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Upstream Bio, Inc. (UPB)

Upstream Bio, Inc. (UPB) Insider Trading

Directors, officers and holders of more than 10% of UPB report their trades in its stock on SEC Form 4, within two business days. Each row below is one Form 4 transaction line. The one-letter code says what kind of transaction it was: only P (purchase) and S (sale) are open-market or private trades; awards, option exercises, tax withholding and gifts carry other codes.

Recent Form 4 transactions

The 50 most recent of 72 transactions on file: 2 with code P, 15 with code S and 33 with other codes.

DateInsiderCodeShares
Sep 16, 2026Houghton AdamS Sale700
Sep 16, 2026Sutherland Everett RandS Sale2,095
Sep 16, 2026Deykin AaronS Sale895
Sep 16, 2026Ambrose AllisonS Sale485
Sep 16, 2026GRAY MICHAELS Sale853
Jun 16, 2026GRAY MICHAELS Sale853
Jun 16, 2026Sutherland Everett RandS Sale2,095
Jun 16, 2026Houghton AdamS Sale700
Jun 16, 2026Deykin AaronS Sale895
Jun 16, 2026Ambrose AllisonS Sale477
Jun 9, 2026Ratcliffe LiamA Award17,096
Jun 9, 2026Beckman DaniellaA Award17,096
Jun 9, 2026Fleming Harold EdwardA Award17,096
Jun 9, 2026Renaud Ronald C JRA Award17,096
Jun 9, 2026Ruddy Marcella K.A Award17,096
Jun 9, 2026Chimovits ErezA Award17,096
Mar 16, 2026Houghton AdamS Sale699
Mar 16, 2026GRAY MICHAELS Sale852
Mar 16, 2026Deykin AaronS Sale894
Mar 16, 2026Sutherland Everett RandS Sale2,093
Mar 16, 2026Ambrose AllisonS Sale475
Jan 2, 2026GRAY MICHAELA Award30,500
Jan 2, 2026Deykin AaronA Award32,000
Jan 2, 2026Ambrose AllisonA Award17,000
Jan 2, 2026Houghton AdamA Award25,000
Jan 2, 2026Sutherland Everett RandA Award75,000
Jan 2, 2026GRAY MICHAELA Award91,500
Jan 2, 2026Deykin AaronA Award96,000
Jan 2, 2026Ambrose AllisonA Award51,000
Jan 2, 2026Houghton AdamA Award75,000
Jan 2, 2026Sutherland Everett RandA Award225,000
Jun 10, 2025Ratcliffe LiamA Award17,096
Jun 10, 2025Ruddy Marcella K.A Award17,096
Jun 10, 2025Beckman DaniellaA Award17,096
Jun 10, 2025Renaud Ronald C JRA Award17,096
Jun 10, 2025Chimovits ErezA Award17,096
Jun 10, 2025Fleming Harold EdwardA Award17,096
Feb 6, 2025Sutherland Everett RandA Award500,000
Feb 6, 2025Ambrose AllisonA Award25,000
Feb 6, 2025Deykin AaronA Award165,000
Feb 6, 2025Houghton AdamA Award140,000
Feb 6, 2025GRAY MICHAELA Award195,000
Dec 16, 2024Ambrose AllisonA Award100,000
Oct 15, 2024ORBIMED ADVISORS LLCC Conversion789,833
Oct 15, 2024Wellington Biomedical Innovation Master Investors (Cayman) II L.P.C Conversion852,940
Oct 15, 2024Wellington Biomedical Innovation Master Investors (Cayman) II L.P.C Conversion894,733
Oct 15, 2024AI Upstream LLCC Conversion1,172,410
Oct 15, 2024AI Upstream LLCC Conversion3,147,000
Oct 15, 2024AI Upstream LLCP Purchase1,175,000
Oct 15, 2024ORBIMED ADVISORS LLCP Purchase660,000

The full Form 4 history is on the UPB company page (Insider Trades card, View all).

Questions about this data

Which insider transactions are open-market trades?

Code P (open market or private purchase) and code S (open market or private sale). Code F is shares withheld to pay tax on vesting stock, A is an award from the company, M and X are option exercises and G is a gift. None of those is the insider choosing to buy or sell in the market.

How quickly are insider trades reported?

A Form 4 is due before the end of the second business day after the trade. The date shown is the transaction date from the form.

Who has to file Form 4?

Officers, directors and beneficial owners of more than 10% of a class of the company’s registered equity, under Section 16 of the Securities Exchange Act.

Look up any code in the Form 4 transaction code reference, or read Form 4 codes explained.