5.68M-$7.23M$6.61M$1.61M
Other Non-Cash Items$2.91M$2.69M$7.5M$6M$5.69M$5.46M$0$4.28M$1.59M-$156K-$3.57M-$261K-$29K-$1.13M$0$0
Net Cash from Operating-$163.58M-$150.05M-$133.91M-$108.82M$92.61M-$80.36M-$52.97M-$28.28M-$131.18M-$117.27M-$62.45M-$683K-$32.1M-$42.07M-$19.7M-$9.08M
Investing Activities
Capital Expenditures-$138K-$298K-$2.81M-$464K-$575K-$196K-$555K-$1.77M-$3.63M-$16.64M-$1.38M-$526K-$564K-$1.3M-$595K-$2.61M
Acquisitions$0$0$0$0$0$0$0$39K$105K$0$0$0$0$0$0$0
Purchases of Investments$0$0$0$0$0$0$0$0$0$0$0$0$0$0$0$0
Sales of Investments$0$0$0$0$0$0$0$0$0$0$0$0$0$0$0$0
Other Investing Activities$0$0$37K$0$0$0$8K$39K$105K$0$0$27K$29K$0$0$0
Net Cash from Investing-$138K-$298K-$2.77M-$464K-$575K-$196K-$547K-$1.73M-$3.52M-$16.64M-$1.38M-$499K-$535K-$1.3M-$595K-$2.61M
Financing Activities
Debt Repaid-------$4.4M$2.76M$169K------
Common Stock Issuance-$139K$0$23.58M$223.62M$174.79M$0$0$39.76M$150.32M$128.78M$131.34M$117.35M$84.53M$26M$0$0
Common Stock Repurchases$0-$353K$0$0$0$0$0$0$0$0$0$0$0$0$0$0
Dividends Paid$0$0$0$0$0$0$0$0$0$0$0$0$0$0$0$0
Other Financing Activities$0$1.91M$21.52M$17.84M$15.54M$215K$228K$4.69M$17.84M$25.7M$9.5M$736K-$84K$142.23M$20.29M$11.69M
Net Cash from Financing-$139K$1.55M$45.1M$241.46M$190.33M$215K$228K$40.04M$165.4M$154.31M$140.84M$118.08M$84.45M$168.23M$20.29M$11.69M
Forex Effect$0$0$0$0$0$0$0$0$0$0$0$0$0$0$0$0
Net Change in Cash-$163.86M-$148.79M-$91.58M$132.17M$282.36M-$80.34M-$53.29M$10.04M$30.7M$20.39M$77.01M$116.9M$51.82M$124.86M$0$0
Supplementary Data
Operating Cash Flow-$163.58M-$150.05M-$133.91M-$108.82M$92.61M-$80.36M-$52.97M-$28.28M-$131.18M-$117.27M-$62.45M-$683K-$32.1M-$42.07M-$19.7M-$9.08M
Capital Expenditure-$138K-$298K-$2.81M-$464K-$575K-$196K-$555K-$1.77M-$3.63M-$16.64M-$1.38M-$526K-$564K-$1.3M-$595K-$2.61M
Free Cash Flow-$163.72M-$150.35M-$136.72M-$109.28M$92.03M-$80.56M-$53.52M-$30.04M-$134.81M-$133.91M-$63.84M-$1.21M-$32.66M-$43.37M-$20.29M-$11.69M
Cash at Beginning$472.25M$621.04M$712.62M$580.45M$298.08M$378.43M$431.71M$421.68M$390.98M$370.59M$293.58M$176.68M$124.86M$0$0$0
Cash at End$308.39M$472.25M$621.04M$712.62M$580.45M$298.08M$378.43M$431.71M$421.68M$390.98M$370.59M$293.58M$176.68M$124.86M$0$0