Relay Therapeutics, Inc. (RLAY)
Relay Therapeutics, Inc. is a precision medicine company currently engaged in clinical trials. Its central mission involves revolutionizing the drug discovery process, with a particular focus on enhancing the creation of small molecule therapies for specific types of cancer and genetic conditions. The company's pipeline features several promising drug candidates: RLY-4008, an orally administered small molecule designed to inhibit fibroblast growth factor receptor 2 (FGFR2), which is undergoing its initial human trials for patients with advanced or metastatic solid tumors exhibiting FGFR2 alterations; RLY-2608, a leading program targeting mutant phosphoinositide 3 kinase alpha (PI3Ka); and RLY-1971, another oral small molecule, an inhibitor of SHP2 (protein tyrosine phosphatase Src homology region 2 domain-containing phosphatase-2), currently in Phase 1 trials for individuals with advanced solid tumors. Relay Therapeutics has established strategic partnerships, including a collaboration with D. E. Shaw Research, LLC, which utilizes computational modeling to analyze protein motion for the identification and development of therapeutic compounds. Furthermore, an agreement with Genentech, Inc. supports the development and commercialization of RLY-1971. Founded in 2015 as Allostery, Inc., the company rebranded to Relay Therapeutics, Inc. in December of that year and maintains its headquarters in Cambridge, Massachusetts.
Sector: Biological Products, (No Diagnostic Substances)
Industry: Biotechnology
Relay Therapeutics, Inc.
Trials need funding. See this company's dilution risk and cash position.
- Phase 3Recruiting
Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer
Zovegalisib, Capivasertib
PIK3CA Mutation, HER2- Negative Breast Cancer +4
NCT06982521Enrollment540StartAug 2025Primary CompletionApr 2028est.CompletionDec 2031est. - Phase 2Recruiting
A Phase 2 Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, in Adults and Children With PIK3CA Related Overgrowth Spectrum and Malformations Driven by PIK3CA Mutation (The ReInspire Study)
RLY-2608, Placebo
PIK3CA-Related Overgrowth Spectrum (PROS), Lymphatic Malformations +6
NCT06789913Enrollment277StartJun 2025Primary CompletionJul 2031est.CompletionOct 2031est. - Phase 1Recruiting
First-in-Human Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, as a Single Agent in Patients With Advanced Solid Tumors and in Combination With Endocrine Therapy +/- a CDK4/6 or CDK4 Inhibitor in Patients With Advanced Solid Tumors or Advanced Breast Cancer
RLY-2608, Fulvestrant
PIK3CA Mutation, Solid Tumor, Adult +5
NCT05216432Enrollment930StartDec 2021Primary CompletionApr 2027est.CompletionApr 2027est. - Phase 1Completed
First-in-Human Study of RLY-5836 in Advanced Breast Cancer and Other Solid Tumors
RLY-5836, Fulvestrant
PIK3CA Mutation, Solid Tumor, Adult +6
NCT05759949Enrollment41StartMar 2023Primary CompletionMar 2025CompletionApr 2025 - Phase 1Recruiting
A First-in-human Study of RLY-8161 in Advanced NRAS-Mutant Solid Tumors
RLY-8161
Advanced NRAS-Mutant Melanoma, Advanced NRAS-Mutant Solid Tumors +9
NCT07584226Enrollment35StartMar 2026Primary CompletionDec 2027est.CompletionDec 2029est.
| Drug / Therapy | Link | ||
|---|---|---|---|
| Phase 3 | Recruiting | Zovegalisib, Capivasertib | NCT06982521 |
| Phase 2 | Recruiting | RLY-2608, Placebo | NCT06789913 |
| Phase 1 | Recruiting | RLY-2608, Fulvestrant | NCT05216432 |
| Phase 1 | Completed | RLY-5836, Fulvestrant | NCT05759949 |
| Phase 1 | Recruiting | RLY-8161 | NCT07584226 |