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Relay Therapeutics, Inc. (RLAY)

Relay Therapeutics, Inc. is a precision medicine company currently engaged in clinical trials. Its central mission involves revolutionizing the drug discovery process, with a particular focus on enhancing the creation of small molecule therapies for specific types of cancer and genetic conditions. The company's pipeline features several promising drug candidates: RLY-4008, an orally administered small molecule designed to inhibit fibroblast growth factor receptor 2 (FGFR2), which is undergoing its initial human trials for patients with advanced or metastatic solid tumors exhibiting FGFR2 alterations; RLY-2608, a leading program targeting mutant phosphoinositide 3 kinase alpha (PI3Ka); and RLY-1971, another oral small molecule, an inhibitor of SHP2 (protein tyrosine phosphatase Src homology region 2 domain-containing phosphatase-2), currently in Phase 1 trials for individuals with advanced solid tumors. Relay Therapeutics has established strategic partnerships, including a collaboration with D. E. Shaw Research, LLC, which utilizes computational modeling to analyze protein motion for the identification and development of therapeutic compounds. Furthermore, an agreement with Genentech, Inc. supports the development and commercialization of RLY-1971. Founded in 2015 as Allostery, Inc., the company rebranded to Relay Therapeutics, Inc. in December of that year and maintains its headquarters in Cambridge, Massachusetts.

Sector: Biological Products, (No Diagnostic Substances)

Industry: Biotechnology

Relay Therapeutics, Inc. logo

Relay Therapeutics, Inc.

NASDAQ:RLAYHealthcare
-5.75%$18.35
AH$18.22-0.69%vs close
Mkt Cap$4.02B
Float157.61M
O/S219.14M
Vol
$ Vol
RVOL
Inst Own-
SI27.9%
Earnings
Dilution
Phase Distribution
5 lead-sponsored trials·4 active·1 completed
Phase 13
Phase 21
Phase 31
(2 more as collaborator)
Status Overview
Recruiting4
Completed1

Trials need funding. See this company's dilution risk and cash position.

Clinical Trials
Sponsor role
Status
Phase
  • Phase 3
    Recruiting

    Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer

    Zovegalisib, Capivasertib

    PIK3CA Mutation, HER2- Negative Breast Cancer +4

    Enrollment
    540
    Start
    Aug 2025
    Primary Completion
    Apr 2028est.
    Completion
    Dec 2031est.
    NCT06982521
  • Phase 2
    Recruiting

    A Phase 2 Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, in Adults and Children With PIK3CA Related Overgrowth Spectrum and Malformations Driven by PIK3CA Mutation (The ReInspire Study)

    RLY-2608, Placebo

    PIK3CA-Related Overgrowth Spectrum (PROS), Lymphatic Malformations +6

    Enrollment
    277
    Start
    Jun 2025
    Primary Completion
    Jul 2031est.
    Completion
    Oct 2031est.
    NCT06789913
  • Phase 1
    Recruiting

    First-in-Human Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, as a Single Agent in Patients With Advanced Solid Tumors and in Combination With Endocrine Therapy +/- a CDK4/6 or CDK4 Inhibitor in Patients With Advanced Solid Tumors or Advanced Breast Cancer

    RLY-2608, Fulvestrant

    PIK3CA Mutation, Solid Tumor, Adult +5

    Enrollment
    930
    Start
    Dec 2021
    Primary Completion
    Apr 2027est.
    Completion
    Apr 2027est.
    NCT05216432
  • Phase 1
    Completed

    First-in-Human Study of RLY-5836 in Advanced Breast Cancer and Other Solid Tumors

    RLY-5836, Fulvestrant

    PIK3CA Mutation, Solid Tumor, Adult +6

    Enrollment
    41
    Start
    Mar 2023
    Primary Completion
    Mar 2025
    Completion
    Apr 2025
    NCT05759949
  • Phase 1
    Recruiting

    A First-in-human Study of RLY-8161 in Advanced NRAS-Mutant Solid Tumors

    RLY-8161

    Advanced NRAS-Mutant Melanoma, Advanced NRAS-Mutant Solid Tumors +9

    Enrollment
    35
    Start
    Mar 2026
    Primary Completion
    Dec 2027est.
    Completion
    Dec 2029est.
    NCT07584226