Sol-Gel Technologies Ltd. (SLGL)
Sol-Gel Technologies Ltd., a pharmaceutical firm currently in its clinical development phase, specializes in the creation and market introduction of skin-applied medications. These products leverage the company's distinctive microencapsulation technology, with their primary development and commercialization activities centered in Israel. Sol-Gel's pipeline features several key candidates. Twyneo, an innovative, non-antibiotic topical cream designed for once-daily application, has successfully concluded Phase III trials for treating acne vulgaris. Similarly, Epsolay, another topical cream administered once a day, has also completed its Phase III studies, targeting papulopustular rosacea. Advancing through Phase I clinical trials is SGT-210, intended for palmoplantar keratoderma. Furthermore, the company is investigating Erlotinib, Tapinarof, and Roflumilast as potential treatments for psoriasis and various other medical conditions. Beyond its proprietary offerings, the company also engages in creating generic versions of topical dermatological medications. Sol-Gel Technologies maintains a strategic partnership with Perrigo. Established in 1997, the company maintains its headquarters in Ness Ziona, Israel.
Sector: Pharmaceutical Preparations
Industry: Biotechnology
Sol-Gel Technologies Ltd.
Trials need funding. See this company's dilution risk and cash position.
- Phase 3Completed
A Study of S5G4T-1 in the Treatment of Papulopustular Rosacea
S5G4T-1, S5G4T-2
Papulopustular Rosacea
NCT03448939Enrollment361StartJun 2018Primary CompletionMay 2019CompletionMay 2019 - Phase 3Completed
A Study of S5G4T-1 in the Treatment of Papularpustular Rosacea
S5G4T-1, S5G4T-2
Papulopustular Rosacea
NCT03564119Enrollment372StartJun 2018Primary CompletionJun 2019CompletionJun 2019 - Phase 3Terminated
A Long-Term Safety Study of S5G4T-1 in the Treatment of Papulopustular Rosacea
S5G4T-1
Papulopustular Rosacea
NCT03564145Enrollment547StartSep 2018Primary CompletionNov 2019CompletionNov 2019 - Phase 3Completed
Study of Patidegib Topical Gel, 2%, for the Reduction of Disease Burden of Persistently Developing Basal Cell Carcinomas (BCCs) in Subjects With Basal Cell Nevus Syndrome (Gorlin Syndrome)
Patidegib Topical Gel, 2%, Patidegib Topical Gel, Vehicle
Basal Cell Nevus Syndrome
NCT03703310Enrollment174StartFeb 2019Primary CompletionDec 2020CompletionDec 2020 - Phase 3Completed
Bioequivalence Study to Compare Sol-Gel Technologies' 5-FU Cream With Efudex® (5-FU) Cream
5-FU Cream, Efudex®
Actinic Keratosis (AK)
NCT03727074Enrollment462StartDec 2018Primary CompletionDec 2019CompletionDec 2019 - Phase 3Completed
A Study of S6G5T-3 in the Treatment of Acne Vulgaris
S6G5T-3, S6G5T-8
Acne Vulgaris
NCT03761784Enrollment424StartDec 2018Primary CompletionDec 2019CompletionDec 2019 - Phase 3Completed
A Study of S6G5T3 in the Treatment of Acne Vulgaris
S6G5T-3, S6G5T-8
Acne Vulgaris
NCT03761810Enrollment434StartDec 2018Primary CompletionOct 2019CompletionOct 2019 - Phase 3Terminated
Extension Study of Patidegib Topical Gel, 2% in Subjects With Gorlin Syndrome (Basal Cell Nevus Syndrome)
Patidegib Topical Gel, 2%
Basal Cell Nevus Syndrome
NCT04308395Enrollment108StartJun 2020Primary CompletionJul 2021CompletionJul 2021 - Phase 3Completed
Efficacy and Safety of Patidegib Gel 2% for Preventing Basal Cell Carcinomas on the Face of Adults With Gorlin Syndrome
Patidegib Topical Gel, Patidegib Topical Gel with no active patidegib
Gorlin Syndrome
NCT06050122Enrollment113StartMar 2024Primary CompletionAug 2026CompletionSep 2026 - Phase 2Completed
A Study of DER 45-EV Gel to Treat Rosacea
DER 45 EV, Vehicle
Rosacea
NCT00940992Enrollment92StartJan 2012Primary CompletionSep 2012CompletionJan 2013 - Phase 2Completed
Efficacy, Safety, and Tolerability of S6G5T-1 and S6G5T-3 for the Treatment of Acne Vulgaris
S6G5T-3, S6G5T-1
Acne Vulgaris
NCT02661958Enrollment726StartMay 2016Primary CompletionOct 2017CompletionOct 2017 - Phase 2Terminated
Efficacy and Safety of Product S2G6T-1in Patients With Symptomatic Inflammatory Interdigital Tinea Pedis
S2G6T-1, S2G6T-2
Tinea Pedis
NCT02842021Enrollment283StartSep 2016Primary CompletionOct 2017CompletionOct 2017 - Phase 2Terminated
A Study of Patidegib Topical Gel, 2%, for the Reduction of Disease Burden of Persistently Developing Basal Cell Carcinomas in Patients With Non-Gorlin High Frequency BCC
Patidegib Topical Gel, 2%, Patidegib Topical Gel, Vehicle
Recurrent Basal Cell Carcinoma
NCT04155190Enrollment50StartDec 2019Primary CompletionApr 2021CompletionApr 2021 - Phase 1Completed
MUSE Study to Evaluate the Pharmacokinetics, Safety and Tolerability of S6G5T-3
S6G5T-3, Retin-A® 0.1% Cream
Acne Vulgaris
NCT04059523Enrollment62StartJun 2019Primary CompletionFeb 2020CompletionFeb 2020 - Phase 1Completed
Evaluation of Topical Encapsulated Benzoyl Peroxide on the Skin Microbiome and Skin Biophysical Properties
Encapsulated Benzoyl Peroxide Cream
Papulopustular Rosacea
NCT05675501Enrollment31StartJun 2020Primary CompletionJul 2021CompletionJul 2021
| Drug / Therapy | Link | ||
|---|---|---|---|
| Phase 3 | Completed | S5G4T-1, S5G4T-2 | NCT03448939 |
| Phase 3 | Completed | S5G4T-1, S5G4T-2 | NCT03564119 |
| Phase 3 | Terminated | S5G4T-1 | NCT03564145 |
| Phase 3 | Completed | Patidegib Topical Gel, 2%, Patidegib Topical Gel, Vehicle | NCT03703310 |
| Phase 3 | Completed | 5-FU Cream, Efudex® | NCT03727074 |
| Phase 3 | Completed | S6G5T-3, S6G5T-8 | NCT03761784 |
| Phase 3 | Completed | S6G5T-3, S6G5T-8 | NCT03761810 |
| Phase 3 | Terminated | Patidegib Topical Gel, 2% | NCT04308395 |
| Phase 3 | Completed | Patidegib Topical Gel, Patidegib Topical Gel with no active patidegib | NCT06050122 |
| Phase 2 | Completed | DER 45 EV, Vehicle | NCT00940992 |
| Phase 2 | Completed | S6G5T-3, S6G5T-1 | NCT02661958 |
| Phase 2 | Terminated | S2G6T-1, S2G6T-2 | NCT02842021 |
| Phase 2 | Terminated | Patidegib Topical Gel, 2%, Patidegib Topical Gel, Vehicle | NCT04155190 |
| Phase 1 | Completed | S6G5T-3, Retin-A® 0.1% Cream | NCT04059523 |
| Phase 1 | Completed | Encapsulated Benzoyl Peroxide Cream | NCT05675501 |