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Syndax Pharmaceuticals Inc (SNDX)

Syndax Pharmaceuticals, Inc. operates as a clinical-stage biopharmaceutical firm focused on developing innovative therapies for cancer. Among its leading investigational products are SNDX-5613, currently undergoing Phase 1/2 clinical assessment, which targets the Menin-mixed lineage leukemia 1 protein interaction for treating MLL-rearranged (MLLr) and nucleophosmin 1 mutant acute myeloid leukemia (NPM1c AML). Another significant candidate is SNDX-6352, or axatilimab, a monoclonal antibody designed to block the colony stimulating factor 1 (CSF-1) receptor, intended for patients suffering from chronic graft versus host disease (cGVHD). The company is additionally progressing Entinostat. Syndax has also established strategic collaborations, including a research and development agreement with the National Cancer Institute, a clinical trial agreement with the Eastern Cooperative Oncology Group, and a license agreement with Kyowa Hakko Kirin Co., Ltd. Founded in 2005, Syndax Pharmaceuticals, Inc. maintains its corporate headquarters in Waltham, Massachusetts.

Sector: Pharmaceutical Preparations

Industry: Biotechnology

Syndax Pharmaceuticals, Inc. logo

Syndax Pharmaceuticals, Inc.

NASDAQ:SNDXHealthcare
-3.53%$13.65
AH$13.65+0.00%vs close
Mkt Cap$1.22B
Float84.21M
O/S89.3M
Vol
$ Vol
RVOL
Inst Own-
SI21.4%
Earnings
Dilution
Financials Summary
Revenue$172.35M
Net Income-$285.42M
Total Assets$529.71M
Free Cash Flow-$323.17M
Debt & Equity
Debt 84%
Equity 16%
Total Debt$346.48M
Total Equity$64.63M
Shares Outstanding
Short Interest
Split History

No splits on record

Nothing in SNDX's public trading history: no forward or reverse split has affected the share count.

Balance Sheet Details
Assets$529.71M
Liabilities$465.08M
Accounts Receivable$70.29M
Accounts Payable$16.58M
Inventory$32.75M
PP&E (Net)$1.52M
Goodwill$0
Intangible Assets$0
Income Statement
PeriodFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016FY 2015FY 2014FY 2013FY 2012FY 2011
CurrencyUSDUSDUSDUSDUSDUSDUSDUSDUSDUSDUSDUSDUSDUSDUSD
Period Ending2025-12-312024-12-312023-12-312022-12-312021-12-312020-12-312019-12-312018-12-312017-12-312016-12-312015-12-312014-12-312013-12-312012-12-312011-12-31
Revenue$172.35M$23.68M$0$0$139.71M$1.52M$1.52M$1.52M$2.11M$1.22M$627K$0$0$0$0
YoY Growth627.8%---9109.6%0.0%0.0%-28.0%72.8%94.6%-----
Cost of Revenue$6.97M$826K$0$0$0$0$0$0$0$0$0$0$0$0$51K
Gross Profit$165.38M$22.85M$0$0$139.71M$1.52M$1.52M$1.52M$2.11M$1.22M$627K$0$0$0-$51K
Gross Margin96.0%96.5%--100.0%100.0%100.0%100.0%100.0%100.0%100.0%----
Research and Development$258.78M$241.65M$163.03M$118.5M$88.25M$50.44M$42.99M$60.11M$48.2M$31.66M$9.55M$10.18M$3.21M$5.24M$6.09M
Selling, General, and Administrative$179.68M$120.88M$66.92M$33.26M$25.24M$22.5M$16.06M$17.29M$15.86M$13.32M$11.59M$11.16M$5.36M$3.49M$3.48M
Other$0$0$0$0$0$0$0$0$0$0-$37K$4K$0-$1K$0
Total Operating Expenses$438.47M$362.53M$229.95M$151.76M$113.49M$72.94M$59.06M$77.39M$64.06M$44.99M$21.14M$21.33M$8.57M$8.73M$9.57M
Operating Income (EBIT)-$273.08M-$339.67M-$229.95M-$151.76M$26.22M-$71.42M-$57.54M-$75.88M-$61.95M-$43.77M-$20.51M-$21.33M-$8.57M-$8.73M-$9.62M
Operating Margin-158.4%-1434.4%--18.8%-4708.2%-3792.9%-5001.7%-2939.0%-3587.4%-3271.6%----
Interest Expense$33.78M$4.93M$208K$3.14M$1.9M$2.36M$0$1.94M$1.42M$956K$1.57M$0$0$0$1.99M
Interest Income$22.73M$26.09M$21.16M$5.87M$403K$841K$1.57M$0$0$0$161K$0$0$0$0
Other Income (Expense)-$12.34M$20.91M$20.59M$2.42M-$1.29M-$1.74M$1.49M$1.92M$1.15M-$706K-$3.61M$1.5M-$5.6M-$1.23M-$3.47M
Income Before Tax (EBT)-$285.42M-$318.76M-$209.36M-$149.34M$24.93M-$73.16M-$56.05M-$73.96M-$60.8M-$44.47M-$24.12M-$19.83M-$14.17M-$9.96M-$13.09M
Income Tax Expense$0$0$0$0$0$0$0$0-$76K-$89K$0$0$0$0$0
Net Income-$285.42M-$318.76M-$209.36M-$149.34M$24.93M-$73.07M-$55.95M-$73.96M-$60.8M-$44.47M-$24.12M-$19.83M-$14.17M-$9.96M-$13.09M
Net Income Margin-165.6%-1346.1%--17.8%-4816.7%-3688.5%-4875.5%-2884.3%-3645.2%-3846.7%----
Supplementary Data
EPS-3.29-3.73-2.98-2.460.48-1.77-1.84-2.92-2.90-3.04-4.31-2.07-1.77-0.14-0.00
Diluted EPS-3.29-3.73-2.98-2.460.48-1.77-1.84-2.92-2.90-3.04-4.31-2.07-1.77-0.14-0.00
Weighted Average OS86.63M85.62M70.37M60.76M52.06M41.31M30.49M25.37M21.00M14.62M5.59M9.60M8.01M70.28M619.96B
EBITDA-$251.63M-$313.82M-$209.14M-$146.17M$26.87M-$70.71M-$55.95M-$73.88M-$61.88M-$43.68M-$20.49M-$21.32M-$8.56M-$5.26M-$11.05M
EBITDA Margin-146.0%-1325.3%--19.2%-4661.3%-3688.5%-4870.3%-2935.4%-3580.1%-3268.3%----
Balance Sheet
PeriodFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016FY 2015FY 2014FY 2013FY 2012FY 2011
CurrencyUSDUSDUSDUSDUSDUSDUSDUSDUSDUSDUSDUSDUSDUSDUSD
Period Ending2025-12-312024-12-312023-12-312022-12-312021-12-312020-12-312019-12-312018-12-312017-12-312016-12-312015-12-312014-12-312013-12-312012-12-312011-12-31
Assets
Current Assets
Cash and Cash Equivalents$134.93M$154.08M$295.39M$74.36M$221.97M$115.24M$24.61M$33.77M$35.17M$23.84M$23.18M$10.01M$10.1M$537K$3.7M
Short-Term Investments$278.76M$428.83M$282.19M$410.04M$224.87M$177.82M$35.17M$47.14M$94.81M$81.49M$64.11M$2.2M$4.16M$91K$613K
Cash and Short-Term Investments$413.69M$582.91M$577.58M$484.4M$446.83M$293.06M$59.77M$80.91M$133.22M$105.33M$87.29M$12.21M$14.26M$628K$4.31M
Accounts Receivable$70.29M$13.87M$1.23M$4.06M$429K$175K$116K$253K$377K$306K$258K$35K$0$0$0
Inventory$32.75M$366K$0$0$0$0$0$1.05M-$1.44M$2.41M$264K$51K$0$0$0
Other Current Assets$1.22M-$2.02M$63K$117K$265K$456K$2.06M$1.79M$1.29M$615K$996K$150K$50K$83K$77K
Total Current Assets$528.08M$603.06M$580.88M$489.79M$448.4M$298.86M$62.33M$83.35M$133.44M$108.51M$88.01M$12.44M$14.54M$735K$4.39M
Long-Term Assets
Property, Plant & Equipment Net$1.52M$2.02M$1.5M$1.06M$1.26M$482K$997K$373K$267K$260K$88K$33K$40K$20K$50K
Goodwill$0$0$0$0$0$0$0$0$0$0$0$0$0$0$0
Intangible Assets$0$0$0$0$0$0$0$0$0$0$0$0$0$0$0
Long-Term Investments$0$119.52M$29.83M$5.47M$0$0$115K$0$3.25M$0$0$0$0$0$0
Deferred Tax Assets$0$0$0$0$0$0$0$0$0$0$0$0$0$0$0
Other Long-Term Assets$102K$217K$680K$922K$0$1.27M$82K$219K$231K$243K$1.81M$339K$2.48M$755K$345K
Total Long-Term Assets$1.63M$121.76M$32M$7.45M$1.26M$1.75M$1.19M$592K$3.74M$503K$1.9M$372K$2.52M$775K$395K
Other Assets$0$0$0$0$0$0$0$0$0$0$0$0$0$0$0
Total Assets$529.71M$724.82M$612.88M$497.24M$449.66M$300.61M$63.52M$83.94M$137.19M$109.01M$89.9M$12.82M$17.06M$1.51M$4.79M
Liabilities
Current Liabilities
Accounts Payable$16.58M$11.63M$9.96M$4.35M$5.67M$3.51M$6.18M$1.44M$2.23M$2.38M$1.45M$354K$1.08M$776K$810K
Short-Term Debt$0$12.12M$0$0$0$2.29M$0$0$0$0$0$6.45M$0$21.34M$10.68M
Current Income Tax Payable$0$0$0$0$0$0$0$0$0$0$0$0$0$0$0
Current Unearned Revenue$0$0$0$0$0$1.52M$1.52M$1.52M$1.57M$1.22M$1.22M$3.38M$0$2.41M$0
Other Current Liabilities$103.06M$15.75M$35.92M$6.55M$6.23M$3.74M$7.39M$10.35M$9.6M$5.13M$916K$1.94M$0$660K$1.92M
Total Current Liabilities$120.12M$103.55M$58.1M$29.07M$20.68M$18.87M$18.37M$16.11M$15.8M$10.37M$4.85M$10.35M$2.73M$25.1M$13.41M
Long-Term Liabilities
Long-Term Debt$344.96M$331.56M$0$0$19.89M$17.83M$0$0$0$0$0$7.43M$0$0$8.66M
Long-Term Unearned Revenue$0$0$0$0$0$11.62M$13.13M$14.65M$16.76M$14.22M$15.44M$0$0$0$0
Long-Term Deferred Tax Liabilities$0$0$0$0$0$0$0$0$0$0$0$0$0$0$0
Other Long-Term Liabilities-$1.05M$0$0$0$0$1K$5K$136K$310K$288K$2.92M$751K$2.48M$5.69M$1.77M
Total Long-Term Liabilities$344.96M$333.14M$588K$722K$20.61M$29.55M$13.56M$14.79M$17.07M$14.51M$18.36M$8.19M$2.48M$5.69M$10.44M
Other Liabilities$0$0$0$0$0$0$0$0$0$0$0$0$0$0$0
Total Liabilities$465.08M$436.69M$58.68M$29.79M$41.29M$48.42M$31.93M$30.89M$32.87M$24.87M$23.2M$18.53M$5.21M$30.8M$23.84M
Stockholders' Equity
Preferred Stock$0$0$0$0$0$0$0$0$0$0$326.34M$154.08M$147.56M$49M$49M
Common Stock$9K$9K$8K$7K$6K$5K$3K$2K$2K$2K$1K$1K$1K$0$0
Retained Earnings-$1.51B-$1.22B-$902.4M-$693.04M-$543.7M-$568.63M-$495.47M-$439.42M-$366.11M-$305.29M-$259.68M-$159.8M-$135.71M-$79.05M-$68.9M
Comprehensive Income & Other$452K$163K$218K-$806K$45K-$4K$0-$25K-$143K$56K$28K-$185K-$170K-$238K$0
Other Stockholders' Equity$1.57B$1.51B$1.46B$1.16B$952.06M$820.81M$527.07M$492.47M$470.43M$389.43M$326.37M$154.08M$147.56M$49.77M$49.84M
Total Equity$64.63M$288.12M$554.2M$467.45M$408.37M$252.19M$31.6M$53.05M$104.32M$84.14M$66.7M-$5.72M$11.85M-$29.29M-$19.05M
Minority Interest$0$0$0$0$0$0$0$0$0$0$0$0$0$0$0
Total Liabilities and Equity$529.71M$724.82M$612.88M$497.24M$449.66M$300.61M$63.52M$83.94M$137.19M$109.01M$89.9M$12.82M$17.06M$1.51M$4.79M
Supplementary Data
Total Debt$346.48M$345.74M$1.64M$1.16M$20.97M$20.54M$897K$0$0$0$0$13.88M$0$21.34M$19.34M
Net Debt$211.55M$191.66M-$293.76M-$73.19M-$201M-$94.71M-$23.71M-$33.77M-$35.17M-$23.84M-$23.18M$3.88M-$10.1M$20.81M$15.64M
Cash Flow Statement
PeriodFY 2025FY 2024FY 2023FY 2022FY 2021FY 2020FY 2019FY 2018FY 2017FY 2016FY 2015FY 2014FY 2013FY 2012FY 2011
CurrencyUSDUSDUSDUSDUSDUSDUSDUSDUSDUSDUSDUSDUSDUSDUSD
Period Ending2025-12-312024-12-312023-12-312022-12-312021-12-312020-12-312019-12-312018-12-312017-12-312016-12-312015-12-312014-12-312013-12-312012-12-312011-12-31
Operating Activities
Net Income-$285.42M-$318.76M-$209.36M-$149.34M$24.93M-$73.16M-$56.05M-$73.96M-$60.8M-$44.47M-$24.12M-$19.83M-$14.17M-$9.96M-$13.09M
Depreciation & Amortization$6K$8K$12K$33K$43K$89K$92K$78K$76K$89K$21K$15K$13K$34K$51K
Deferred Income Tax$0$0$0$0$255K$0-$780K-$558K$223K$1.58M$2.47M$2.57M$1.69M-$3.44M$0
Stock-Based Compensation$47.5M$43.03M$30.95M$16.02M$13.32M$9.06M$6M$6.2M$5.45M$4.71M$3.88M$2.26M$1.42M$139K$0
Changes in Working Capital:
  Accounts Receivable-$36.83M-$11.24M$10.71M-$3.47M$0$0$0$0$0$0$0$0$0$0$0
  Inventory-$32.09M-$366K$0$3.47M$0$0$0$0$0$0$0$0$0$0$0
  Accounts Payable$4.95M$1.67M$5.61M-$1.32M$2.16M-$2.67M$4.74M-$792K-$194K$923K$1.04M-$726K-$286K-$35K-$326K
  Other Working Capital-$15.35M$23.21M$15.54M$2.98M-$11.76M-$5.26M-$4.98M$490K$7.87M$1.99M$13.52M$1.28M$317K$858K$467K
Total Working Capital Change-$79.32M$13.27M$31.86M$1.66M-$9.6M-$7.93M-$241K-$302K$7.67M$2.92M$14.56M$551K$31K$823K$141K
Other Non-Cash Items-$5.75M-$12.45M-$14.06M-$2.04M$187K$686K$359K$11K$8K$25K$762K$40K$3.73M$3.13M$2.88M
Net Cash from Operating-$322.98M-$274.9M-$160.6M-$133.68M$29.13M-$71.26M-$50.61M-$68.53M-$47.37M-$35.16M-$2.43M-$14.39M-$7.29M-$9.28M-$10.02M
Investing Activities
Capital Expenditures-$187K$0$0-$225K-$129K$0$0-$187K-$84K-$261K-$49K-$4K-$38K-$11K-$8K
Acquisitions$0$0$0$225K$41K$0$0$0$0$0$0$0$0$0$0
Purchases of Investments-$195.81M-$557.05M-$354.61M-$495.35M-$294.72M-$278.94M-$104.02M-$78.84M-$152.26M-$158.32M-$102.01M-$3.39M-$4.02M$0-$500K
Sales of Investments$486.03M$337.28M$472.21M$308.93M$253.97M$136.41M$116.8M$130.43M$135.28M$140.3M$40.51M$5.29M$0$500K$2.75M
Other Investing Activities$0$0$0$225K-$41K$0$13K$52K$45K-$97K-$118K-$1K$33K$5K-$50K
Net Cash from Investing$290.04M-$219.78M$117.61M-$186.19M-$40.87M-$142.53M$12.78M$51.4M-$17.03M-$18.38M-$61.67M$1.89M-$4.03M$494K$2.19M
Financing Activities
Debt Repaid---$21M--$19.73M----$9M-$14M$3.68M-$6.31M-$8.63M
Common Stock Issuance$13.68M$9.71M$258.09M$181.39M$86.34M$278.06M$28.21M$15.5M$75.35M$52.15M$87.51M$6K$0$0$3K
Common Stock Repurchases$0$0$0$0$0$0$0$0$0$0$0$0$0$0$0
Dividends Paid$0$0$0$0$0$0$0$0$0-$2.6M$0$0$0$0$0
Other Financing Activities$0$343.65M$6.04M$11.86M$32.13M$6.63M$360K$232K$374K$4.65M-$1.06M-$1.59M$24.57M-$597K$0
Net Cash from Financing$13.68M$353.37M$264.13M$172.25M$118.46M$304.42M$28.57M$15.73M$75.72M$54.2M$77.27M$12.41M$20.89M$5.71M$8.63M
Forex Effect$0$0$0$0$0$0$0$0$0$0$0$0$0$0$0
Net Change in Cash-$19.27M-$141.31M$221.14M-$147.61M$106.72M$90.63M-$9.26M-$1.4M$11.32M$665K$13.17M-$95K$9.57M-$3.08M$0
Supplementary Data
Operating Cash Flow-$322.98M-$274.9M-$160.6M-$133.68M$29.13M-$71.26M-$50.61M-$68.53M-$47.37M-$35.16M-$2.43M-$14.39M-$7.29M-$9.28M-$10.02M
Capital Expenditure-$187K$0$0-$225K-$129K$0$0-$187K-$84K-$261K-$49K-$4K-$38K-$11K-$8K
Free Cash Flow-$323.17M-$274.9M-$160.6M-$133.9M$29M-$71.26M-$50.61M-$68.72M-$47.45M-$35.42M-$2.48M-$14.4M-$7.33M-$9.29M-$10.03M
Cash at Beginning$154.3M$295.61M$74.47M$222.08M$115.36M$24.72M$33.98M$35.39M$23.84M$23.18M$10.01M$10.1M$537K$3.62M$0
Cash at End$135.03M$154.3M$295.61M$74.47M$222.08M$115.36M$24.72M$33.98M$35.17M$23.84M$23.18M$10.01M$10.1M$537K$3.7M