Protagonist Therapeutics, Inc (PTGX)
Protagonist Therapeutics, Inc. is a biopharmaceutical firm dedicated to discovering and advancing peptide-based therapies. Their research primarily focuses on treatments for hematological and blood conditions, as well as inflammatory and immune-mediated disorders. The company's pipeline features rusfertide (PTG-300), an injectable hepcidin mimetic currently undergoing Phase II clinical trials for the management of polycythemia vera, hereditary hemochromatosis, and other blood-related ailments. Also in Phase II development is PN-943, an oral peptide engineered as a specific antagonist of alpha-4-beta-7 integrin, intended for addressing inflammatory bowel disease (IBD). Furthermore, they are progressing PN-235, an orally administered antagonist specifically targeting the interleukin-23 receptor, designed for both IBD and various non-IBD therapeutic applications. Protagonist Therapeutics maintains a licensing and collaborative agreement with Janssen Biotech, Inc. Founded in 2006, the company's headquarters are located in Newark, California.
Sector: Pharmaceutical Preparations
Industry: Biotechnology
Protagonist Therapeutics, Inc.
NASDAQ:PTGXHealthcare · Biotechnology
+0.35%$144.85
AH$144.85+0.00%vs close
Mkt Cap$9.37B
Float61.21M
O/S64.71M
Vol
$ Vol
RVOL
Inst Own-
SI16.8%
Earnings
Dilution
Financials Summary
Revenue$46.02M
Net Income-$130.15M
Total Assets$669.89M
Free Cash Flow$56.08M
Debt & Equity
Debt 2%
Equity 98%
Total Debt$10.32M
Total Equity$614.71M
Shares Outstanding
Short Interest
Split History
No splits on record
Nothing in PTGX's public trading history: no forward or reverse split has affected the share count.
Balance Sheet Details
Assets$669.89M
Liabilities$55.19M
Accounts Receivable$4.5M
Accounts Payable$5.34M
Inventory$0
PP&E (Net)$11.69M
Goodwill$0
Intangible Assets$0
Income Statement
| Period | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 | FY 2015 | FY 2014 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Currency | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD |
| Period Ending | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | 2020-12-31 | 2019-12-31 | 2018-12-31 | 2017-12-31 | 2016-12-31 | 2015-12-31 | 2014-12-31 |
| Revenue | $46.02M | $434.43M | $60M | $26.58M | $27.36M | $28.63M | $231K | $30.93M | $20.06M | $0 | $0 | $0 |
| YoY Growth | -89.4% | 624.1% | 125.7% | -2.8% | -4.4% | 12293.1% | -99.3% | 54.1% | - | - | - | - |
| Cost of Revenue | $1.23M | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $317K | $247K | $0 |
| Gross Profit | $44.79M | $434.43M | $60M | $26.58M | $27.36M | $28.63M | $231K | $30.93M | $20.06M | -$317K | -$247K | $0 |
| Gross Margin | 97.3% | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% | - | - | - |
| Research and Development | $159.29M | $138.13M | $120.16M | $126.22M | $126.01M | $75.98M | $65M | $59.5M | $46.18M | $25.7M | $11.83M | $7.46M |
| Selling, General, and Administrative | $44.85M | $43.46M | $33.49M | $31.74M | $27.2M | $18.64M | $15.75M | $13.7M | $11.78M | $6.96M | $2.96M | $1.86M |
| Other | -$1.23M | $0 | $0 | $0 | $0 | -$1.48M | -$1K | $0 | $0 | -$34K | $0 | $0 |
| Total Operating Expenses | $202.92M | $181.59M | $153.65M | $157.95M | $153.2M | $93.14M | $80.75M | $73.19M | $57.96M | $32.67M | $14.79M | $9.32M |
| Operating Income (EBIT) | -$158.13M | $252.84M | -$93.65M | -$131.37M | -$125.84M | -$64.52M | -$80.52M | -$42.27M | -$37.9M | -$32.67M | -$14.79M | -$9.32M |
| Operating Margin | -343.6% | 58.2% | -156.1% | -494.2% | -460.0% | -225.4% | -34857.6% | -136.7% | -188.9% | - | - | - |
| Interest Expense | $0 | $0 | $0 | $0 | $0 | $598K | $169K | $0 | $0 | $0 | $0 | $0 |
| Interest Income | $28.79M | $26.32M | $14.9M | $4.06M | $443K | $900K | $2.81M | $2.57M | $948K | $242K | $19K | $16K |
| Other Income (Expense) | $28.82M | $26.57M | $14.7M | $3.98M | $294K | -$329K | $2.64M | $2.55M | $940K | -$4.51M | -$64K | -$1.75M |
| Income Before Tax (EBT) | -$129.31M | $279.41M | -$78.95M | -$127.39M | -$125.55M | -$64.84M | -$77.88M | -$39.72M | -$36.96M | -$37.18M | -$14.86M | -$11.07M |
| Income Tax Expense | $838K | $4.22M | $0 | $0 | $0 | $1.3M | -$691K | -$799K | $0 | $0 | $64K | $0 |
| Net Income | -$130.15M | $275.19M | -$78.95M | -$127.39M | -$125.55M | -$66.15M | -$77.19M | -$38.92M | -$36.96M | -$37.18M | -$14.86M | -$11.07M |
| Net Income Margin | -282.8% | 63.3% | -131.6% | -479.3% | -458.9% | -231.1% | -33414.3% | -125.9% | -184.2% | - | - | - |
| Supplementary Data | ||||||||||||
| EPS | -2.05 | 4.47 | -1.39 | -2.52 | -2.65 | -1.92 | -2.98 | -1.74 | -2.09 | -5.72 | -2.52 | -1.88 |
| Diluted EPS | -2.05 | 4.23 | -1.39 | -2.52 | -2.65 | -1.92 | -2.98 | -1.74 | -2.09 | -5.72 | -2.52 | -1.88 |
| Weighted Average OS | 63.57M | 61.57M | 56.76M | 49.04M | 46.32M | 34.40M | 25.89M | 22.36M | 17.69M | 6.50M | 5.88M | 5.88M |
| EBITDA | -$128.03M | $282.37M | -$75.64M | -$124.02M | -$122.78M | -$61.79M | -$75.19M | -$39.2M | -$36.55M | -$32.35M | -$14.55M | -$9.06M |
| EBITDA Margin | -278.2% | 65.0% | -126.1% | -466.6% | -448.8% | -215.8% | -32547.6% | -126.7% | -182.2% | - | - | - |
Balance Sheet
| Period | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 | FY 2015 | FY 2014 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Currency | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD |
| Period Ending | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | 2020-12-31 | 2019-12-31 | 2018-12-31 | 2017-12-31 | 2016-12-31 | 2015-12-31 | 2014-12-31 |
| Assets | ||||||||||||
| Current Assets | ||||||||||||
| Cash and Cash Equivalents | $128.39M | $97.25M | $186.73M | $125.74M | $123.67M | $117.36M | $33.01M | $82.23M | $106.03M | $21.08M | $4.05M | $9.32M |
| Short-Term Investments | $438.97M | $321.66M | $154.89M | $111.61M | $203.24M | $188.45M | $100.01M | $46.62M | $37.97M | $56.52M | $7.87M | $0 |
| Cash and Short-Term Investments | $567.36M | $418.91M | $341.62M | $237.35M | $326.9M | $305.81M | $133.02M | $128.85M | $144M | $77.6M | $11.92M | $9.32M |
| Accounts Receivable | $4.5M | $168.49M | $10.33M | $52K | $5.33M | $3.82M | $6.75M | $4.59M | $1.82M | $2.24M | $715K | $523K |
| Inventory | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $2.14M | -$8.75M | -$7.65M | $0 | $10K |
| Other Current Assets | $0 | $0 | $0 | $0 | $0 | $10K | $754K | -$205K | $10.24M | $8.16M | $315K | $56K |
| Total Current Assets | $577.57M | $591.64M | $355.58M | $243.08M | $340.74M | $315.61M | $145.31M | $137.5M | $150.95M | $83.24M | $14.21M | $9.91M |
| Long-Term Assets | ||||||||||||
| Property, Plant & Equipment Net | $11.69M | $12.61M | $2.15M | $4.63M | $6.73M | $6.41M | $7.72M | $861K | $879K | $562K | $609K | $415K |
| Goodwill | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Intangible Assets | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Long-Term Investments | $78.92M | $140.25M | $0 | $0 | $0 | $2M | $0 | $450K | $11.46M | $10.15M | $30K | $0 |
| Deferred Tax Assets | $1.71M | $0 | $0 | $0 | $0 | $0 | $1.43M | $658K | $0 | $0 | $0 | $0 |
| Other Long-Term Assets | $0 | $225K | $225K | $225K | $225K | $450K | $450K | $450K | $450K | $34K | $0 | $0 |
| Total Long-Term Assets | $92.32M | $153.08M | $2.37M | $4.85M | $6.96M | $8.86M | $9.61M | $1.97M | $12.79M | $10.75M | $639K | $415K |
| Other Assets | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Total Assets | $669.89M | $744.73M | $357.95M | $247.93M | $347.69M | $324.47M | $154.92M | $139.47M | $163.73M | $93.99M | $14.85M | $10.33M |
| Liabilities | ||||||||||||
| Current Liabilities | ||||||||||||
| Accounts Payable | $5.34M | $1.61M | $772K | $3.64M | $1.6M | $3.08M | $2.79M | $5.71M | $1.26M | $1.16M | $1.25M | $349K |
| Short-Term Debt | $2.28M | $510K | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Current Income Tax Payable | $0 | $2.69M | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Current Unearned Revenue | $9.55M | $18.89M | $0 | $69K | $2.5M | $17.21M | $19M | $8.22M | $31.75M | $0 | $0 | $0 |
| Other Current Liabilities | $15.51M | $12.62M | $6.79M | $4.97M | $7.13M | $6.41M | $4.64M | $9.5M | $6.83M | $120K | $149K | $0 |
| Total Current Liabilities | $45.44M | $47.4M | $21.27M | $31.18M | $44.02M | $40.24M | $35.41M | $26.16M | $42.55M | $6.43M | $3.13M | $1.35M |
| Long-Term Liabilities | ||||||||||||
| Long-Term Debt | $0 | $0 | $0 | $0 | $0 | $0 | $9.79M | $0 | $0 | $0 | $0 | $0 |
| Long-Term Unearned Revenue | $0 | $0 | $0 | $0 | $0 | $0 | $23.79M | $0 | $0 | $0 | $0 | $0 |
| Long-Term Deferred Tax Liabilities | $1.71M | $0 | $221K | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Other Long-Term Liabilities | $0 | $11.68M | -$221K | $0 | $0 | $121K | $0 | $799K | $547K | $0 | $2.12M | $1.02M |
| Total Long-Term Liabilities | $9.74M | $22.03M | $0 | $1.14M | $3.66M | $4.62M | $39.55M | $799K | $547K | $0 | $2.12M | $1.02M |
| Other Liabilities | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Total Liabilities | $55.19M | $69.43M | $21.27M | $32.32M | $47.67M | $44.86M | $74.95M | $26.96M | $43.1M | $6.43M | $5.25M | $2.37M |
| Stockholders' Equity | ||||||||||||
| Preferred Stock | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $93.99M | $37M | $20.58M |
| Common Stock | $1K | $1K | $1K | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Retained Earnings | -$470.67M | -$340.52M | -$615.71M | -$536.75M | -$409.36M | -$283.81M | -$217.66M | -$140.47M | -$101.55M | -$64.59M | -$27.42M | -$12.56M |
| Comprehensive Income & Other | $641K | -$82K | -$105K | -$359K | -$299K | $28K | -$221K | -$233K | -$6K | -$245K | -$102K | -$100K |
| Other Stockholders' Equity | $1.09B | $1.02B | $952.39M | $752.36M | $709.38M | $563.42M | $297.63M | $0 | $0 | $0 | $37.01M | $20.51M |
| Total Equity | $614.71M | $675.29M | $336.68M | $215.61M | $300.02M | $279.61M | $79.96M | -$140.47M | -$101.55M | -$64.59M | $9.6M | $7.96M |
| Minority Interest | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Total Liabilities and Equity | $669.89M | $744.73M | $357.95M | $247.93M | $347.69M | $324.47M | $154.92M | -$113.52M | -$58.45M | -$58.16M | $14.85M | $10.33M |
| Supplementary Data | ||||||||||||
| Total Debt | $10.32M | $10.87M | $1.14M | $3.66M | $5.86M | $5.96M | $17.01M | $0 | $0 | $0 | $0 | $0 |
| Net Debt | -$118.07M | -$86.38M | -$185.59M | -$122.09M | -$117.81M | -$111.4M | -$15.99M | -$82.23M | -$106.03M | -$21.08M | -$4.05M | -$9.32M |
Cash Flow Statement
| Period | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 | FY 2015 | FY 2014 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Currency | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD |
| Period Ending | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | 2020-12-31 | 2019-12-31 | 2018-12-31 | 2017-12-31 | 2016-12-31 | 2015-12-31 | 2014-12-31 |
| Operating Activities | ||||||||||||
| Net Income | -$130.15M | $275.19M | -$78.95M | -$127.39M | -$125.55M | -$66.15M | -$77.19M | -$38.92M | -$36.96M | -$37.18M | -$14.86M | -$11.07M |
| Depreciation & Amortization | $1.28M | $2.96M | $3.31M | $3.37M | $2.77M | $2.72M | $2.52M | $527K | $406K | $317K | $247K | $258K |
| Deferred Income Tax | $0 | $0 | $0 | $0 | $0 | $1.44M | -$775K | -$658K | $0 | $151K | -$8K | $0 |
| Stock-Based Compensation | $45.97M | $37.55M | $29.29M | $24.2M | $16.39M | $7.9M | $8.35M | $6.92M | $4.24M | $2.13M | $99K | $42K |
| Changes in Working Capital: | ||||||||||||
| Accounts Receivable | $164.88M | -$155M | -$9.99M | $4.24M | -$915K | $3.34M | -$757K | -$2.77M | -$1.82M | -$1.59M | -$192K | $0 |
| Inventory | $0 | $0 | $0 | -$4.24M | $915K | -$3.34M | $757K | $3.85M | $5.53M | $0 | $0 | $0 |
| Accounts Payable | $3.72M | $842K | -$2.87M | $2.04M | -$1.39M | $309K | -$3M | $4.43M | $91K | -$115K | $898K | $179K |
| Other Working Capital | -$22.39M | $31.55M | -$6.65M | -$9.81M | -$1.92M | -$19.32M | $29.14M | -$23.53M | $31.75M | $3K | -$846K | $1.08M |
| Total Working Capital Change | $146.21M | -$122.61M | -$19.51M | -$7.77M | -$3.31M | -$19.02M | $26.14M | -$18.02M | $35.56M | -$112K | $52K | $1.26M |
| Other Non-Cash Items | -$5.64M | -$8.94M | -$4.38M | -$549K | $1.83M | $622K | -$586K | $206K | $625K | $4.72M | $83K | $1.77M |
| Net Cash from Operating | $57.67M | $184.15M | -$70.24M | -$108.14M | -$107.86M | -$72.48M | -$41.53M | -$49.95M | $3.87M | -$29.97M | -$14.38M | -$7.74M |
| Investing Activities | ||||||||||||
| Capital Expenditures | -$1.59M | -$1.35M | -$609K | -$795K | -$1.1M | -$471K | -$967K | -$486K | -$666K | -$379K | -$399K | -$299K |
| Acquisitions | $0 | $0 | $0 | -$91.47M | $14.76M | $90.49M | $52.74M | $0 | $0 | $32K | $0 | $0 |
| Purchases of Investments | -$546.59M | -$621.7M | -$191.04M | -$214.87M | -$286.59M | -$280.03M | -$166.94M | -$71.06M | -$39.55M | -$73.17M | -$7.87M | $0 |
| Sales of Investments | $498.84M | $323.57M | $152.4M | $307.14M | $271.83M | $189.53M | $114.19M | $73.76M | $56.03M | $14.19M | $0 | $0 |
| Other Investing Activities | $0 | $0 | $0 | $91.47M | -$14.76M | -$90.49M | -$52.74M | $2.7M | $16.49M | $32K | -$7.87M | $0 |
| Net Cash from Investing | -$49.33M | -$299.48M | -$39.26M | $91.47M | -$15.86M | -$90.97M | -$53.71M | $2.21M | $15.82M | -$59.33M | -$8.26M | -$299K |
| Financing Activities | ||||||||||||
| Debt Repaid | - | - | - | - | - | $10.52M | -$9.77M | - | - | - | - | - |
| Common Stock Issuance | $23.34M | $26.45M | $132.1M | $14.55M | $123.83M | $255.37M | $34.49M | $23.18M | $64.55M | $83.65M | $17.42M | $0 |
| Common Stock Repurchases | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Dividends Paid | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Other Financing Activities | -$479K | -$600K | $38.38M | $4.29M | $6.09M | $2.79M | $1.78M | $934K | $1.01M | $151K | $57K | $3K |
| Net Cash from Financing | $22.86M | $25.85M | $170.48M | $18.84M | $129.92M | $247.63M | $46.04M | $24.11M | $65.55M | $106.31M | $17.42M | $9M |
| Forex Effect | -$62K | $0 | $0 | -$90K | -$126K | $175K | -$26K | -$177K | $146K | $22K | -$39K | -$97K |
| Net Change in Cash | $31.14M | -$89.48M | $60.98M | $2.08M | $6.07M | $84.35M | -$49.23M | -$23.8M | $85.39M | $17.03M | -$5.27M | $864K |
| Supplementary Data | ||||||||||||
| Operating Cash Flow | $57.67M | $184.15M | -$70.24M | -$108.14M | -$107.86M | -$72.48M | -$41.53M | -$49.95M | $3.87M | -$29.97M | -$14.38M | -$7.74M |
| Capital Expenditure | -$1.59M | -$1.35M | -$609K | -$795K | -$1.1M | -$471K | -$967K | -$486K | -$666K | -$379K | -$399K | -$299K |
| Free Cash Flow | $56.08M | $182.8M | -$70.84M | -$108.93M | -$108.97M | -$72.95M | -$42.49M | -$50.43M | $3.21M | -$30.35M | -$14.78M | -$8.04M |
| Cash at Beginning | $97.25M | $186.95M | $125.97M | $123.89M | $117.82M | $33.47M | $82.69M | $106.49M | $21.09M | $4.05M | $9.32M | $8.46M |
| Cash at End | $128.39M | $97.47M | $186.95M | $125.97M | $123.89M | $117.82M | $33.47M | $82.69M | $106.49M | $21.08M | $4.05M | $9.32M |