Spyre Therapeutics, Inc. (SYRE)
Spyre Therapeutics, Inc. is a biotechnology firm operating at the preclinical stage, dedicated to creating innovative treatments for individuals afflicted with inflammatory bowel disease (IBD). Among its pipeline candidates is SPY001, a human monoclonal immunoglobulin G1 antibody specifically engineered to target and bind with the a4ß7 integrin. This particular therapy is under development for addressing both ulcerative colitis and Crohn's disease, two forms of IBD. Furthermore, Spyre Therapeutics is advancing SPY002, another human monoclonal antibody that aims to interact with tumor necrosis factor-like ligand 1A (TL1A). A synergistic approach is also being explored with SPY120, a compound that merges the anti-a4ß7 action of SPY001 with the anti-TL1A activity of SPY002. All these programs are currently undergoing preclinical evaluation. Beyond these, the company's early-stage portfolio encompasses several additional promising candidates: SPY003, an anti-IL-23 monoclonal antibody; SPY004, a monoclonal antibody with a novel mechanism of action; SPY130, which combines anti-a4ß7 and anti-IL-23 antibodies; and SPY230, a dual antibody therapy featuring anti-TL1A and anti-IL-23 components. Originally incorporated in 2013, the organization was previously known as Aeglea BioTherapeutics, Inc., before rebranding to Spyre Therapeutics, Inc. in November 2023. Its headquarters are located in Waltham, Massachusetts.
Sector: Pharmaceutical Preparations
Industry: Biotechnology
Spyre Therapeutics, Inc.
NASDAQ:SYREHealthcare · Biotechnology
-2.43%$96.56
AH$96.56+0.00%vs close
Mkt Cap$9.02B
Float80.15M
O/S93.45M
Vol
$ Vol
RVOL
Inst Own-
SI15.6%
Earnings
Dilution
Financials Summary
Revenue$0
Net Income-$155.2M
Total Assets$777.78M
Free Cash Flow-$169.25M
Debt & Equity
Equity 82%
Preferred 18%
Total Debt$0
Total Equity$715.24M
Preferred Stock$155.82M
Shares Outstanding
Short Interest
Split History1 split · 1 reverse
- 1:25Reverse splitSep 8, 202325 shares → 1
Balance Sheet Details
Assets$777.78M
Liabilities$62.55M
Accounts Receivable$0
Accounts Payable$8.9M
Inventory$0
PP&E (Net)$0
Goodwill$0
Intangible Assets$0
Income Statement
| Period | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 | FY 2015 | FY 2014 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Currency | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD |
| Period Ending | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | 2020-12-31 | 2019-12-31 | 2018-12-31 | 2017-12-31 | 2016-12-31 | 2015-12-31 | 2014-12-31 |
| Revenue | $0 | $0 | $886K | $2.33M | $18.74M | $0 | $0 | $3.89M | $5.21M | $4.63M | $6.08M | $0 |
| YoY Growth | - | - | -62.0% | -87.6% | - | - | - | -25.3% | 12.5% | -23.9% | - | - |
| Cost of Revenue | $171.65M | $0 | $0 | $0 | $0 | $1.62M | $901K | $0 | $0 | $0 | $0 | $19K |
| Gross Profit | -$171.65M | $0 | $886K | $2.33M | $18.74M | -$1.62M | -$901K | $0 | $0 | $0 | $0 | -$19K |
| Gross Margin | - | - | 100.0% | 100.0% | 100.0% | - | - | - | - | - | - | - |
| Research and Development | $171.65M | $162.79M | $89.5M | $58.58M | $57.07M | $59.64M | $64.6M | $36.72M | $22.82M | $18.14M | $11.45M | $6.83M |
| Selling, General, and Administrative | $47.91M | $45.78M | $39.95M | $28.53M | $27.32M | $20.22M | $14.83M | $12.63M | $10.07M | $8.39M | $5.95M | $2.06M |
| Other | -$181.65M | $0 | $113.74M | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Total Operating Expenses | $37.91M | $208.57M | $243.19M | $87.11M | $84.39M | $79.86M | $79.43M | $49.35M | $32.88M | $26.53M | $17.4M | $8.88M |
| Operating Income (EBIT) | -$209.56M | -$208.57M | -$242.3M | -$84.78M | -$65.65M | -$81.48M | -$80.33M | -$45.46M | -$27.68M | -$21.91M | -$11.31M | -$8.9M |
| Operating Margin | - | - | -27348.0% | -3640.2% | -350.3% | - | - | -1169.3% | -531.7% | -473.3% | -185.9% | - |
| Interest Expense | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Interest Income | $24.89M | $21.31M | $6.15M | $837K | $111K | $593K | $2.14M | $1.17M | $482K | $244K | $22K | $1K |
| Other Income (Expense) | $54.34M | $599K | -$96.51M | $830K | -$11K | $588K | $2.08M | $1.11M | $440K | $208K | $20K | -$1.44M |
| Income Before Tax (EBT) | -$155.22M | -$207.97M | -$338.82M | -$83.95M | -$65.66M | -$80.89M | -$78.25M | -$44.35M | -$27.24M | -$21.7M | -$11.29M | -$10.35M |
| Income Tax Expense | -$15K | $51K | -$26K | -$136K | $141K | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Net Income | -$155.2M | -$208.02M | -$338.79M | -$83.81M | -$65.8M | -$80.89M | -$78.25M | -$44.35M | -$27.24M | -$21.7M | -$11.29M | -$10.35M |
| Net Income Margin | - | - | -38238.1% | -3598.8% | -351.1% | - | - | -1140.6% | -523.3% | -468.8% | -185.6% | - |
| Supplementary Data | ||||||||||||
| EPS | -1.98 | -3.18 | -46.15 | -24.86 | -25.02 | -37.89 | -61.23 | -53.25 | -45.01 | -55.40 | -24.71 | -18.91 |
| Diluted EPS | -1.98 | -3.18 | -46.15 | -24.86 | -25.02 | -37.89 | -61.23 | -53.25 | -45.01 | -55.40 | -24.71 | -18.91 |
| Weighted Average OS | 64.06M | 47.03M | 6.90M | 3.37M | 2.63M | 2.13M | 1.28M | 832,902 | 605,127 | 391,669 | 457,193 | 547,193 |
| EBITDA | -$209.56M | -$207.97M | -$127.82M | -$81.99M | -$64.08M | -$79.9M | -$77.35M | -$45.17M | -$27.43M | -$21.77M | -$11.23M | -$10.33M |
| EBITDA Margin | - | - | -14426.6% | -3520.3% | -342.0% | - | - | -1161.8% | -526.9% | -470.5% | -184.5% | - |
Balance Sheet
| Period | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 | FY 2015 | FY 2014 | FY 2013 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Currency | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD |
| Period Ending | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | 2020-12-31 | 2019-12-31 | 2018-12-31 | 2017-12-31 | 2016-12-31 | 2015-12-31 | 2014-12-31 | 2013-12-31 |
| Assets | |||||||||||||
| Current Assets | |||||||||||||
| Cash and Cash Equivalents | $85.72M | $89.42M | $188.89M | $34.86M | $15.14M | $90.09M | $19.25M | $22.46M | $12.82M | $47.75M | $29.29M | $2.62M | $4.6M |
| Short-Term Investments | $670.81M | $513.66M | $150.38M | $20.85M | $77.99M | $56.18M | $52.7M | $52.05M | $37.48M | $15.75M | $3.77M | $0 | $0 |
| Cash and Short-Term Investments | $756.53M | $603.09M | $339.28M | $55.71M | $93.13M | $146.27M | $71.95M | $74.51M | $50.3M | $63.5M | $33.06M | $2.62M | $4.6M |
| Accounts Receivable | $0 | $0 | $0 | $375K | $815K | $0 | $0 | $0 | $3.08M | $1.22M | $1.7M | $0 | $0 |
| Inventory | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Other Current Assets | $21.25M | $5.39M | $2.25M | $6.17M | $0 | $0 | $0 | $0 | $0 | $0 | $2.62M | $40K | $0 |
| Total Current Assets | $777.78M | $608.47M | $341.53M | $62.26M | $98.89M | $149.79M | $74.5M | $76.67M | $54.99M | $66.42M | $38.29M | $2.73M | $4.6M |
| Long-Term Assets | |||||||||||||
| Property, Plant & Equipment Net | $0 | $0 | $0 | $6.65M | $8.36M | $9.87M | $7.11M | $1.02M | $854K | $599K | $348K | $162K | $0 |
| Goodwill | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Intangible Assets | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Long-Term Investments | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Deferred Tax Assets | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Other Long-Term Assets | $0 | $10K | $331K | $2.24M | $2.68M | $1.96M | $1.57M | $50K | $232K | $40K | $20K | $38K | $0 |
| Total Long-Term Assets | $0 | $10K | $331K | $8.89M | $11.04M | $11.83M | $8.68M | $1.07M | $1.09M | $639K | $368K | $200K | $0 |
| Other Assets | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Total Assets | $777.78M | $608.48M | $341.86M | $71.14M | $109.93M | $161.62M | $83.18M | $77.74M | $56.08M | $67.06M | $38.65M | $2.93M | $4.6M |
| Liabilities | |||||||||||||
| Current Liabilities | |||||||||||||
| Accounts Payable | $8.9M | $666K | $896K | $677K | $3.32M | $2.25M | $3.15M | $663K | $389K | $168K | $176K | $345K | $217K |
| Short-Term Debt | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Current Income Tax Payable | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Current Unearned Revenue | $0 | $0 | $0 | $517K | $2.36M | $0 | $0 | $0 | $20K | $71K | $0 | $0 | $0 |
| Other Current Liabilities | $30.94M | $31.27M | $5.93M | $4.92M | $4.99M | $4.18M | $3.74M | $2.78M | $3.38M | $1.5M | $621K | $284K | $492K |
| Total Current Liabilities | $58.69M | $54.06M | $31.98M | $14.66M | $20.14M | $16.44M | $18.36M | $10.24M | $5.63M | $3.96M | $2.52M | $1.06M | $1.41M |
| Long-Term Liabilities | |||||||||||||
| Long-Term Debt | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Long-Term Unearned Revenue | $0 | $0 | $0 | $2.18M | $1.22M | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Long-Term Deferred Tax Liabilities | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Other Long-Term Liabilities | $3.86M | $36.62M | $125.86M | $0 | $0 | $214K | $31K | $72K | $111K | $132K | $27K | $0 | $0 |
| Total Long-Term Liabilities | $3.86M | $36.62M | $125.86M | $6.18M | $5.84M | $5.34M | $4.74M | $72K | $111K | $132K | $27K | $0 | $0 |
| Other Liabilities | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Total Liabilities | $62.55M | $90.68M | $157.84M | $20.84M | $25.98M | $21.79M | $23.1M | $10.31M | $5.74M | $4.1M | $2.55M | $1.06M | $1.41M |
| Stockholders' Equity | |||||||||||||
| Preferred Stock | $155.82M | $155.82M | $184.93M | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $58.31M | $13.35M | $4.46M |
| Common Stock | $15K | $13K | $10K | $6K | $5K | $5K | $3K | $2K | $2K | $1K | $0 | $811K | $664K |
| Retained Earnings | -$1.13B | -$972.43M | -$764.41M | -$425.62M | -$341.81M | -$276.01M | -$195.12M | -$116.86M | -$72.51M | -$45.28M | -$23.58M | -$12.28M | -$1.94M |
| Comprehensive Income & Other | $869K | $180K | $302K | -$48K | -$20K | $11K | $51K | -$27K | -$102K | -$4K | -$1K | $0 | $0 |
| Other Stockholders' Equity | $1.84B | $1.49B | $948.42M | $475.92M | $425.75M | $415.83M | $255.19M | $184.29M | $122.85M | $108.24M | $59.68M | $13.35M | $4.46M |
| Total Equity | $715.24M | $517.8M | $184.02M | $50.3M | $83.94M | $139.83M | $60.08M | $67.43M | $50.34M | $62.97M | $36.1M | $1.87M | $3.19M |
| Minority Interest | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Total Liabilities and Equity | $777.78M | $608.48M | $341.86M | $71.14M | $109.93M | $161.62M | $83.18M | $77.74M | $56.08M | $67.06M | $38.65M | $2.93M | $4.6M |
| Supplementary Data | |||||||||||||
| Total Debt | $0 | $0 | $0 | $4.63M | $5.06M | $5.45M | $5.06M | $0 | $0 | $0 | $0 | $0 | $0 |
| Net Debt | -$85.72M | -$89.42M | -$188.89M | -$30.23M | -$10.08M | -$84.65M | -$14.19M | -$22.46M | -$12.82M | -$47.75M | -$29.29M | -$2.62M | -$4.6M |
Cash Flow Statement
| Period | FY 2025 | FY 2024 | FY 2023 | FY 2022 | FY 2021 | FY 2020 | FY 2019 | FY 2018 | FY 2017 | FY 2016 | FY 2015 | FY 2014 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Currency | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD | USD |
| Period Ending | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | 2020-12-31 | 2019-12-31 | 2018-12-31 | 2017-12-31 | 2016-12-31 | 2015-12-31 | 2014-12-31 |
| Operating Activities | ||||||||||||
| Net Income | -$155.2M | -$208.02M | -$338.79M | -$83.81M | -$65.8M | -$80.89M | -$78.25M | -$44.35M | -$27.24M | -$21.7M | -$11.29M | -$10.35M |
| Depreciation & Amortization | $10M | $0 | $744K | $1.96M | $1.58M | $996K | $901K | $293K | $249K | $132K | $89K | $19K |
| Deferred Income Tax | $0 | $0 | $0 | -$327K | $0 | -$213K | $0 | $0 | $0 | $0 | $0 | $0 |
| Stock-Based Compensation | $37.61M | $44.83M | $25.68M | $7.11M | $8.04M | $6.26M | $0 | $0 | $0 | $0 | $767K | $147K |
| Changes in Working Capital: | ||||||||||||
| Accounts Receivable | $0 | $0 | $375K | $440K | -$815K | $0 | $0 | $3.08M | -$1.86M | $482K | -$1.7M | $0 |
| Inventory | $0 | $0 | $0 | -$440K | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Accounts Payable | $7.65M | -$230K | $218K | -$2.64M | $1.06M | -$544K | $2.58M | $239K | $164K | -$8K | -$169K | -$165K |
| Other Working Capital | -$13.58M | -$4.3M | -$5.8M | -$2.86M | $1.58M | -$2M | $4.52M | $3.88M | $1.5M | $976K | $533K | $191K |
| Total Working Capital Change | -$5.93M | -$4.53M | -$5.21M | -$5.5M | $1.83M | -$2.54M | $7.1M | $7.2M | -$198K | $1.45M | -$1.33M | $26K |
| Other Non-Cash Items | -$55.73M | $10.31M | $217.67M | $426K | $638K | $619K | $3.78M | $1.93M | $4.77M | $1.07M | $790K | $2.82M |
| Net Cash from Operating | -$169.25M | -$157.41M | -$99.91M | -$80.14M | -$53.72M | -$75.78M | -$65.69M | -$32.19M | -$24.61M | -$18.84M | -$10.98M | -$7.33M |
| Investing Activities | ||||||||||||
| Capital Expenditures | $0 | $0 | $0 | -$38K | -$573K | -$4.28M | -$1.49M | -$422K | -$619K | -$212K | -$208K | -$181K |
| Acquisitions | $0 | $0 | $3.04M | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Purchases of Investments | -$522.21M | -$599.25M | -$166.8M | -$39.5M | -$133.08M | -$129M | -$91.93M | -$62.18M | -$64.11M | -$20.39M | -$3.77M | $0 |
| Sales of Investments | $371.74M | $245.97M | $39.9M | $96.55M | $111.03M | $125.68M | $91.68M | $47.37M | $42.2M | $8.45M | $0 | $0 |
| Other Investing Activities | $7M | $0 | $15.47M | $0 | $0 | $0 | $0 | $0 | $0 | $0 | -$40K | -$40K |
| Net Cash from Investing | -$143.47M | -$353.29M | -$108.39M | $57.01M | -$22.62M | -$7.6M | -$1.74M | -$15.23M | -$22.53M | -$12.16M | -$4.01M | -$221K |
| Financing Activities | ||||||||||||
| Debt Repaid | - | - | $16K | $418K | $510K | $20K | $25K | - | - | - | - | - |
| Common Stock Issuance | $314.44M | $236.38M | $169.11M | $42.87M | $0 | $153.72M | $64.3M | $54.05M | $11.38M | $49.29M | $43.68M | $5.58M |
| Common Stock Repurchases | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | -$2.03M | $0 |
| Dividends Paid | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Other Financing Activities | -$5.41M | $5.67M | -$5.38M | $222K | $1.9M | $816K | $1.45M | $3.02M | $833K | $76K | $23K | $0 |
| Net Cash from Financing | $309.02M | $410.91M | $361.08M | $42.68M | $1.39M | $154.51M | $65.72M | $57.07M | $12.21M | $49.37M | $41.67M | $5.58M |
| Forex Effect | $0 | -$3K | $25K | -$106K | -$15K | $51K | -$1.5M | $0 | $0 | $0 | $0 | $0 |
| Net Change in Cash | -$3.7M | -$99.79M | $152.8M | $19.44M | -$74.96M | $71.18M | -$3.21M | $9.64M | -$34.93M | $18.37M | $26.68M | -$1.98M |
| Supplementary Data | ||||||||||||
| Operating Cash Flow | -$169.25M | -$157.41M | -$99.91M | -$80.14M | -$53.72M | -$75.78M | -$65.69M | -$32.19M | -$24.61M | -$18.84M | -$10.98M | -$7.33M |
| Capital Expenditure | $0 | $0 | $0 | -$38K | -$573K | -$4.28M | -$1.49M | -$422K | -$619K | -$212K | -$208K | -$181K |
| Free Cash Flow | -$169.25M | -$157.41M | -$99.91M | -$80.18M | -$54.29M | -$80.06M | -$67.18M | -$32.62M | -$25.23M | -$19.05M | -$11.19M | -$7.52M |
| Cash at Beginning | $89.42M | $189.22M | $36.42M | $16.98M | $91.94M | $20.75M | $22.46M | $12.82M | $47.75M | $29.37M | $2.62M | $4.6M |
| Cash at End | $85.72M | $89.42M | $189.22M | $36.42M | $16.98M | $91.94M | $19.25M | $22.46M | $12.82M | $47.75M | $29.29M | $2.62M |