RHYTHM PHARMACEUTICALS, INC. (RYTM)
Rhythm Pharmaceuticals, Inc. is a biopharmaceutical company with commercial products, dedicated to the discovery, development, and market launch of therapies addressing rare genetic conditions that cause obesity. Its leading pharmaceutical, IMCIVREE, functions as a powerful agonist of the melanocortin-4 receptor (MC4R). This medication is indicated for treating obesity stemming from deficiencies in pro-opiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1 (PCSK1), or the leptin receptor (LEPR), alongside its use in patients with Bardet-Biedl and Alström syndromes. Furthermore, the company is progressing setmelanotide (the active compound in IMCIVREE) through Phase II clinical trials. These studies are evaluating its potential for a broader spectrum of applications, including obesity caused by heterozygous POMC or LEPR deficiencies, steroid receptor coactivator 1 (SRC1) deficiency, SH2B1 deficiency, MC4 receptor deficiency, and obesity associated with Smith-Magenis syndrome, POMC epigenetic disorders, and other MC4R-related conditions. Rhythm Pharmaceuticals holds a collaborative research agreement with the Clinical Registry Investigating Bardet-Biedl Syndrome. The firm, headquartered in Boston, Massachusetts, was established in 2008 and changed its name from Rhythm Metabolic, Inc. to Rhythm Pharmaceuticals, Inc. in October 2015.
Sector: Pharmaceutical Preparations
Industry: Biotechnology
Rhythm Pharmaceuticals, Inc.
NASDAQ:RYTMHealthcare · Biotechnology
-0.54%$92.57
AH$92.57+0.00%vs close
Mkt Cap$6.37B
Float64.39M
O/S68.85M
Vol
$ Vol
RVOL
Inst Own-
SI17.1%
Earnings
Dilution
Financials Summary
Revenue$189.76M
Net Income-$196.54M
Total Assets$480.2M
Free Cash Flow-$116.63M
Debt & Equity
Debt 1%
Equity 67%
Preferred 32%
Total Debt$3.99M
Total Equity$270.03M
Preferred Stock$130.96M
Shares Outstanding
Short Interest
Split History
No splits on record
Nothing in RYTM's public trading history: no forward or reverse split has affected the share count.
Balance Sheet Details
Assets$480.2M
Liabilities$210.17M
Accounts Receivable$26.08M
Accounts Payable$13.95M
Inventory$25.75M
PP&E (Net)$4.15M
Goodwill$0
Intangible Assets$5.32M
Income Statement
| Period | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 | FY 2015 | FY 2014 | FY 2013 | FY 2012 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Currency | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD |
| Period Ending | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | 2020-12-31 | 2019-12-31 | 2018-12-31 | 2017-12-31 | 2016-12-31 | 2015-12-31 | 2014-12-31 | 2013-12-31 | 2012-12-31 |
| Revenue | $189.76M | $130.13M | $77.43M | $23.64M | $3.15M | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| YoY Growth | 45.8% | 68.1% | 227.6% | 649.5% | - | - | - | - | - | - | - | - | - | - |
| Cost of Revenue | $19.49M | $13.37M | $9.3M | $2.13M | $599K | $690K | $834K | $442K | $223K | $144K | $0 | $0 | $0 | $0 |
| Gross Profit | $170.26M | $116.76M | $68.13M | $21.5M | $2.56M | -$690K | -$834K | -$442K | -$223K | -$144K | $0 | $0 | $0 | $0 |
| Gross Margin | 89.7% | 89.7% | 88.0% | 91.0% | 81.0% | - | - | - | - | - | - | - | - | - |
| Research and Development | $167.34M | $237.96M | $134.95M | $108.63M | $104.13M | $90.45M | $109.45M | $50.34M | $22.89M | $19.59M | $7.15M | $5.28M | $18.02M | $15.68M |
| Selling, General, and Administrative | $194.94M | $144.3M | $117.53M | $92.03M | $68.49M | $46.13M | $36.55M | $28.08M | $9.52M | $6.31M | $3.42M | $1.21M | $3.43M | $2.46M |
| Other | $0 | $0 | $0 | $0 | $0 | -$690K | -$834K | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Total Operating Expenses | $362.28M | $382.26M | $252.48M | $200.66M | $172.61M | $135.88M | $145.17M | $78.42M | $32.41M | $25.91M | $10.57M | $6.49M | $21.45M | $18.14M |
| Operating Income (EBIT) | -$192.02M | -$265.5M | -$184.36M | -$179.16M | -$170.06M | -$136.57M | -$146M | -$78.42M | -$32.41M | -$25.91M | -$10.57M | -$6.49M | -$21.45M | -$18.14M |
| Operating Margin | -101.2% | -204.0% | -238.1% | -757.9% | -5391.9% | - | - | - | - | - | - | - | - | - |
| Interest Expense | $20.58M | $20.6M | $13.89M | $5.2M | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Interest Income | $15.29M | $14.71M | $13.95M | $4.03M | $447K | $2.58M | $5.27M | $4.35M | $566K | $33K | $0 | $0 | $0 | $0 |
| Other Income (Expense) | -$4.03M | $5.25M | $243K | -$1.96M | $100.45M | $2.58M | $5.27M | $4.35M | -$1.3M | $33K | -$500K | $0 | $17K | $8K |
| Income Before Tax (EBT) | -$196.04M | -$260.26M | -$184.11M | -$181.12M | -$69.61M | -$134M | -$140.73M | -$74.06M | -$33.71M | -$25.87M | -$11.07M | -$6.49M | -$21.43M | -$18.13M |
| Income Tax Expense | $497K | $346K | $564K | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Net Income | -$196.54M | -$260.6M | -$184.68M | -$181.12M | -$69.61M | -$130.73M | -$134.62M | -$74.06M | -$33.71M | -$25.87M | -$11.07M | -$6.49M | -$21.43M | -$18.13M |
| Net Income Margin | -103.6% | -200.3% | -238.5% | -766.2% | -2207.1% | - | - | - | - | - | - | - | - | - |
| Supplementary Data | ||||||||||||||
| EPS | -3.11 | -4.34 | -3.20 | -3.51 | -1.37 | -2.96 | -3.70 | -2.39 | -1.26 | -1.55 | -1.09 | -0.64 | -0.43 | -0.36 |
| Diluted EPS | -3.11 | -4.34 | -3.20 | -3.51 | -1.37 | -2.96 | -3.70 | -2.39 | -1.26 | -1.55 | -1.09 | -0.64 | -0.43 | -0.36 |
| Weighted Average OS | 64.98M | 60.99M | 57.67M | 52.12M | 49.60M | 44.13M | 36.42M | 31.00M | 26.73M | 16.73M | 10.20M | 10.20M | 50.27M | 50.27M |
| EBITDA | -$174.12M | -$238.09M | -$168.46M | -$174.25M | -$68.45M | -$135.88M | -$145.17M | -$77.97M | -$32.19M | -$25.76M | -$500K | $0 | -$21.41M | -$18.12M |
| EBITDA Margin | -91.8% | -183.0% | -217.6% | -737.1% | -2170.4% | - | - | - | - | - | - | - | - | - |
Balance Sheet
| Period | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 | FY 2015 | FY 2014 | FY 2013 | FY 2012 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Currency | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD |
| Period Ending | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | 2020-12-31 | 2019-12-31 | 2018-12-31 | 2017-12-31 | 2016-12-31 | 2015-12-31 | 2014-12-31 | 2013-12-31 | 2012-12-31 |
| Assets | ||||||||||||||
| Current Assets | ||||||||||||||
| Cash and Cash Equivalents | $54.3M | $89.14M | $60.08M | $127.68M | $59.25M | $100.85M | $62.29M | $49.54M | $34.24M | $6.54M | $34.87M | $152K | $7.36M | $11.77M |
| Short-Term Investments | $334.65M | $231.43M | $215.76M | $205.61M | $235.61M | $71.94M | $230.16M | $202.52M | $113.85M | $4M | $0 | $0 | $10.4M | $5.27M |
| Cash and Short-Term Investments | $388.95M | $320.56M | $275.85M | $333.29M | $294.86M | $172.79M | $292.46M | $252.06M | $148.08M | $10.54M | $34.87M | $152K | $17.76M | $17.04M |
| Accounts Receivable | $26.08M | $18.51M | $14.87M | $6.22M | $1.02M | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Inventory | $25.75M | $18.74M | $8.62M | $2.92M | $111K | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Other Current Assets | $9.97M | $8.8M | $6.67M | $7.42M | $3.99M | $3.05M | $3.51M | $1.34M | $1.06M | $216K | $623K | $42K | $0 | $0 |
| Total Current Assets | $466.92M | $374.2M | $308.27M | $354.24M | $308.39M | $181.67M | $302.4M | $258.69M | $150.67M | $11.18M | $35.49M | $194K | $18.14M | $18.86M |
| Long-Term Assets | ||||||||||||||
| Property, Plant & Equipment Net | $4.15M | $4.11M | $2.12M | $3.38M | $4.33M | $5M | $5.72M | $1.12M | $840K | $930K | $17K | $0 | $24K | $44K |
| Goodwill | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Intangible Assets | $5.32M | $6.17M | $7.03M | $7.88M | $4.66M | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Long-Term Investments | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Deferred Tax Assets | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Other Long-Term Assets | $3.81M | $7.79M | $15.33M | $16.98M | $12.14M | $403K | $403K | $401K | $225K | $234K | $1.77M | $0 | $23K | $23K |
| Total Long-Term Assets | $13.28M | $18.07M | $24.48M | $28.25M | $21.14M | $5.41M | $6.12M | $1.52M | $1.06M | $1.16M | $1.78M | $0 | $47K | $67K |
| Other Assets | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Total Assets | $480.2M | $392.27M | $332.75M | $382.48M | $329.52M | $187.07M | $308.52M | $260.21M | $151.74M | $12.34M | $37.27M | $194K | $18.19M | $18.92M |
| Liabilities | ||||||||||||||
| Current Liabilities | ||||||||||||||
| Accounts Payable | $13.95M | $12.33M | $4.88M | $4.8M | $5.74M | $4.9M | $10.41M | $7.64M | $2.43M | $1.9M | $1.43M | $535K | $1.47M | $2.25M |
| Short-Term Debt | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Current Income Tax Payable | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Current Unearned Revenue | $194K | $1.29M | $1.29M | $1.43M | $7M | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Other Current Liabilities | $11.37M | $43.59M | $5.41M | $2.42M | $800K | $180K | $377K | $60K | $101K | $156K | $249K | $0 | $12K | $23K |
| Total Current Liabilities | $105.94M | $115.52M | $55.2M | $39.81M | $43.43M | $17.99M | $24.42M | $13.58M | $6.72M | $4.73M | $5.27M | $552K | $3.06M | $2.5M |
| Long-Term Liabilities | ||||||||||||||
| Long-Term Debt | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Long-Term Unearned Revenue | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Long-Term Deferred Tax Liabilities | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Other Long-Term Liabilities | $100.89M | $108.27M | $107.29M | $77.15M | $0 | $0 | $0 | $372K | $228K | $311K | $0 | $0 | $72.59M | $52.7M |
| Total Long-Term Liabilities | $104.23M | $112.21M | $107.78M | $78.41M | $1.95M | $2.55M | $3.09M | $372K | $228K | $311K | $0 | $0 | $72.59M | $52.7M |
| Other Liabilities | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Total Liabilities | $210.17M | $227.72M | $162.99M | $118.22M | $45.37M | $20.55M | $27.5M | $13.95M | $6.95M | $5.04M | $5.27M | $552K | $75.65M | $55.21M |
| Stockholders' Equity | ||||||||||||||
| Preferred Stock | $130.96M | $142.82M | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $40M | $40M | $0 | $0 | $0 |
| Common Stock | $67K | $61K | $59K | $56K | $50K | $44K | $44K | $34K | $27K | $10K | $93K | $93K | $53K | $3K |
| Retained Earnings | -$1.35B | -$1.16B | -$894.74M | -$710.06M | -$528.94M | -$459.33M | -$325.33M | -$184.6M | -$110.25M | -$76.54M | -$50.67M | -$39.6M | -$58.44M | -$37.01M |
| Comprehensive Income & Other | -$796K | -$39K | $134K | -$92K | -$1K | $49K | $0 | $0 | $0 | -$144K | $0 | $0 | $8K | -$26K |
| Other Stockholders' Equity | $1.62B | $1.32B | $1.06B | $974.26M | $813.04M | $625.81M | $606.31M | $430.82M | $255.01M | $83.83M | $82.58M | $39.15M | $925K | $720K |
| Total Equity | $270.03M | $164.55M | $169.76M | $264.26M | $284.15M | $166.53M | $281.02M | $246.26M | $144.79M | $7.3M | $32M | -$358K | -$57.46M | -$36.28M |
| Minority Interest | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Total Liabilities and Equity | $480.2M | $392.27M | $332.75M | $382.48M | $329.52M | $187.07M | $308.52M | $260.21M | $151.74M | $12.34M | $37.27M | $194K | $18.19M | $18.92M |
| Supplementary Data | ||||||||||||||
| Total Debt | $3.99M | $3.94M | $1.26M | $1.94M | $2.55M | $3.09M | $3.56M | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Net Debt | -$50.31M | -$85.2M | -$58.82M | -$125.73M | -$56.7M | -$97.77M | -$58.74M | -$49.54M | -$34.24M | -$6.54M | -$34.87M | -$152K | -$7.36M | -$11.77M |
Cash Flow Statement
| Period | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 | FY 2015 | FY 2014 | FY 2013 | FY 2012 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Currency | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD |
| Period Ending | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | 2020-12-31 | 2019-12-31 | 2018-12-31 | 2017-12-31 | 2016-12-31 | 2015-12-31 | 2014-12-31 | 2013-12-31 | 2012-12-31 |
| Operating Activities | ||||||||||||||
| Net Income | -$196.54M | -$260.6M | -$184.68M | -$181.12M | -$69.61M | -$134M | -$140.73M | -$74.06M | -$33.71M | -$25.87M | -$11.07M | -$6.49M | -$21.43M | -$18.13M |
| Depreciation & Amortization | $1.34M | $1.56M | $1.76M | $1.67M | $1.16M | $690K | $834K | $442K | $223K | $144K | $10.57M | $6.49M | $20K | $17K |
| Deferred Income Tax | $0 | $0 | $0 | $0 | -$100M | $0 | $0 | $0 | $1.86M | $0 | $0 | $0 | $0 | $0 |
| Stock-Based Compensation | $66.82M | $39.68M | $32.55M | $19.83M | $20.8M | $17.45M | $11.88M | $6.39M | $2.28M | $1.17M | $298K | $66K | $127K | $0 |
| Changes in Working Capital: | ||||||||||||||
| Accounts Receivable | -$7.57M | -$3.65M | -$8.64M | -$5.2M | -$1.25M | $0 | $0 | $0 | $0 | $0 | -$60K | $0 | $0 | $0 |
| Inventory | -$7.47M | -$10.12M | -$5.71M | -$2.81M | -$11K | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Accounts Payable | $21.89M | $21.92M | $14.77M | $1.54M | $18.31M | -$6.45M | $10.51M | $6.95M | $1.95M | $467K | $3.84M | $0 | -$780K | $1.58M |
| Other Working Capital | -$7.82M | $2.42M | $4.38M | -$13.26M | -$15.15M | $551K | -$5.44M | -$6.29M | -$1.99M | $863K | -$1.46M | -$801K | $2.78M | -$1.38M |
| Total Working Capital Change | -$968K | $10.57M | $4.81M | -$19.72M | $1.9M | -$5.89M | $5.07M | $667K | -$39K | $1.33M | $2.38M | -$801K | $2M | $201K |
| Other Non-Cash Items | $13.68M | $94.9M | $9.4M | $5.91M | -$250K | -$234K | $203K | $4.51M | -$76K | $11K | -$9.15M | -$6.77M | $255K | $82K |
| Net Cash from Operating | -$115.67M | -$113.88M | -$136.16M | -$173.43M | -$146M | -$121.98M | -$122.75M | -$62.06M | -$29.46M | -$23.22M | -$6.98M | -$7.51M | -$19.16M | -$17.83M |
| Investing Activities | ||||||||||||||
| Capital Expenditures | -$953K | $0 | -$47K | -$4.28M | -$5.43M | -$214K | -$3.38M | -$722K | -$133K | -$1.06M | -$17K | $0 | $0 | $0 |
| Acquisitions | $0 | $0 | $0 | $4M | $100M | $0 | $24.59M | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Purchases of Investments | -$348.67M | -$268.31M | -$354.92M | -$251.94M | -$524.97M | -$86.87M | -$295.82M | -$248.59M | -$126.92M | -$15.22M | $0 | $0 | -$28.74M | -$8.8M |
| Sales of Investments | $252.47M | $260.64M | $354.97M | $284.25M | $361.25M | $245.61M | $271.24M | $162.17M | $17.01M | $11.17M | $0 | $0 | $23.61M | $3.53M |
| Other Investing Activities | -$40M | -$40.5M | -$5.67M | -$4M | $7M | $0 | -$24.59M | -$86.43M | -$109.91M | -$4.05M | $0 | $0 | $0 | $0 |
| Net Cash from Investing | -$137.15M | -$48.17M | -$5.67M | $28.03M | -$62.16M | $158.53M | -$27.97M | -$87.15M | -$110.04M | -$5.11M | -$17K | $0 | -$5.13M | -$5.27M |
| Financing Activities | ||||||||||||||
| Debt Repaid | - | $12.9M | - | - | - | - | - | - | - | - | - | - | - | - |
| Common Stock Issuance | $237.88M | $195.24M | $48.88M | $131.11M | $161.73M | $0 | $161.35M | $162.88M | $125.66M | $0 | $39.62M | $0 | $0 | $43K |
| Common Stock Repurchases | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Dividends Paid | $0 | -$3.97M | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Other Financing Activities | -$19.92M | $12.87M | $25.49M | $82.72M | $4.75M | $2.01M | $2.12M | $1.81M | $700K | $0 | $2.09M | $7.42M | $0 | $0 |
| Net Cash from Financing | $217.96M | $191.24M | $74.37M | $213.83M | $166.48M | $2.01M | $163.47M | $164.69M | $167.2M | $0 | $41.71M | $7.42M | $19.88M | $22.44M |
| Forex Effect | $87K | $2K | -$142K | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Net Change in Cash | -$34.78M | $29.19M | -$67.6M | $68.43M | -$41.68M | $38.56M | $12.75M | $15.48M | $27.7M | -$28.33M | $34.72M | -$89K | -$4.4M | -$660K |
| Supplementary Data | ||||||||||||||
| Operating Cash Flow | -$115.67M | -$113.88M | -$136.16M | -$173.43M | -$146M | -$121.98M | -$122.75M | -$62.06M | -$29.46M | -$23.22M | -$6.98M | -$7.51M | -$19.16M | -$17.83M |
| Capital Expenditure | -$953K | $0 | -$47K | -$4.28M | -$5.43M | -$214K | -$3.38M | -$722K | -$133K | -$1.06M | -$17K | $0 | $0 | $0 |
| Free Cash Flow | -$116.63M | -$113.88M | -$136.2M | -$177.71M | -$151.44M | -$122.19M | -$126.14M | -$62.78M | -$29.59M | -$24.28M | -$6.99M | -$7.51M | -$19.16M | -$17.83M |
| Cash at Beginning | $89.6M | $60.41M | $128M | $59.58M | $101.26M | $62.7M | $49.94M | $34.46M | $6.54M | $34.87M | $152K | $241K | $11.77M | $12.43M |
| Cash at End | $54.82M | $89.6M | $60.41M | $128M | $59.58M | $101.26M | $62.7M | $49.94M | $34.24M | $6.54M | $34.87M | $152K | $7.36M | $11.77M |