Rallybio Corp (RLYB)
Rallybio Corporation is a clinical-stage biotechnology firm dedicated to discovering and bringing to market transformative therapies for individuals facing severe and uncommon illnesses. Its most advanced therapeutic candidate, RLYB212, is a monoclonal anti-HPA-1a antibody currently undergoing Phase II clinical trials. This candidate, along with RLYB211, is aimed at preventing fetal and neonatal alloimmune thrombocytopenia (FNAIT). The company's pipeline also includes RLYB114, a pegylated complement factor 5 (C5)-targeted Affibody molecule in preclinical development for addressing ophthalmic conditions driven by complement system activity. Furthermore, RLYB116, an inhibitor designed to target complement component 5 (C5) for various complement dysregulation disorders, has successfully completed its Phase 1 trial. Another preclinical antibody, RLYB332, is under investigation for treating severe anemia characterized by ineffective erythropoiesis and iron overload. Rallybio has established strategic collaborations to further its development efforts. It maintains an alliance with AbCellera for the identification, development, and commercialization of novel antibody-based therapeutics in rare diseases. Additionally, the firm partners with Exscientia on the creation of small molecule therapeutics for rare diseases, and with Johnson & Johnson to deliver therapeutic options to expectant mothers at risk of fetal and neonatal alloimmune thrombocytopenia. Established in 2018, Rallybio Corporation is headquartered in New Haven, Connecticut.
Sector: Pharmaceutical Preparations
Industry: Biotechnology
Rallybio Corporation
Trials need funding. See this company's dilution risk and cash position.
- Phase 2Terminated
Phase 2 Study on the Pharmacokinetics and Safety of RLYB212 in Pregnant Women at Higher Risk for HPA-1a Alloimmunization
Anti-(integrin beta-3) human monoclonal antibody
Fetal and Neonatal Alloimmune Thrombocytopenia
NCT06435845Enrollment1StartNov 2024Primary CompletionOct 2025CompletionOct 2025 - Phase 1Completed
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of RLYB116 in Healthy Participants
RLYB116 for Injection
Hematologic Diseases, Autoimmune Diseases
NCT06797375Enrollment16StartApr 2025Primary CompletionFeb 2026CompletionFeb 2026 - ObservationalCompleted
Study to Assess the Occurrence of HPA-1a Alloimmunization in Women With Higher Risk for Fetal and Neonatal Alloimmune Thrombocytopenia
Clinical data collection
Fetal and Neonatal Alloimmune Thrombocytopenia
NCT05345561Enrollment14,390StartMar 2022Primary CompletionJan 2025CompletionOct 2025
| Drug / Therapy | Link | ||
|---|---|---|---|
| Phase 2 | Terminated | Anti-(integrin beta-3) human monoclonal antibody | NCT06435845 |
| Phase 1 | Completed | RLYB116 for Injection | NCT06797375 |
| Observational | Completed | Clinical data collection | NCT05345561 |